Cerebrovasc Dis 40(3 4) 101 200 (2015) 40 3 4 15 print ISSN 1015 9770 online e-issn 1421 9786 www.karger.com/ced Official journal of the Highlights in this issue: european stroke conference Evolution from Stroke Risk Factors to Brain Health Determinants. 11th Johann Jacob Wepfer Lecture, European Stroke Conference, Vienna, Austria 2015 Sacco, R.L. Phenotypic ASCO Characterisation of Young Patients with Ischemic Stroke in the Prospective Multicentre Observational sifap1 Study Wolf, M.E.; Grittner, U.; Böttcher, T.; Norrving, B.; Rolfs, A.; Hennerici, M.G.; on behalf of the sifap1 TM investigators Collateral Circulation Predicts the Size of the Infarct Core and the Proportion of Salvageable Penumbra in Hyperacute Ischemic Stroke Patients Treated with Intravenous Thrombolysis Rusanen, H.; Saarinen, J.T.; Sillanpää, N. S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney
Karger Publishers 125 Years of Experience in Medical and Festschrift Karger Connecting the World of Biomedical Science This richly illustrated Festschrift chronicles the company s development and contributions in the service of medicine and science since 1890. It tells the history of Karger Publishers until the present day. Medical and Scientific Publishers Please send an e-mail to 125years@karger.com to receive your free copy or discover it online. www.karger.com/festschrift Publishing Highlights 1890 2015 Take a guided tour through 125 years of medical and scientific publishing! Follow us on a leisurely walk through interesting times, fascinating topics and beautiful illustrations. www.karger.com/highlights Karger Gazette The Karger Gazette anniversary issue explores the STM publishing business in the digital age, offers short portraits of Karger s journal and book series editors as well as interviews with three renowned scientists. www.karger.com/gazette KI15184
Founded 1991 by J. Bogousslavsky and M.G. Hennerici An Official Journal of european stroke conference Affiliated with European Stroke Conference European Society of Neurosonology and Cerebral Hemodynamics ASIA Pacific Stroke Organisation Editor-in-Chief Michael G. Hennerici University Medicine Mannheim, Mannheim, Germany Associate Editors Harold P. Adams Jr. University of Iowa Carver College of Medicine, Iowa City, USA Craig Anderson The George Institute for Global Health, Camperdown, Australia Dale Corbett University of Ottawa, Ottawa, Canada Larry B. Goldstein University of Kentucky, Lexington, USA Lorenz Hirt Lausanne University Hospital, Lausanne, Switzerland Jong-Sung Kim University of Ulsan College of Medicine, Seoul, Republic of Korea Yoshihiro Kokubo National Cerebral and Cardiovascular Center Suita, Osaka, Japan Stephen Meairs University Medicine Mannheim, Mannheim, Germany Man Mohan Mehndiratta Janakpuri Super Speciality Hospital, New Delhi, India Jay P. Mohr Neurological Institute, Tananbaum Stroke Center, New York, USA Yukito Shinohara Tachikawa Hospital, Tokyo, Japan Narayanaswamy Venketasubramanian Raffles Neuroscience Centre, Singapore, Singapore Managing Editor Marc Fatar University Medicine Mannheim, Mannheim, Germany Editorial Board Robert H. Ackerman Massachusetts General Hospital, Boston, USA Juan F. Arenillas University of Valladolid, Valladolid, Spain Georg W.J. Auburger Goethe University Hospital, Frankfurt am Main, Germany Hakan Ay Massachusetts General Hospital, Charlestown, USA Jean-Claude Baron Sainte-Anne Hospital, Sorbonne, Paris, France Julien Bogousslavsky Genolier Swiss Medical Network, Montreux, Switzerland Natan Bornstein Tel Aviv Medical Center, Tel Aviv, Israel Louis R. Caplan Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA Hugues Chabriat Lariboisiere Hospital, Paris, France Anastasios Chatzikonstantinou University Medicine Mannheim, Mannheim, Germany Leonardo G. Cohen National Institute of Neurological Disorders and Stroke, Bethesda, USA Stephen M. Davis Royal Melbourne Hospital, Parkville, Australia Gabriel R. de Freitas Institute D Or, Rio de Janeiro, Brazil Moise Desvarieux Columbia University, New York, USA Hans-Christoph Diener University Duisburg-Essen, Essen, Germany Ulrich Dirnagl Humboldt University, Berlin, Germany Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim
Nima Etminan Heinrich-Heine-University, Düsseldorf, Germany Klaus Fassbender University Clinic, Homburg/Saar, Germany Franz Fazekas Medical University Graz, Graz, Austria Valery L. Feigin Auckland University of Technology, Auckland, New Zealand José M. Ferro University of Lisboa, Hospital de Santa Maria, Lisbon, Portugal Jochen B. Fiebach Charité University Medicine, Berlin, Germany Nancy Futrell Intermountain Stroke Center, Salt Lake City, USA Achim Gass University Medicine Mannheim, Mannheim, Germany Steven M. Greenberg Massachusetts General Hospital, Boston, USA Roman Haberl Medical Clinic Harlaching, München, Germany Graeme J. Hankey Royal Perth Hospital, Perth, Australia Wolf-Dieter Heiss Max-Planck-Institute, Köln, Germany Marc Hommel University Hospital Grenoble, Grenoble, France Frances Horgan Royal College of Surgeons in Ireland, Dublin, Ireland Constantino Iadecola Weill Cornell Medical College, New York, USA Jaap L.J. Kappelle University Medical Center, Utrecht, Netherlands Carlos S. Kase Boston University School of Medicine, Boston, USA Christof Kessler Ernst-Moritz-Arndt University, Greifswald, Germany Hiroyuki Kinouchi University of Yamanashi, Yamanashi, Japan Didier Leys University of Lille, Lille, France David S. Liebeskind University of California, Los Angeles, USA Gregory Y.H. Lip University of Birmingham, Birmingham, UK Xin-Feng Liu Nanjing University, Nanjing, China Eng H. Lo Massachusetts General Hospital, Harvard Medical School, Charlestown, USA Ayrton R. Massaro University of Sao Paulo, Sao Paulo, Brazil Kazuo Minematsu National Cerebral and Cardiovascular Center, Osaka, Japan Joan Montaner Hospital Vall d Hebron, Barcelona, Spain Masao Nagayama International University of Health and Welfare, Atami, Japan Hiroaki Naritomi Senri Chuo Hospital, Osaka, Japan Norbert Nighoghossian Neurology and Neurosurgical Hospital P. Wertheimer, Lyon, France Leonardo Pantoni University of Florence, Florence, Italy Sarah Pendlebury John Radcliffe Hospital, Oxford, UK Fernando Pico Versailles Saint-Quentin-en-Yvelines University, Versailles, France Stefano Ricci Stroke Unit, Città di Castello, Italy Tatjana Rundek University of Miami, Miami, USA Ralph L. Sacco University of Miami, Miami, USA Stefan Schwarz University Medicine Mannheim, Mannheim, Germany Christopher Jan Schwarzbach University Medicine Mannheim, Mannheim, Germany Konstantinos Spengos University of Athens School of Medicine, Athens, Greece Jan Stam University of Amsterdam, Amsterdam, Netherlands Kristina Szabo University Medicine Mannheim, Mannheim, Germany Shunya Takizawa Tokai University School of Medicine, Isehara City, Japan Wai Kwong Tang The Chinese University of Hong Kong, Hong Kong Pierre-Jean Touboul Hospital Bichat, Paris, France Kazunori Toyoda National Cerebral and Cardiovascular Center, Osaka, Japan Shinichiro Uchiyama International University of Health and Welfare Center, Tokyo, Japan Peter Vajkoczy Charité University Medicine, Berlin, Germany Roland Veltkamp Imperial College London, London, UK Konstantinos Vemmos University of Athens, Athens, Greece Denis Vivien Proteases and Pathophysiology of the Neurovascular Unit, Caen, France Joanna M. Wardlaw University of Edinburgh, Edinburgh, UK Katja Wartenberg Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany Marc E. Wolf University Medicine Mannheim, Mannheim, Germany K.S. Lawrence Wong Chinese University of Hong Kong, Hong Kong E-Mail karger@karger.com www.karger.com 2015 S. Karger AG, Basel The Journal Home Page is available at: www.karger.com/ced
Guidelines for Authors Submission Cerebrovascular Diseases only accepts online submissions to: http://mc.manuscriptcentral.com/cedi All further technical instructions can be found there. Presentation of manuscripts should conform with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (www.icmje.org). Recommended reading: Alexandrov AV: How to Write a Research Paper. Cerebrovasc Dis 2004;18:135 138 Alexandrov AV, Hennerici MG: Writing Good Abstracts. Cerebrovasc Dis 2007;23:256 259 How to Improve the Quality of Reports of paral lelgroup randomized trials. The CONSORT Statement. www.consort-statement.org Conditions All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of Cerebrovascular Diseases and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. Conflicts