Clinical and Experimental Surgery

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1 Eur Surg Res 50(2) (2013) print ISSN X online e-issn Clinical and Experimental Surgery S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. New Delhi. Bangkok. Beijing. Tokyo. Kuala Lumpur. Singapore. Sydney

2 Transforming Vesalius The medical revolution of the 16th century brought to life for the 21st century AnDREAS V ESAliUS The Fabric of the Human Body An Annotated Translation of the 1543 and 1555 Editions of De Humani Corporis Fabrica by D A nie l H. GARRi S o n M A l C olm H. HAST Modern layout enables the 21st-century reader to understand the complexity and pioneering nature of this milestone in medical history without the need of knowing Latin Vesalius, A. The Fabric of the Human Body An Annotated Translation of the 1543 and 1555 Editions of De Humani Corporis Fabrica, by D. H. Garrison and M. H. Hast Approx. 1,400 pages in two books Hard cover with slip case / mm Approx. 30 lbs / 14 kg List price: CHF 1,500. / EUR 1,250. / USD 1, Pre-publication price: CHF 1,125. / EUR 935. / USD 1, Valid until end of September 2013 Postage and handling included VAT & import taxes excluded EUR price for Germany, USD price for USA only ISBN Different colors allow easy identification of notes relevant to both the 1543 and the 1555 editions Added notes for a never published third edition Up-to-date design and high-resolution digital scans of the woodcuts Nomina Anatomica and Terminologia Anatomica for the first time included to provide Vesalius descriptions with modern medical terminology Prefaces by the translators and introductions by medical historians Vivian Nutton and Nancy Siraisi Special pre-publication offer until September KI 13215

3 Clinical and Experimental Surgery Founded 1969 Editors: W. Brendel ( ) and K. Messmer ( ); O. Kempski ( ) European Society for Surgical Research (ESSR) ESSR Representative M. Cikirikcioglu, Geneva Editor-in-Chief B. Vollmar, Rostock Associate Editors M. Boros, Szeged M. Büchler, Heidelberg W.P. Ceelen, Ghent M.D. Menger, Homburg/Saar H. Thorlacius, Malmö/Lund Editorial Board I. Alwayn, Halifax D.K. Bartsch, Marburg C. Bassi, Verona W.O. Bechstein, Frankfurt am Main J.A. Bradley, Cambridge M. Cikirikcioglu, Geneva P.-A. Clavien, Zurich C. Eipel, Rostock R.W.F. de Bruin, Rotterdam H. Friess, Munich S. Fichtner-Feigl, Regensburg G. Galata, London D.J. Gouma, Amsterdam J.K. Habermann, Lübeck M. Heberer, Basel T. Hubert, Lille W.R. Jarnagin, New York, NY J.C. Kalff, Bonn M.W. Laschke, Homburg/Saar H.-A. Lehr, Lausanne C.M. Malata, Cambridge T. Minor, Bonn M. Morino, Torino J. Pirenne, Leuven R. Schramm, Munich L. Steinstraesser, Bochum T.M. van Gulik, Amsterdam M.A. Venermo, Helsinki D.C. Winter, Dublin Y. Yamamoto, Akita Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel Appears 6-weekly: 2 volumes per year (8 issues)

