Fertility / IVF Product Catalogue

Fertility / IVF Product Catalogue 2013-2014

Welcome to Esco Pictured: Esco Micro Pte. Ltd. is headquartered in Singapore, a modern city state located in Southeast Asia with a population of more than 4 million. From Singapore, Esco manages operations throughout the world. Esco represents innovation and forward - thinking designs, which are all coupled with the highest standard quality since 1978. The Esco Group of Companies is a global life sciences tools provider with sales in over 100 countries. The group is active in lab, medical and pharmaceutical equipment. Manufacturing facilities are located in Asia and Europe. R&D is conducted worldwide spanning the US, Europe and Asia. Sales, service and marketing subsidiaries are located in 12 major markets worldwide. Regional distribution centers are located in the US, UK, and Singapore. We operate under ISO 9001 and ISO 14001 certified Quality and Environmental Management Systems. Esco Medical is one of the divisions of the Esco Group of Companies, the other two being the laboratory and pharmaceutical equipment divisions. Esco is now targeting innovative technological solutions for fertility clinics and laboratories. Esco Medical is positioned to become a leading manufacturer and innovator of high-quality equipment such as long-term embryo incubators, time lapse benchtop incubators, ART workstations, anti vibration table, gas analyser and etc. Most products are designed in Denmark and made in the EU. The primary focus of this division is to increase pregnancy success rates. 2

Miri ART / IVF TL Quick (Time Facts Lapse) Benchtop Incubator Time Lapse Monitoring of Embryo Development The most user friendly time lapse benchtop incubation system on the market, with the best sample protection and the industry s lowest total cost of ownership. Key Features 6 completely separate culture heat chambers with heated lid Time lapse monitoring with 5 minutes (adjustable) interval 1 CultureCoin per Miri TL chamber; 1 4 embryos per CultureCoin = 84 embryos total and O 2 regulation system HEPA + VOC filtration Designed in Denmark Made in the E.U. EN 61010-1:2010 3 Components of Miri TL System Miri TL Incubator Miri TL Server Secure and reliable storage of time lapse data Miri TL Viewer Patient data organization Embryo annotation Powerful yet easy to use tools for selection Miri TL Viewer screenshots Miri TL main screen showing general incubation parameters Onboard data logger records all incubation chamber parameters Built-in standard ph meter (BNC-type) is accessed from the ph meter screen Miri TL incubator viewers screenshots Annotations of the embryo are stored. When an event occurs, the user simply selects the event from the events list. If two events relate to some developmental stage, the period between the milestone events is highlighted with a useful color fill. When a decision is to be made, the user needs only to click a button. A resulting transfer map gives the user an easy method to identify embryos that have been selected for either embryo transfer, cryopreservation, or discarding. Silent Embryo Hypothesis Parents are vigilant when it comes to their children s safety. Similarly, Miri TL gives importance to monitoring the embryo during its development. The Miri TL enables time-lapse image monitoring of the growing embryos and thus gives the embryologist a valuable tool in ensuring the most viable embryos are selected. Common Stressors: Temperature fluctuations Gas concentration fluctuations Non-optimal ph Volatile Organic Compounds (VOCs) 3

Miri Time Lapse CultureCoin The Miri Time Lapse CultureCoin is a specially designed culture dish that enables the Esco Miri Time Lapse incubator to take photos of incubating embryos. Miri Time Lapse incubator for IVF Advanced Temperature Regulation Advanced + O 2 Regulation O 2 from atmosphere Miri Time Lapse CultureCoin The Miri TL has an advanced temperature regulation system. There are 6 completely High Quality Recirculated Airstream Gas mixing Recirculation HEPA+VOC filtration independent chambers (with heated lid) to avoid crossover of heat. N 2 UV sterilization Incubation chambers Miri TL Technical Specifications Total Dish Capacity 6x CultureCoin dishes, 14 embryos per dish, total of 84 embryos Temperature Control Range 25-40ºC Control Range 1.9-10% O 2 Control Range 20-5% Input Gases and Pressure Pure and pure N 2, 0.6 bar (8.7psi) Overall Dimension 950 mm x 600 mm x 370 mm (37.4 x 23.6 x 14.6 ) Ordering Information* MRI-TLA-8 MRI-TLA-9 Miri Time Lapse Incubator System, 230 V Miri Time Lapse Incubator System, 115 V *Includes Miri TL Incubator, Miri TL Server, Miri TL Viewer and 1pc HEPA + VOC filter, and 2pcs In-line Filter Accessories MRA-1007 MRI-CCA HEPA + VOC filter (to be replaced every 3 months) CultureCoin for Time Lapse of 14 embryos 4

