3200i Tablet press 1 2. High performance with optimal cost-performance ratio. 3200i.

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3200i Tablet press 1 2 High performance with optimal cost-performance ratio 3200i www.fette-compacting.com

The Fette Compacting 3200i is a double sided rotary tablet press suitable for the production of medium to very large batches. It efficiently produces both single- and bi-layer tablets. Maximum flexibility and reliable technology are the distinguishing features of this tablet press segment technology by Fette Compacting included. In combination with exchangeable turrets, the 3200i guarantees optimal pro ductiv ity even when switching between different tablet types. The 3200i combines 100 per cent economic viability with the top technology of the market and technology leader in this market sector. TECHNOLOGY covers all products in the tableting technology; from tablet presses, to process equipment and tableting tools. SERVICE includes all services related to machinery and equipment, such as: spare parts supply, installation, system upgrades and technical field service. COMPETENCE is the generic term for our process-related services. This includes our training programs and compression trials, as well as application and OEE consulting, and engineering.

3200i Tablet press 2 3 The principal advantages at a glance Features Benefits + High-performance rotary tablet press, effective in practice + Productive, precise, reliable in operation, robust + Excellent cost / benefit ratio + Best TCO (Total Cost of Ownership) figures + Exchangeable die turret + Format change over is very fast + Exchangeable segment turret + High yield, simplified cleaning + Large number of stations on the turret + Maximum profitability with large batches + Operator terminal with 15" touch screen + Easy to handle and operate + Wide range of accessories and process equipment + Remarkable flexibility and range of applications + Maximum security and monitoring + 24-hour unmanned operation + Automatic process monitoring + Future-proof basic equipment and software + High-quality Fette Compacting standard components + Conforms to GMP, GAMP and FDA

High productivity through double capacity Double tablet output or 2-layer compression products + 2 filling units (Fill-O-Matics) + 2 pre-compression and main compression stations + 2 tablet discharges + Up to 110 punch stations in the segment turret + Up to 79 punch stations in the die turret Extremely high performance figures through optimized design + More than 1 million tablets/h + 24-hour unmanned production + Reduction of down-time through the use of a second exchangeable turret or a second segment set + Increased yield through segment turret + Increase in annual yield through use of the optimum turret in relation to the tablet diameter + Shortening of cleaning time through easy accessibility and assembly without special tools + Simple and flexible integration into production lines Two identically sized pre-compression and main compression stations on one turret: double capacity

3200i Tablet press 4 5 Fully modular system, with a wide range in optional process equipments + 3200i tablet press with exchangeable die or segment turret + 15" touchscreen with clearly structured user interface + Electrical cabinet with VME bus computer + Process equipment: PKB stearate distributor GRATEX (dust removal and de-burring of tablets) VERTICAL DEDUSTER (de-dusting and vertical transport for further treatment stages) CHECKMASTER 4.1 (in-process control of tablet diameter, thickness, weight and hardness) WEIGHTMASTER 4.1 (alternative, for weightchecking only) METALCHECK (inspection and rejection of tablets contaminated by metal) LOADING CENTER (tablet filling unit) HANDLING SYSTEM for turret exchange

High flexibility with exchangeable segment turrets Turret with patented properties + Complete die table package is removed, including all cams and punches, patented + Adjustment to changing production requirements in very little time + Flexible fitting through standardized parts + Lower punch secured by patented punch brake against falling out during exchange + Turret optionally manufactured of stainless steel or hard-chromed increased resistance to abrasion increased resistance to chemicals reduced surface roughness, smooth surfaces fast cleaning in the washing centre

3200i Tablet press 6 7 Great simplification achieves powerful performance potentials + Die table segments for all current Fette Compacting tablet presses + All the positive features of conventional exchangeable turrets are retained + More stations bring up to 50 % increase in yield, depending on tablet diameter + Radically shortened fitting time through an 88 % reduction in the number of parts + Simplified cleaning without the bolts and holes of a standard die plate + More than 50 % reduction in the loss of product, depending on product properties, through smooth surfaces and the absence of gaps between the die table and the dies + Reduced wear through optimum material properties + Simplified logistics through fewer parts + Lower ejection forces bring higher tablet quality due to smooth surfaces fast cleaning in the washing centre 2-layer tablets + 2-layer tablets in a wide range of formats + Easy refitting from single- to bi-layer + Optimum layer separation

Optimum operation with the latest hardware and software Powerful operating terminal simplifies secure operation + 15" touchscreen for an improved overview + Powerful industrial PC offers ideal data processing and storage + Windows operating system ensures compatibility + Uninterruptible power supply protects against data loss + Computer-controlled, user-friendly adjustment of the terminal height, patented + Service Portal optional available Greatly simplified press operation + Improved operation with the aid of easily understood icons and buttons + Structured diagnostic messages for rectifying malfunctions (expert system) + Product-specific magnitudes can be displayed in addition to parameter lists + Help texts provide descriptions of parameters and diagnostic messages + All production-relevant data are brought together in one view + All batch data can be examined + Different user levels available for security + Full conformity with 21 CFR Part 11 Detailed documentation + Any and all operator inputs and changes are recorded in a change log + Process data documentation (production record/result record) + Operating status documentation (diagnostic record) + Complete overview with automatic analysis + Batch record + Optional version management