4 Guidelines for Authors Aims and Scope The prime mission of European Surgical Research is to publish high-quality original manuscripts of basic and translational research and review articles concerned with laboratory and clinical investigations which are relevant to surgical practice and of general interest to a broad range of academic surgeons and surgical researchers. Manuscripts dealing with research relevance to human surgical diseases are given high priority along with those which explore the pathogenesis, etiology, and mechanisms of disease processes. European Surgical Research seeks to preferentially publish research articles that integrate molecular biological methods, along with functional studies, into the analysis of biological questions and that advance basic and translational knowledge of surgical pathophysiology. European Surgical Research will provide an international platform for basic and translational research and clinical investigations impacting directly on surgical care and management. European Surgical Research also features special articles relating to educational, research, or social issues of interest to the academic surgical community. Submission Only original papers written in English are considered and should be submitted online: All manuscripts must be accompanied by a cover letter and copyright signed by all authors. Assurance should be given in the cover letter that the manuscript is not under simultaneous consideration by any other publication. Authors may suggest up to five referees who have expert knowledge on the subject. Suggested referees should not be from the same institution, not have published with the authors during the last 5 years, and should not be prejudiced. Manuscripts may be submitted to the following sections: (1) Original Papers on basic, translational and clinical science (2) Technical Notes (3) Reviews Original Papers: These manuscripts should represent original research in basic, translational, or clinical science. Consideration for publication is based on originality, novelty, scientific soundness, and appropriate analysis. European Surgical Research encourages the submission of relevant and well-conducted work in basic, experimental, and clinical science. Manuscripts should be prepared according to the guidelines for original papers. Technical Notes: These manuscripts present a new method, experimental model, test procedure, tool, or algorithm that is relevant for surgical research and significantly advances current available knowledge. Reviews in which a specific field is reviewed through an exhaustive literature survey. An Abstract is required and should be divided into Background, Summary and Key Messages. Review Articles should consist of a maximum of 4,000 words. European Surgical Research aims to publish expert basic and translational reviews of selected up-to-date topics in experimental surgery. On occasion, the Editor-in-Chief will invite additional clinical or basic science reviews on a specific topic, which are usually presented pair-wise. Exceptions include formal true Systematic Reviews with Meta-Analyses which are well performed, and which are considered Original Papers. Should you experience any problems with your submission, please contact: esr@karger.ch Editorial Office European Surgical Research S. Karger AG Angela Lorenz PO Box CH 4009 Basel (Switzerland) Tel Fax Conditions All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of European Surgical Research and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. Disclosure Statement Authors are required to disclose any sponsorship or funding arrangements relating to their research and all authors should disclose any possible conflicts of interest. Disclosure statements will be published at the end of the text of the article. Plagiarism Policy Whether intentional or not, plagiarism is a serious violation. We define plagiarism as a case in which a paper reproduces another work with at least 25% similarity and without citation. If evidence of plagiarism is found before/after acceptance or after publication of the paper, the author will be offered a chance for rebuttal. If the arguments are not found to be satisfactory, the manuscript will be retracted and the author sanctioned from publishing papers for a period to be determined by the responsible Editor. Ethics Published research must comply with the guidelines for human studies and animal welfare regulations. Authors should state that subjects have given their informed consent and that the study protocol has been approved by the institute s committee on human research. Further, they should also state that animal experiments conform to institutional standards. Authors are required to declare the approval codes obtained from the corresponding ethical committee on human and/or animal research. Arrangement The manuscript should conform to the following order: title page, abstract and key words, body, acknowledgments, references, figure legends, tables and figures. Manuscripts should be written in high-quality English suitable for effective communication to a professional medical audience. Authors who are not native speakers of English sometimes receive negative comments from referees or editors about the English-language usage in their manuscripts, and these problems can contribute to the decision to reject a paper. To help reduce the possibility of such problems, we strongly encourage such authors (i) to have their manuscript reviewed for clarity by a colleague whose native language is English and/or (ii) to use one of the many English language editing services that are available via the Web. All pages, including the figure legends, should be numbered in sequence, and the first author s name should appear at the upper right corner of each page. Papers not conforming to the journal style will be returned without review. Title page: The first page of each paper should indicate a concise title of no more than 150 characters, all authors names (first name and surname), authors institutional affiliations, and a short title for use as running head. Corresponding author: The exact postal address of author(s) to whom correspondence, proofs, and reprint requests should be sent, including the postal code, must be given at the bottom of the title page. Please also supply phone and number and address. Abstract of Reviews: Should be divided into the following subsections: Background, Summary and Key Messages. The Background should provide a brief clinical context for the review and is followed by the Summary, which should include a concise description of the main topics covered in the text. The Key Messages encapsulate the main conclusions of the review. Abstract of Original Papers and Technical Notes: Submit the abstract on a separate page. The abstract is structured into Background/Purpose, Methods, Results and Conclusions and should be less than 400 words in length. Key words: Following the abstract, an alphabetical list of five key words that reflect the content of the paper should be given. Footnotes: Avoid footnotes. Body of manuscript: The text should be organized into: Introduction, Materials and Methods, Results, Discussion, Acknowledgments, including grant numbers and sources of support, Disclosure/Duality of Interest (optional), and References. Abbreviations/acronyms are defined in both the abstract and body of the text as follows: vascular permeability factor (VPF); transforming growth factorb (TGF-b). They should only be used in the abstract if they appear twice after first being mentioned and in the body of the text only if they appear three times after first being mentioned. Tables and illustrations: Tables and illustrations (both numbered in sequential Arabic numerals) should be prepared as separate files. Tables require a brief and concise heading. Figures require a legend, prepared as a separate page, after references. Please use scale markers for electron micrographs, and indicate the type of stain used. For the reproduction of illustrations, only good drawings and original photographs can be accepted; negatives or photocopies cannot be used. Due to technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size mm) or provide crop marks. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800 1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 800. per page. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which karger@karger.com S. Karger AG, Basel The Guidelines for Authors are available at:

5 Guidelines for Authors they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals ( Examples (a) Papers published in periodicals: Chatel J-M, Bernard H, Orson FM: Isolation and characterization of two complete Ara h 2 isoforms cdna. Int Arch Allergy Immunol 2003;131: (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: / (c) Monographs: Matthews DE, Fare-well VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, (d) Edited books: DuBois RN: Cyclooxygenase-2 and colorectal cancer; in Dannenberg AJ, Dubois RN (eds): COX-2. Prog Exp Tum Res. Basel, Karger, 2003, vol 37, pp Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists. Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at Supplementary Material Supplementary material is restricted to additional data that are not necessary for the scientific integrity and conclusions of the paper. Please note that all supplementary files will undergo editorial review and should be submitted together with the original manuscript. The Editors reserve the right to limit the scope and length of the supplementary material. Supplementary material must meet production quality standards for Web publication without the need for any modification or editing. In general, supplementary files should not exceed 10 Mb in size. All figures and tables should have titles and legends and all files should be supplied separately and named clearly. Acceptable files and formats are: Word or PDF files, Excel spreadsheets (only if the data cannot be converted properly to a PDF file), and video files (.mov,.avi,.mpeg). Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at www. karger.com. The option is available for a one-time fee of CHF 3,000., which is a permissible cost in grant allocation. More information can be found at com/authors_choice. NIH-Funded Research The U.S. National Institutes of Health (NIH) mandates under the NIH Public Access Policy that final, peer-reviewed manuscripts appear in its digital database within 12 months of the official publication date. As a service to authors, Karger submits your manuscript on your behalf to PubMed Central (PMC) immediately upon publication. It usually receives a PMCID within approximately a month and will appear in PMC after 12 months. For those selecting our premium Author s Choice TM service, the usual embargo will be overridden, accelerating the accessibility of your work. Self-Archiving Karger permits authors to archive their pre-prints (i.e. pre-refereeing) or post-prints (i.e. final draft post-refereeing) on their personal or institution s servers, provided the following conditions are met: Articles may not be used for commercial purposes, must be linked to the publisher s version, and must acknowledge the publisher s copyright. Authors selecting Karger s Author s Choice TM feature, however, are also permitted to archive the final, published version of their article, which includes copyediting and design improvements as well as citation links. Page Charges A charge of CHF 125. per page will be levied for the first 4 printed pages of an article. Any additional page will be charged to the author at CHF The allotted size of a paper is equal to approx. 12 manuscript pages (including tables, illustrations and references). Proofs Unless indicated otherwise, proofs are sent to the corresponding author and should be returned with the least possible delay. Alterations other than the correction of printer s errors are charged to the author. Reprints Order forms and a price list are sent with the proofs. Orders submitted after the issue is printed are subject to considerably higher prices. For further information or a free online sample copy, log on to surgery Karg er Jour nals in... Surgery Surgery KI13632

6 General Information ISSN Print Edition: X ISSN Online Edition: Journal Homepage: Publication Data: European Surgical Research is published 8 times a year. Volumes 50 and 51, each with 4 issues, appear in Copyright: 2013 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF 784. CHF 880. EUR 632. EUR 710. USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF 72. Europe, CHF 104. Overseas EUR 56. USD Airmail surcharge: CHF 70. / USD Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.om. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Photocopying: This journal has been registered with the Copyright Clearance Center (CCC), as indicated by the code appearing on the first page of each article. For readers in the US, this code signals consent for copying of articles for personal or internal use, or for the personal or internal use of specific clients, provided that the stated fee is paid per copy directly to Copyright Clearance Center Inc. 222 Rosewood Drive Danvers, MA (USA) A copy of the first page of the article must accompany payment. Consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale. In these cases, specific written permission must be obtained from the copyright owner, S. Karger AG, P.O. Box CH 4009 Basel (Switzerland). Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) Change of Address: Both old and new address should be sent to the subscription source. or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: karger@snet.net France Librairie Médi-Sciences Sarl 36, bd de Latour-Maubourg Paris France t: +33 (0) f: +33 (0) e: librairie@medi-sciences.fr w: South East Asia, China and Taiwan Karger Regional Office (Malaysia) CEO Suite Kuala Lumpur Quill 7, 27th Floor Jalan Stesen Sentral 5 KL Sentral Kuala Lumpur Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 10th Floor, Twin Towers (East) B12 Jianguomenwai Avenue Beijing China t: f: e: service@karger.cn; r.chew@karger.cn w: India, Bangladesh, Sri Lanka Medscience India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: medsci.india@gmail.com karger@karger.com S. Karger AG, Basel The Guidelines for Authors are available at:

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

8 Be at the forefront of the latest developments in experimental surgery Clinical and Experimental Surgery Clinical and Experimental Surgery Editor-in-Chief B. Vollmar, Rostock Official Journal of the European Society for Surgical Research (ESSR) More information at Pay-per-View and Subscriber Access to Full Text Full Table of Contents Full Editorial Board Free Abstracts and Selected Articles Online Sample Issue Submission/Guidelines for Authors Subscription Details Free Alert Service Online Library Recommendation European Surgical Research 2013: Volumes 50, 51 4 issues per volume Language: English ISSN X ISSN online Listed in bibliographic services, including Current Contents, MEDLINE, Biological Abstracts, EMBASE/Excerpta Medica KF13035 Selected contributions Feasibility of Delayed Hyperthermic Intraperitoneal Chemotherapy in Case of Unforeseen Complications: Mohr, Z.; Hirche, C.; Liebeskind, U.; Rau, B.; Hünerbein, M. (Berlin) Intraperitoneal Administration of Bevacizumab Intraoperatively Does Not Affect Abdominal Wound Healing in Rats: Pavlidis, E.T.; Ballas, K.D.; Psarras, K.; Symeonidis, N.G.; Koliakos, G.; Kouzi-Koliakos, K.; Rafailidis, S.F.; Pavlidis, T.E.; Marakis, G.N.; Sakantamis, A.K. (Thessaloniki) Surgeon-Performed Ultrasound as Preoperative Localization Study in Patients with Primary Hyperparathyroidism: van Ginhoven, T.M. (Delft/Rotterdam); Morks, A.N. (Delft/Groningen); Schepers, T. (Delft/Rotterdam); de Graaf, P.W.; Smit, P.C. (Delft) Choosing the Best Animal Species to Mimic Clinical Colon Anastomotic Leakage in Humans: A Qualitative Systematic Review: Pommergaard, H.C.; Rosenberg, J. (Herlev); Schumacher-Petersen, C. (Copenhagen); Achiam, M.P. (Herlev) Biocompatibility of PLGA/sP(EO-stat-PO)-Coated Mesh Surfaces under Constant Shearing Stress: Böhm, G.; Ushakova, Y.; Alizai, H.P.; Braunschweig, T.; Lente, C. (Aachen); Heffels, K.-H.; Groll, J. (Würzburg); Neumann, U.P.; Junge, K. (Aachen) Comparative Study of Surgical Margins and Cosmetic Outcome in Lumpectomy versus Segmental Resection in Breast Cancer: Eggemann, H.; Ignatov, A. (Magdeburg); Krocker, J.; Neuss, K.; Elling, D. (Berlin); John, J.; Costa, S.-D. (Magdeburg) Bioabsorbable Staple-Line Reinforcement for Pancreatectomy in a Porcine Model: A Preliminary Study: Hornez, E. (Marseille/Toulon); Garnier, E.; Sastre, B.; Garcia, S. (Marseille); Mayet, A. (Saint Mande); Berdah, S.V. (Marseille) Substance P and Neprilysin in Chronic Pancreatitis : Mascetta, G. (San Giovanni Rotondo/Verona); di Mola, F.F.; Tavano, F. (San Giovanni Rotondo); Selvaggi, F.; Giese, N. (Heidelberg); Bassi, C. (Verona); Büchler, M.W. (Heidelberg); Friess, H. (Munich); di Sebastiano, P. (San Giovanni Rotondo/Verona/Heidelberg) JOURNAL European Surgical Research features original clinical and experimental papers, condensed reviews of new knowledge relevant to surgical research, and short technical notes serving the information needs of investigators in various fields of operative medicine. Coverage includes surgery, surgical pathophysiology, drug usage, and new surgical techniques. Special consideration is given to information on the use of animal models, physiological and biological methods as well as biophysical measuring and recording systems. The journal is of particular value for workers interested in pathophysiologic concepts, new techniques and in how these can be introduced into clinical work or applied when critical decisions are made concerning the use of new procedures or drugs.

9 Review 57 Experimental Models of Hemorrhagic Shock: A Review Fülöp, A.; Turóczi, Z.; Garbaisz, D.; Harsányi, L.; Szijártó, A. (Budapest) Original Paper 71 Distal Pancreatectomy Utilizing a Flexible Stapler Closure Eliminates the Risk of Pancreas-Related Factors for Postoperative Pancreatic Fistula Kawabata, Y.; Nishi, T.; Tanaka, T.; Yano, S.; Tajima, Y. (Izumo) Abstracts 80 The 2012 ESSR Congress June 6 9, 2012, Lille, France Guest Editor: Hubert, T. (Lille) 252 ESSR News

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