of Interest Authors are required to disclose any sponsorship or funding arrangements relating to their research and all authors should disclose any possible conflicts of interest. Conflict of interest statements will be published at the end of the article. Ethics Published research must comply with the guidelines for human studies and animal welfare regulations. Authors should state that subjects have given their informed consent and that the study protocol has been approved by the institute s committee on human research. Further, they should also state that animal experiments conform to institutional standards. Categories of Manuscripts Original Papers are full-length research papers which will be considered for the journal. Articles cover topics relevant to clinical studies. Basic and experimental work appear only if directly related to clinical issues (max. 3,000 words). Reviews are comprehensive, state-of-the-art papers of important clinical problems. Reviews may be invited by the Editor or they may be unsolicited views (max. 5,000 words). An Abstract is required and should be divided into Background, Summary and Key Messages. Editorials are usually invited by the Editor (max. 1,000 words). Please send suggestions to the Editor. Translational Research in Stroke is a new section in the journal publishing reviews on experimental results with direct clinical implications (max. 3,000 words). Articles in this section may be accompanied by an invited comment (max. 1,000 words). 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General Information ISSN Print Edition: 1015 9770 ISSN Online Edition: 1421 9786 Journal Homepage: www.karger.com/ced Publication Data: Cerebrovascular Diseases is published 12 times a year. Volumes 39, 40, each with 6 issues, appear in 2015. Copyright: 2015 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). 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European PFO Summit October 16, 2015 Hotel Zürichberg Zurich Switzerland wwww.imk.ch/pfo2015 Main Session: PFO-related stroke How to redesign an ideal PFO trail David Kent; Boston, US The RoPE collaboration David Thaler; Boston, US F15357 Jahrestagung 2015 Schweizerische Neurologische Gesellschaft Gastgesellschaften: Schweizerische Gesellschaft für Verhaltensneurologie Schweizerische Gesellschaft für Neurorehabilitation Schweizerische Kopfwehgesellschaft Ärztlicher Beirat der Schweizerischen Multiple Sklerose Gesellschaft Réunion annuelle 2015 Société Suisse de Neurologie Invités: Société Suisse de Neurologie Comportementale Société Suisse de NeuroRééducation Société Suisse pour l étude des céphalées Conseil scientifique de la Société suisse de la sclérose en plaques 29.-30. Oktober 2015 BernExpo Bern www.imk.ch/sng2015 Organized by IMK Institut für Medizin und Kommunikation AG F15358
Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney
JOIN US AT Abstract Submission Deadline: 9 November 2015 Early Registration Deadline: 3 February 2016 Downloaded F15373 by:
Medical Statistics has never been easier! D.E. Matthews. V.T. Farewell Using and Understanding Medical Statistics 5th, revised and extended edition >tuberculosis Alive Dead Control 38 14 Treatment 51 4 > sher.test(tuberculosis) Fisher's Exact Test for Count Data data: tuberculosis p-value=0.008993 David E. Matthews Vernon T. Farewell Using and Understanding Medical Statistics 5th, revised and extended edition exp(a + bx) Pr(Y=1 X=x) = 1 + exp(a + bx) T = (O1 E1)2 E1 + (O2 E2)2 E2 Matthews, D.E. (Waterloo, Ont.); Farewell, V.T. (Cambridge) Using and Understanding Medical Statistics 5th, revised and extended edition XX + 338 p., 48 fig., 103 tab., 2015 CHF 49.00 / EUR 46.00 / USD 54.00 (hard cover + online supplementary material) Online version for institutional purchase Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN 978 3 318 05458 3 (hard cover + online supplementary material) e-isbn 978 3 318 05459 0 ebook available on: Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: The fifth revised edition of this highly successful book presents the most extensive enhancement since Using and Understanding Medical Statistics was first published 30 years ago. Without question, the single greatest change has been the inclusion of