Miri ART / IVF Multi-room Quick FactsIncubator A ground-breaking design for IVF The Miri is a certified EU Class IIa Medical Device and it is also the only incubator that has been certified to the 3rd edition of the IEC/EN 60601 standard. It is thus no wonder that the remarkable characteristics of the Miri make it an entirely exceptional incubator for in vitro fertilization applications. Designed in Denmark Made in the E.U. Key Features 6 completely separate heating chambers Advanced temperature regulation + heated lid and O 2 regulation HEPA + VOC filtration UV-C Filtration airstream Data logging Easy validation Built-in ph meter (BNC) Audible and visual alarms Stackable with accessory stacking frame Miri Multi-room Incubator Technical Specifications Total Dish Capacity Falcon, Nunc, or Vitrolife brands 24x IVF 4-well 24 x 60 mm Petri Dishes (0.9 x 2.4 ) 48 x 35 mm Petri Dishes (1.9 x 1.4 ) Temperature Control Range 25-40ºC Control Range 1.9-10% O 2 Control Range 20-5% Input Gases and Pressure Dimension and Weight Shipping Dimension and Weight Pure and Pure N 2, 0.6 bar (8.7 psi) 700 mm x 580 mm x 150 mm (27.6 x 22.8 x 5.9 ), 35 kg (77.2 lbs) 840 mm x 735 mm x 300 mm (33.1 x 28.9 x 11.8 ), 40 kg (88.2 lbs) Ordering Information* MRI-6A10-8F MRI-6A10-9F MRI-6A10-8N MRI-6A10-9N MRI-6A10-8V MRI-6A10-9V Miri Incubator, 230 V, for Falcon Dishes Miri Incubator, 115 V, for Falcon Dishes Miri Incubator, 230 V, for Nunc Dishes Miri Incubator, 115 V, for Nunc Dishes Miri Incubator, 230 V, for Vitrolife Dishes Miri Incubator, 115 V, for Vitrolife Dishes *Includes Data Logger Software, 1pc HEPA + VOC Filter, 2pcs In-Line Filters Accessories MRA-1007 MRI-1014 HEPA + VOC filter (to be replaced every 3 months) Stacking frame for 2x Miri units 5

Miri Accessories HEPA + VOC Filter Order Code: MRA-1007 Ensures that clean and VOC-free air is supplied to the incubation chambers. Advisable to be replaced every 3 months. In-line Filters Order Code: MRA-1001 Filters gas input. Order code is for 2 pcs external filters and 2 pcs internal filters (not shown in the image). Special Lid for ph Probe Order Code: MRA-1016 Allows ph reading while keeping gas contained. Note: With some types of ph probes, ph measurement can drift. Ensure that a suitable probe or procedure is used (ph probe not included). Micro ph Probe Order Code: MRI-MPH Capable of taking ph probe measurement with microdrop volumes of media. Buffers not included. Disinfectant Spray Order Code: DIS-500 Safely and effectively disinfect incubators and other general surfaces. Stacking Frame for 2x Miri Unit Order Code: MRA-1014 Space-saving efficiency is provided by the sturdy solid metal frame designed to stack 2 Miri incubator units. 6