3200i Tablet press 8 9 Maximum security and monitoring with optimized control Reliable control + Direct control of all motor driven adjustments on the machine + Optimal monitoring through data collection from all measuring points + High-speed data transfer with the inprocess control and operator interface via Ethernet TCP/IP + Clearly structured control loops + Highly sensitive measuring points + Extremely stable regulation for best tablet quality + Incorporation of production-specific data into the control process + Precise single-tablet ejection based on compression force ensured + Ejection force measurement for production monitoring + Measurement of punch tightness + Patented monitoring for punch protection + Individual quality control, with samples drawn for specific punches + Extraction control and monitoring for dust-free compression compartment Safety-oriented electrical cabinet + Flexible separation of grey and white areas + The most up-to-date computer, real-time + Total encapsulation of electronic components from surrounding air + All assemblies are easily accessible + Display of current status via LEDs + Calibration unit allows control loop adjustments at any time + Easy exchange of computer components + Maximum resistance to interference and electromagnetic compatibility + Power and control circuitry are strictly isolated + Unique cooling design using two separate circulation systems + Temperature reduction through standby operation

Divided structure with encapsulated compression compartment Modular mechanical design achieves functional benefits + Optimized strength (FEM calculation) for long service life + Maximum operating security + Ideal working safety + Low maintenance costs through long service intervals + Modular design with separation into 4 sections: head section compression compartment middle area drive area Dust-free head section + Plug-in, easily fitted dust extraction + Efficient dust extraction with optional vacuum regulation + Separate material feed essential for 2-layer tablets + Construction of the whole machine completed by sound insulation through sandwich construction and sound-insulating pillars; less than 80 db, depending on production data all cladding suspended to minimize vibration reinforced window flaps, modified flap seals Optimally aligned pressing equipment + Precision turret mounting + Turret and turret shaft both form-fitting + All compression stations of the same construction + Adjustment of the upper compression rollers through an eccentric unit + Lower compression rollers adjusted by servo motors + Compression stations can be moved easily + Pre- and main compression rollers have the same dimensions for long dwell times + Pre- and main compression force can be up to 100 kn

3200i Tablet press 10 11 Encapsulated compression area + GMP conform designed compression compartment + Ideal visibility through window flaps with no frames, double-glazed + Accessibility from all 4 sides + Conforms to the highest GMP standards + Easily cleaned and easily exchanged push-in elements shorten fitting times + Smooth surfaces for best possible cleaning The latest filling system + Fill-O-Matic with proven three-chamber system easily dismantled easily cleaned filling and dosage wheel easily exchanged sealing segments matching the tablet diameter brings an enormous reduction in product loss optionally available in washable stainless steel Drive chamber optimized for fittings + Suspended base plate with vibration insulation + High performance torque drive unit + Precisely tapered roller bearings + Strict separation of drive and compression areas + Removable, without tools, double-lip seals on the window flaps + Filling hopper easily removed by twisting and lowering

Single sided production optional Continuous production + If a packaging machine is attached to each side of a 3200i, it can happen that one of them stops, for reasons associated with the packaging machine, while the other one continues to run. The single-sided production operation option makes it possible to continue production at just one of the stations of the tablet press. + Advantage when producing single-layer tablets: if the tablet press is fed from two containers, which will almost never become empty at exactly the same time, then when one of the containers has run out it is possible to continue production from the material remaining in the second. + Since the 3200i is a symmetrical double press, the single-sided production operation function can also be used if components on one side fail, in order to continue operation with the other half.

3200i Tablet press 12 13 Dimensions 908 Air outlet Main switch 1600 ±100 10 ca. 778 ca. 2073 1800 1202 ca. 906 MOK 1248 ca. 2024 ca. 2114 Terminal 100 kg Gratex 36 kg 900 Dedusting 50 m³ / h Switch cabinet 350 kg 467 Machine 4800 kg 1136 Cable L = 3 m 1 Ø 27 1 Ø 18 1 Ø 17 1 Ø 15 1 Ø 12 L = 5 m 1000 560 Upper cable inlet (90 200) (Option) Lower cable inlet (140 240) 4 12 kn 1136 Foundation loading Mains In- and outlet air for motor cabinet Pressure air min 6 bar for Option: air rejectsystem o 650 Deduster 700 900 m²/h 900 mm WS Clamp DN 2,5" 562 Air inlet 127 57 Ø60 9 9 490 490 57 562 127 2500 1541 1336 Required floor space for change of die plate Handlingsystem 340 kg Main 400/440/480 V 50 60 Hz Connection 4 6 mm² on floor 4 10 mm cable conduit o 1390 o 3110