source code, together with selected output, for the awardwinning, open-source, statistical package known as R. This innovation has enabled the authors to deemphasize formulae and calculations, and let software do all of the heavy lifting. This edition also introduces readers to several graphical statistical tools, such as Q-Q plots to check normality, residual plots for multiple regression models, funnel plots to detect publication bias in a metaanalysis and Bland-Altman plots for assessing agreement in clinical measurements. New examples that better serve the expository goals have been added to a half-dozen chapters. In addition, there are new sections describing exact confidence bands for the Kaplan-Meier estimator, as well as negative binomial and zero-inflated Poisson regression models for overdispersed count data. The end result is not only an excellent introduction to medical statistics, but also an invaluable reference for every discerning reader of medical research literature. Contents Preface to the Fifth Edition Prefaces to the Previous Editions Basic Concepts Tests of Significance Fisher s Test for 2 2 Contingency Tables Approximate Significance Tests for Contingency Tables Some Warnings concerning 2 2 Tables Kaplan-Meier or Actuarial Survival Curves The Log-Rank or Mantel-Haenszel Test for Comparing Survival Curves An Introduction to the Normal Distribution Analyzing Normally Distributed Data Linear Regression Models for Medical Data Binary Logistic Regression Regression Models for Count Data Proportional Hazards Regression The Analysis of Longitudinal Data Analysis of Variance Data Analysis The Question of Sample Size The Design of Clinical Trials Further Comments regarding Clinical Trials Meta-Analysis Epidemiological Applications Diagnostic Tests Agreement and Reliability References Subject Index Date: Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. The easiest way to order: www.karger.com/medical_statistics Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f: +41 61 306 12 34 www.karger.com KI15406
The interdisciplinary journal for basic and clinical vascular research The new interdisciplinary journal for basic and clinical vascular research Editors J.B. Park, Seoul H. Suzuki, Saitama J.-G. Wang, Shanghai Associate Editors A. Avolio, Sydney, N.S.W. K. Kario, Tochigi J.J. Lee, Daegu A. Yamashina, Tokyo The journal Pulse publishes full-length reviews, mini reviews, and original papers in the field of vascular research. Bringing together the basic and clinical sciences across a range of disciplines, Pulse provides a forum for communication of the latest findings and hypotheses that enhance our understanding of pulsatile processes and vascular disease. The transdisciplinary approach of the journal fosters collaboration in relevant areas including cardiology, nephrology, neurology, endocrinology and diabetology, gerontology and general medicine. All articles are subject to rigorous peer-review in order to maintain the highest standards of publication. The editors welcome submissions from all areas of vascular research, including but not limited to epidemiology, pathophysiology, diagnostics, therapeutics and prevention. Online-first publication ensures prompt dissemination of accepted papers to a multidisciplinary audience with an interest in vascular research. Pulse Founded: 2013 Category: Clinical and Basic Research Fields of Interest: Cardiovascular System, Nephrology Listed in bibliographic services, including PubMed Central, Embase 2016: Volume 4 4 issues per volume Language: English ISSN 2235 8676 e-issn 2235 8668 KF16096 Selected contributions Pediatric Measurement and Considerations: Savant, J.D.; Furth, S.L.; Meyers, K.E.C. (Philadelphia, Pa.) Blood Pressure Variability and Cognitive Function in the Elderly: Jung, H.; Kim, K. (Seoul/Seongnam) Arterial Stiffening and Clinical Outcomes in Dialysis Patients: Kato, A. (Hamamatsu) Lifestyle Factors and Coronary Artery Calcification: Lee, C.-D. (Phoenix, Ariz.); Jae, S.Y. (Seoul) Role of Pulse Wave Velocity in Patients with Chronic Kidney Disease Stages 3 5 on Long-Term Follow-Up: Suzuki, H.; Inoue, T. (Saitama); Dogi, M. (Kyoto); Kikuta, T. (Saitama); Takenaka, T. (Tokyo); Okada, H. (Saitama) Gender Difference in Arterial Stiffness in a Multicenter Cross-Sectional Study: The Korean Arterial Aging Study (KAAS): Kim, J.