CelCulture Incubators Cradle for Beautiful Cells CelCulture incubators are widely used in scientific research to grow and maintain cell cultures. Typical fields of application include tissue engineering, in vitro fertilization, neuroscience, cancer research, stem cell research, regenerative medicine, and other mammalian cell research. Sleek, reliable and intuitive, Esco CelCulture Incubators provide well-rounded sample protection. Key Features ULPA filtration system 90 C moist heat decontamination cycle, validated by HPA-UK Cost effective SUPPRESSED O 2 MODEL MODELS CCL-170T-8-Cu CCL-170T-9-Cu CCL-240T-8-Cu CCL-240T-9-Cu DESCRIPTION CelCulture Incubator, 170L, IR Sensor, Control, O 2 Control ULPA, Moist Heat Decon, 230VAC 50/60HZ CelCulture Incubator, 170L, IR Sensor, Control, O 2 Control ULPA, Moist Heat Decon,115VAC 50/60HZ CelCulture Incubator, 240L, IR Sensor, Control, O 2 Control ULPA, Moist Heat Decon, 230VAC 50/60HZ CelCulture Incubator, 240L, IR Sensor, Control, O 2 Control ULPA, Moist Heat Decon,115VAC 50/60HZ Laminar Flow Cabinet Product Protection at your Fingertips Airstream Vertical Laminar Flow Clean Benches offer proven protection for your samples and processes where operator protection is required. Vertical laminar flow offers certain tangible advantages over horizontal flow clean benches (which may be the convention to some parts of the world), such as lower energy consumption (40% of conventional system) levels through the use of exclusive motorized impeller technology and less airflow turbulence (especially when large objects are used on the workzones). In fact, the negative pressure filter mounting system employed on these models is widely recognized to be superior to that of conventional horizontal flow clean benches. Key Features ISO Class 3 workzone Airflow monitoring Energy saving Model AVC-2D_ AVC-3D_ AVC-4D_ AVC-5D_ AVC-6D_ Nominal Size 0.6 m (2 ) 0.9 m (3 ) 1.2 m (4 ) 1.5 m (5 ) 1.8 m (6 ) External Dimensions (W x D xh) Without Base Stand With Optional Base Stand 711mm (28 ) 730 x 770 x 1250 mm 28.7 x 30.3 x 49.2 730 x 770 x 1961 mm 28.7 x 30.3 x 77.2 1035 x 770 x 1250 mm 40.7 x 30.3 x 49.2 1035 x 770 x 1961 mm 40.7 x 30.3 x 77.2 1340 x 770 x 1250 mm 52.8 x 30.3 x 49.2 1340 x 770 x 1961 mm 52.8 x 30.3 x 77.2 1645 x 770 x 1250 mm 64.8 x 30.3 x 49.2 1645 x 770 x 1961 mm 64.8 x 30.3 x 77.2 1950 x 770 x 1250 mm 76.8 x 30.3 x 49.2 1950 x 770 1961 mm 76.8 x 30.3 x 77.2 Internal Work Area Dimensions (W x D xh) 660 x 700 x 695 mm 26.0 x 27.6 x 27.4 965 x 712 x 695 mm 38.0 x 28.0 x 27.4 1270 x 712 x 695 mm 50.0 x 28.0 x 27.4 1580 x 712 x 695 mm 62.2 x 28.0 x 27.4 1884 x 712 x 695 mm 74.2 x 28.0 x 27.4 Internal Work Area Space 0.39 m 2 (4.2 sq.ft.) 0.59 m 2 (6.3 sq.ft.) 0.79 m 2 (8.5 sq.ft.) 0.98 m 2 (10.5 sq.ft.) 1.18 m 2 (12.7 sq.ft.) 7

