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1 by i-optics Premium treatment starts with premium diagnosis Complete your cataract-refractive platform

2 The premium IOL opportunity Premium IOL market to nearly double in next 5 years million 22 million There is a huge global unmet need for improved vision correction during cataract surgery. With the total volume of cataract surgeries rising to approximately 30 million per year in 2030, more than 50% of these patients could benefit from astigmatism correction. The challenge of determining the exact axis of astigmatism for cataract surgery Cassini million million 87,5% increase A. John Kanellopoulos, MD. Clinical Professor Of Ophthalmology New York University Medical School 0 Number of patients Cataract surgery volume globally Volume of premium IOL s implanted globally Source: Market scope 2013 Comprehensive Report on the Global IOL Market The expectations and demands of patients have risen in recent years and the search for perfection becomes critical, especially when it comes to astigmatism correction.

3 Getting the Axis right Axis repeatability in complicated corneas What top surgeons have to say about Cassini 10 Cassini is a better alternative for toric IOL planning and, as such, stands to pave the way for surgeons who have been hesitant to implant these premium lenses Steep Axis repeatability in degrees Douglas Koch, M.D. Baylor College of Medicine, Houston, TX, USA Superior in central corneal measurement to Placido and Scheimpflug in case of high irregularity A. John Kanellopoulos, M.D. Laservision Eye Institute, Athens, Greece New York University Medical School, New York, USA 0 Post-LASIK (n=51) Keratoconus (n=95) Pre-cataract corneas<1.00d (n=75) With Cassini preoperative planning, you can confidently treat your patient s cataract with Toric IOLs and provide precise astigmatism correction in a single procedure Jonathan Solomon, M.D. Solomon Eye Associates, Bowie, MD, USA Source: Kanellopoulos, Asimellis, Friess. CRSToday 2014

4 Total Corneal Astigmatism Cassini uses patented multi-colored LED point-to-point ray tracing to provide a GPS-like analysis of the cornea along with high-resolution images utilized for surgical guidance. The unique measuring principle enables highly accurate and repeatable measurements of the Total Corneal Astigmatism. Multi-colored LED point-to-point ray tracing 2 nd Purkinje point-to-point ray tracing technology Cassini provides critical information to properly select the power and position of Toric intraocular lenses

5 True Technology True Central Coverage - No Central Scotoma True Axis - True Magnitude Cassini mm 5 mm 7 mm A. John Kanellopoulos, MD. Clinical Professor Of Ophthalmology New York University Medical School The multi-colored LED coverage is equal across the entire cornea, leaving no space for central scotoma. The accurate axis and magnitude of astigmatism plays a vital part in the correct selection and positioning of a toric IOL.

6 Increase your Confidence Addressing the four most common problems when correcting astigmatism* Post-op measurement Pre-op measurements The accurate post-op Cassini measurements enable the surgeon to optimize the Surgically Induced Astigmatism (SIA) With it s accuracy and precision, Cassini reduces pre-operative measurements errors Correct toric alignment Accurate marking Based on highly accurate measurements and marking, the Toric alignment can be done with high level of confidence Along with real time eye-tracking systems such as TrueGuide **, Cassini can eliminate marking errors * Berdahl JP, Chu YR, Hill WE. EyeNet, April 2012 Toric IOLs: Four Options for Addressing Residual Astigmatism. **TrueGuide is a trademark of TrueVision 3D Surgical, Inc

7 Drive more Toric procedures More than 50% of patients eligible for astigmatic correction 8.7% Commonly corrected Not ideal for astigmatism correction 47.4% Your opportunity to expand Most people have astigmatism to some extent. A study of more than 6,000 cataract patients confirms that over 50% of cataract patients have a level of astigmatism that falls within the range correctable by a Toric IOL. That means that a premium IOL is an excellent option for a significant number of your cataract patients. 19.1% Percentage of patients 11.2% 17.1% 14.8% 12.0% 7.8% 43.8% Your opportunity to expand True data increases your confidence in expanding your premium procedure volume. 5.5% 3.7% 2.9% 1.4% 2.2% 1.3% 0.9% < > 3.00 Dioptric intervals in D Source: Hill Distribution Data. Provided courtesy of Dr. Warren Hill.

8 Update by i-optics Cassini Specifications True Axis True Magnitude Multicolor LED Ray-Tracing combined with 2nd Purkinje Imaging Technology Axis repeatability within 3 degrees Diopter range 4.00D D Display K-values per zone 3 / 5 / 7 / 9 mm True Capture True Accuracy Instantaneous Auto Capturing Measurement Quality Factor parameter Topographic indices: Shape factor, eccentricity, Asphericity, form factor Keratoconus indices: Surface Asymmetry Index, Surface Regularity Index Submicron accuracy due to color LED triangulation technology <0.8µm 528 mm/20.8 True Technology Pupillometry programs - mesopic & photopic HD External Ocular Photography Topographic maps: Axial, Refractive, Tangential, Elevation, Recorded Image and High Order Aberrations Multiple color scale options Incorporated Patient management program Connectivity: Femto secondlasers, Guidance systems, Toric IOL calculators, USB, Direct print, PDF, JPG, PNG, Excel For more information: i-optics USA - usa@i-optics.com i-optics International - info@i-optics.com Distributed by: IQ Medical Pty Ltd 2/86 Mary Street, Unley SA 5061 Phone (08) sales@iqmedical.com.au Web mm/ mm/12.3 CA.BR.INT.4.15

* Villegas EL, Alcón E, Artal P. Minimum amount of astigmatism that should be corrected. J Cataract Refract Surg 2014; 40: n My SIA: Ø Centroid

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