-Y. (Wonju); Park, J.B. (Seoul); Kim, D.S. (Busan); Kim, K.S. (Daegu); Jeong, J.W. (Iksan); Park, J.C. (Gwangju); Oh, B.H. (Seongnam); Chung, N. (Seoul) on behalf of the KAAS investigators Common Carotid Artery Stiffness Is Associated with Left Ventricular Structure and Function and Predicts First Hospitalization for Acute Heart Failure: Sung, S.-H.; Liao, J.-N.; Yu, W.-C.; Cheng, H.-M.; Chen, C.-H. (Taipei) Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3 5: Suzuki, H.; Inoue, T. (Saitama); Dogi, M. (Kyoto); Kikuta, T.; Takenaka, T.; Okada, H. (Saitama) Clinical Considerations for the Association between Vascular Damage and Chronic Kidney Disease: Tomiyama, H.; Yamashina, A. (Tokyo) More information at www.karger.com/pls
www.karger.com/ced 40 3 4 15 Laudatio 101 The Johann Jacob Wepfer Award 2015 of the European Stroke Conference to Professor Ralph L. Sacco The Johann Jacob Wepfer Award 102 Evolution from Stroke Risk Factors to Brain Health Determinants. 11th Johann Jacob Wepfer Lecture, European Stroke Conference, Vienna, Austria 2015 Sacco, R.L. (Miami, Fla.) Original Papers 114 Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial Sato, S.; Arima, H.; Heeley, E.; Hirakawa, Y.; Delcourt, C.; Lindley, R.I. (Sydney, N.S.W.); Robinson, T. (Leicester); Huang, Y. (Beijing); Morgenstern, L. (Ann Arbor, Mich.); Stapf, C. (Paris); Wang, J. (Tangshan); Chalmers, J.; Anderson, C.S. (Sydney) 121 Age 80 Years Is Not a Contraindication for Intra-Arterial Therapy after Ischemic Stroke Leonard, J.; Frei, D.; Salottolo, K.; Fanale, C.V.; Wagner, J.C.; Whaley, M.; McCarthy, K.; Bellon, R.J.; Loy, D.; Bar-Or, D. (Englewood, Colo.) 129 Phenotypic ASCO Characterisation of Young Patients with Ischemic Stroke in the Prospective Multicentre Observational sifap1 Study Wolf, M.E. (Mannheim); Grittner, U. (Berlin); Böttcher, T. (Rostock); Norrving, B. (Lund); Rolfs, A. (Rostock); Hennerici, M.G. (Mannheim) on behalf of the sifap1 TM investigators 136 Cigarette Smoking and Carotid Plaque Echodensity in the Northern Manhattan Study Yang, D.; Iyer, S.; Gardener, H. (Miami, Fla.); Della-Morte, D. (Miami, Fla./Rome); Crisby, M. (Stockholm); Dong, C. (Miami, Fla.); Cheung, K.; Mora-McLaughlin, C. (New York, N.Y.); Wright, C.B. (Miami, Fla.); Elkind, M.S. (New York, N.Y.); Sacco, R.L.; Rundek, T. (Miami, Fla.) 144 Posterior Circulation Ischemic Stroke Caused by Arterial Dissection: Characteristics and Predictors of Poor Outcomes Chang, F.-C.; Yong, C.-S.; Huang, H.-C.; Tsai, J.-Y.; Sheng, W.-Y.; Hu, H.-H.; Chung, C.-P. (Taipei) 151 Acute Silent Brain Infarction in Monocular Visual Loss of Ischemic Origin Lauda, F.; Neugebauer, H.; Reiber, L. (Ulm); Jüttler, E. (Ulm/Aalen) 157 Plasma Biomarkers of Inflammation, Endothelial Function and Hemostasis in Cerebral Small Vessel Disease Wiseman, S.J.; Doubal, F.N.; Chappell, F.M.; Valdés-Hernández, M.C.; Wang, X. (Edinburgh); Rumley, A.; Lowe, G.D.O. (Glasgow); Dennis, M.S.; Wardlaw, J.M. (Edinburgh) 165 Ultrasound Characteristics of Symptomatic Carotid Plaques: A Systematic Review and Meta-Analysis Brinjikji, W.; Rabinstein, A.A.; Lanzino, G.; Murad, M.H.; Williamson, E.E. (Rochester, Minn.); DeMarco, J.K. (East Lansing, Mich.); Huston III, J. (Rochester, Minn.) 175 Real-World Experience with Insertable Cardiac Monitors to Find Atrial Fibrillation in Cryptogenic Stroke Ziegler, P.D. (Mounds View, Minn.); Rogers, J.D. (La Jolla, Calif.); Ferreira, S.W. (St. Louis, Mo.); Nichols, A.J. (Columbus, Ohio); Sarkar, S.; Koehler, J.L.; Warman, E.N. (Mounds View, Minn.); Richards, M. (Toledo, Ohio) 182 Collateral Circulation Predicts the Size of the Infarct Core and the Proportion of Salvageable Penumbra in Hyperacute Ischemic Stroke Patients Treated with Intravenous Thrombolysis Rusanen, H. (Oulu); Saarinen, J.T. (Vaasa); Sillanpää, N. (Tampere) 191 Cortical Superficial Siderosis and Risk of Bleeding after Thrombolysis for Ischemic Stroke Gattringer, T.; Eppinger, S.; Beitzke, M.; Wuensch, G.; Niederkorn, K.; Deutschmann, H.; Fazekas, F.; Enzinger, C. (Graz) Stroke Note 198 Neurothrombectomy in the Management of Acute Ischemic Stroke Lattanzi, S.; Silvestrini, M. (Ancona)