Fertilisafe Multi-Zone ART Workstation The most advanced workstation in its class It is designed for use in applications that require a high level of control over environmental conditions. Applications can range from animal embryo culture in research to human embryo manipulation done in fertility laboratories. Key Features Multiple heating zone work surface Surveillance system with data logging Laminar airflow with ULPA filtration Low noise and vibration Provision for microscope integration Humidification system Variable configuration Designed in Denmark Fertilisafe TM Technical Specifications MAW-4D_ MAW-6D_ MAW-4D_DUAL Work Area Dimensions (Width x Depth x Height) External Dimension without Support Stand (Width x Depth x Height) External Dimension with B type Support Stand (Width x Depth x Height) 1260 x 500 x 710 mm (49.6 x 19.7 x 28 ) 1340 x 640 x 1300 mm (52.8 x 25.2 x 51.2 ) 1340 x 640 x 2160 mm (52.8 x 25.2 x 85 ) 1870 x 500 x 710 mm (73.6 x 19.7 x 28 ) 1950 x 640 x 1300 mm (76.8 x 25.2 x 51.2 ) 1950 x 640 x 2160 mm (76.8 x 25.2 x 85 ) Laminar Airflow Velocity Average of 0.21 m/s or 41 fpm (+/- 20%) Filter Efficiency Minimum: 999.9991% at 0.3 µm / 99.9984% at 0.12 µm / 99.9982% at MPPS Typical: 999.9998% at 0.3 µm / 99.998% at 0.12 µm / 99.9987% at MPPS Noise Level (as per IEST) 47 dba 48 dba Pre-filter Disposable and non-washable polyester fibers with 85% arrestance / EU3 rated Heating System Smart power injection electrical heating, 9+1 zones Smart power injection electrical heating 2 x (9+1) zones Temperature Accuracy Temperature Uniformity ± 0.2ºC ± 0.2ºC Included Advance Features Integrated Humidification System HS-1 Surveillance System with Data Logger AIO PC Heated Glass Stage Transmitted Light Source SC-1 (with bulb) 5x PT1000 Validation Ports Dual Integrated Humidification System HS-1 Surveillance System with Data Logger AIO PC 2x Heated Glass Stage 2x Transmitted Light Source SC-1 (with bulb) 10x PT1000 Validation Ports Included Accessories 1x Water Bottle fo HS-1, including tubing 1x Sample Carry Tray 1x Humidified Glass Plastic Cover 2x Water Bottle fo HS-1, including tubing 2x Sample Carry Tray 2x Humidified Glass Plastic Cover Microscope Provision Included for 1 microscope Included for 2 microscopes Microscope Support Stand Required, Not included (see Ordering Information) Required, Not included (see Ordering Information) 8

Fertilisafe TM Components Multi-Zone heating system The 10 zones each have their own heating mechanisms and temperature sensors. This allows excellent uniformity. A Accuracy: ± 0.2ºC Uniformity: ± 0.2ºC B Surveillance system with touchscreen monitor (AIO PC) The surveillance system gives the user the ability to see the temperature of all the zones in real time. The surveillance system is also a data logger and stores parameter data and alarm events. The touchscreen monitor is a fully functional Windows PC. It has WiFi and a USB port. 6 completely separate heating chambers Advanced temperature regulation + heated lid and O 2 regulation C Microscope provisional features* Most common stereomicroscopes can be integrated in the Fertilisafe TM. This includes Nikon, Olympus, Carl Zeiss, Leica models. Lighted bases cannot be integrated; the Esco SC-1 light source is designed for use with the workstation and thus will outperform lighted bases, which are not specified for this application. Important: The microscope base part number must be provided to Esco to ensure proper fitting. *Provision for integration of stereomicroscope SC-1 Light Source HS-1 Humidification system D C1 Warmed glass stage System guide C2 MAW-#D# Code D system includes: A B C C1 C2 D MAW-#F# Code F system includes: A C C1 C2 D 9

Ordering Information CODE DESCRIPTION MAW-4D9 MAW-4D8 MAW-4D9- SINGLE / DUAL / MP MAW-4D8- SINGLE / DUAL / MP Multi-Zone ART Workstation 4 ft (1.2 m), 110 V, 50 / 60 Hz Multi-Zone ART Workstation 4 ft (1.2 m), 220 V, 50 / 60 Hz Multi-Zone ART Workstation 6 ft (1.8 m), 110 V, 50 / 60 Hz Multi-Zone ART Workstation 6 ft (1.8 m), 220 V, 50 / 60 Hz MICROSCOPE PROVISION CODE DESCRIPTION 6 ft MAIN BODY SUFFIX (explanation) NIKONCPSNULL Nikon C-PS NIKONCPS160 Nikon C-PS 160 OLYMPUSSZ(X)ST Olympus SZX-ST OLYMPUSSZ(TWO)ST Olympus SZ2-ST ZEISSTANDN Zeiss Stand N SINGLE - Single Stereomicroscope Provision DUAL - Dual Stereomicroscope Provision MP - Stereomicroscope + Inverted microscope / micromanipulator ESCOSCOPE Esco Stereomicroscope MS-1 SUPPORT STAND DESCRIPTION SMC - 4A0 4 ft MAW Support Stand with castor wheels, overall height 711 mm (28 ) SMC - 6A0 6ft MAW Support Stand with castor wheels, overall height 711 mm (28 ) SML - 4A0 4 ft MAW Support Stand with leveling feet, overall height 711 mm (28 ) SML - 6A0 6 ft MAW Support Stand with leveling feet, overall height 711 mm (28 ) SMC - 4B0 4 ft MAW Support Stand with castor wheels, overall height 860 mm (33.9 ) SMC - 6B0 6 ft MAW Support Stand with castor wheels, overall height 860 mm (33.9 ) SML - 4B0 4 ft MAW Support Stand with leveling feet, overall height 860 mm (33.9 ) SML - 6B0 6 ft MAW Support Stand with leveling feet, overall height 860 mm (33.9 ) 4 ft SINGLE Configuration ORDER CODE: MAW-4D8 (230 V), MAW-4D9 (115 V) 4 ft width configuration with provision for single stereomicroscope 6 ft DUAL Configuration ORDER CODE: MAW-6D8-DUAL (230 V), MAW-6D9-DUAL (115 V) 6 ft width configuration with provision for two stereomicroscope 10

Anti Vibration Table Isolate Microscope from External Vibrations Inverted miroscopes with micromanipulators are used for Intracytoplasmic Sperm Injection (ICSI) and must be completely isolated from external vibrations. The AVT-1 is specially made for purposes of providing effective passive-type damping of vibrations. Technical Specifications Overall Dimensions (W x D x H) Weight Material Float Dimension AVT-1 1200 x 800 x 800 mm (47.2 x 31.5 x 31.5 ) 70 kg (154 lbs) Material Powder painted mild steel, Stainless steel and glass 540 mm x 340 mm (21.26 x 13.39 ) Note: AVT-1 is designed to be easy to use and almost maintenance free Designed in Denmark Made in the E.U. Miri GA (Gas Analyser) Desktop /O 2 & Temperature Validation Unit The Miri GA contains high precision quality components. These components are chosen to ensure a high durability and performance of the equipment. Key Features Constantly validate up to 6 x / O 2 incubators Controllable flow rate Monitor up to 6 x PT1000 sensors 6 ports for sequential gas samples Gas feedback returns sampled gas to incubator or exhaust As a validation unit, Miri GA can provide: Parameter data logging Audible and visual alarms Adjustable alarm thresholds Connected to a PC, the logging software will document parameters and optionally send e-mail alarms if set up. Designed in Denmark Made in the E.U. Miri GA Technical Specifications Input ports Output ports Shipping Dimension and Weight 6x PT1000 ports for temperature monitoring 1x gas feedback port 440 mm x 430 mm x 240 mm (17.3 x 16.9 x 9.4 ), 15 Kg (33.1 lbs) Ordering information* MRI-GA Miri GA / O 2 & Temperature Validation Unit, 115V / 230V *Includes data logging software, 1 pc PT1000 cable, 1 pc gas connection tube, and 1 pc gas feedback tube 11

Index of order codes of notable Esco Medical Products CODE DESCRIPTION PAGE MRI-TLA-8 Miri Time Lapse incubator system, 230 V Page 3-4 MRI-TLA-9 Miri Time Lapse incubator system, 115 V Page 3-4 MRI-6A10-8N Miri Multi-Room benchtop incubator, 230 V, with plates for Nunc dishes Page 5-6 MRI-6A10-9N Miri Multi-Room benchtop incubator, 115 V, with plates for Nunc dishes Page 5-6 MRI-6A10-8F Miri Multi-Room benchtop incubator, 230 V, with plates for Falcon dishes Page 5-6 MRI-6A10-9F Miri Multi-Room benchtop incubator, 115 V, with plates for Falcon dishes Page 5-6 MRA-1014 Stacking frame for 2x MRI-6A10 Page 6 MRA-1007 HEPA + VOC filter for MRI-TLA or MRI-6A10 Page 6 MRA-1001 In-line filter set (2x internal, 2x external) for MRI-TLA or MRI-6A10 Page 6 MRA-1016 Special lid for ph probe Page 6 MRI-MPH Micro-pH probe (BNC connector) Page 6 DIS-500 Disinfectant spray (500 ml spray bottle) Page 6 MAW-4D8 Fertilisafe Multi-Zone Workstation, 230 V, 4 ft, complete system Page 8-10 MAW-4D9 Fertilisafe Multi-Zone Workstation, 115 V, 4 ft, complete system Page 8-10 MAW-6D8 Fertilisafe Multi-Zone Workstation, 230 V, 6 ft, single microscope, complete system Page 8-10 MAW-6D9 Fertilisafe Multi-Zone Workstation, 115 V, 6 ft, single microscope, complete system Page 8-10 MAW-4F8 Fertilisafe Multi-Zone Workstation, 230 V, 4 ft, with no surveillance system and monitor Page 8-10 MAW-4F9 Fertilisafe Multi-Zone Workstation, 115 V, 4 ft, with no surveillance system and monitor Page 8-10 MAW-6F8 Fertilisafe Multi-Zone Workstation, 230 V, 6 ft, with no surveillance system and monitor Page 8-10 MAW-6D9 Fertilisafe Multi-Zone Workstation, 115 V, 6 ft, with no surveillance system and monitor Page 8-10 AVT-1 Antivibration table for inverted microscope setup (ICSI) Page 11 MRI-GA Miri GA / O 2 & Temperature validation unit, 115 V / 230 V Page 11 Asia (Headquarters) Esco Micro Pte Ltd 21 Changi South Street 1, Singapore Tel +65 6542 0833 Fax +65 6542 6920 csis-medical@escoglobal.com www.medical.escoglobal.com Europe Esco GB Ltd Unit 20, Parkers Close, Downton Industrial Estate Downton, Wiltshire SP5 3RB Tel: +44 (0) 1725 514 555 Fax: +44 (0) 1725 514 551 mark.darton@escoglobal.com www.escogb.com North America Esco Technologies, Inc. 2940 Turnpike Drive, Units 15-16 Hatboro, PA, USA Tel: 215 441 9661 Fax: 215 441 9660 nick.wang@escoglobal.com www.us.escoglobal.com Hand in hand in achieving high fertility success rates. 9010177_IVF Workstation_Medical_Combined Catalogue_A4_vA_07/13 Esco can accept no responsibility for possible errors in catalogues, brochures and other printed materials. Esco reserves the right to alter its products and specifications without notice. All trademarks and logotypes in this material are the property of Esco and the respective companies. Esco Global Offices: Manama, Bahrain Beijing, China Chengdu, China Guangzhou, China Shanghai, China Bangalore, India Delhi, India Mumbai, India Jakarta, Indonesia Osaka, Japan Kuala Lumpur, Malaysia Melaka, Malaysia Manila, Philippines Singapore Seoul, South Korea Salisbury, UK Philadelphia, PA, USA Hanoi, Vietnam 7