Technical Data Die (D) / Segments (S) D D D D D Number of punch stations 79 73 61 49 49 Punch type FS19/EU19 FS19/EU19 FS19/EU19 EU1" EU1"-441 BBS TSM/IPT 19 BB TSM/IPT 19 B TSM/IPT 1" D Tablet output units/h min. 142,200 131,400 109,800 88,200 88,200 max. 1,137,600 1,051,200 878,400 470,400 470,400 Max. compression force 1* kn 100 100 100 100 100 Max. compression force 2* kn 100 100 100 100 100 Max. compression force 3* kn 100 100 100 100 100 Max. compression force 4* kn 100 100 100 100 100 Max. Tablettendurchm. mm 11 13 18 25 25 Max. filling depth 1st layer mm 20 20 20 22 22 Pitch circle diameter mm 680 680 680 680 680 Turret rotation speed min. min -1 15 15 15 15 15 max. min -1 120 120 120 80 80 Matrizendurchmesser mm 22 24 30.16 38.1 38.1 Die-/segment height mm 22.225 22.225 22.225 23.8 23.8 Punch shaft diameter mm 19 19 19 25.35 25.35 Punch length Upper/lower punch mm 133.6 133.6 (133.35) 133.6 (133.35) 133.6 (133.35) 133.6 Upper punch insertion depth mm 1 4 (8**) 1 4 (8**) 1 4 (8**) 1 4 (8**) 1 4 (8**) Dimensions mm 1,390 1,390 2,024 Weight kg Tablet press 4,500 kg, operating terminal 100 kg, switch cabinet 350 kg Electrical supply parameters Operating voltage 400 480 V, 50/60 Hz, power consumption 18 kw Theoretical values or technical limits: These can vary in practice, according to product and application. Tablet thickness is a size dependent on product and can strongly vary. * limited by punch properties; ** 2-layer-operation by Fette Compacting GmbH This publication may not be reprinted in whole or part without our express permission. All right reserved. No rights may be derived from any errors in content or from typographical or typesetting errors. Diagrams, features and dimensions represent the current status on the date of issue of this leaflets. We reserve the right to make technical changes. The visual appearance of the products may not necessarily correspond to the actual appearance in all cases or in every detail.

3200i Tablet press 14 15 D S S S S S 49 110 75 55 55 45 EU35 FS12 FS19/EU19 TSM/IPT 19 EU1" TSM/IPT 1" EU1"-441 EU35 66,600 396,000 135,000 99,000 99,000 81,000 355,200 1,584,000 1,080,000 528,000 528,000 432,000 100 25 100 100 100 100 100 25 100 100 100 100 100 25 100 100 100 100 100 25 100 100 100 100 34 11 18 25 25 34 26 22 22 22 22 22 680 680 680 680 680 680 15 15 15 15 15 15 80 120 120 80 80 80 52 30 25 25 25 25 25 35 19 19 25.35 25.35 35 133.6 133.6 133.6 (133.35) 133.6 (133.35) 133.6 133.6 1 4 (8**) 1 4 (8**) 1 4 (8**) 1 4 (8**) 1 4 (8**) 1 4

150528 E Fette Compacting GmbH Grabauer Strasse 24 21493 Schwarzenbek Germany Phone +49 4151 12-0 Fax +49 4151 3797 tablet@fette-compacting.com Fette Compacting america, inc. 400 Forge Way Rockaway N.J. 07866 USA Phone +1 973 5868722 Fax +1 973 5860450 sales@fetteamerica.com Fette Compacting america Latina Ltda. Av. Cambacica, 1200 módulo 10 Parque Imperador CEP 13097-160 Campinas / SP Brazil Phone/Fax +55 19 37969910 contato@fette-compacting.com.br Fette Compacting Mexico, sa de CV Adolfo Prieto No. 1638 Colonia Del Valle Sur 03100 Mexico, DF Mexico Phone +52 55 4000 0653 tablet@fette-compacting.com Fette (nanjing) Compacting Machinery Co., Ltd. 8 Phoenix Road Jiangning Development Zone 211100 Nanjing China Phone +86 25 52121818 Fax +86 25 52129951 fcn@fette-compacting.com Fette Compacting Machinery india Private Limited Sales Office A-301/302, Citi Point Co-op Society Premises Andheri-Kurla Road, J.B Nagar Andheri East, Mumbai 400 059 Phone +91 22 61220300 sales@fette-compacting.in Competence Centre: Plot No S 115, Phase III B Verna Industrial Estate Verna, Goa 403 722 India Phone +91 832 6690307 Fette Compacting asia Pacific Pte Ltd. 107 Eunos Avenue 3, #01-01 Singapore 409837 Singapore Phone +65 6592 5654 Fax +65 6547 1939 infoasiapacific@fette-compacting.com Fette Compacting ibérica, sl Calle Saturno 1 28760 Tres Cantos Spain Phone +34 91 8039689 Fax +34 91 1730017 fcib@fette-compacting.com ecopac a Fette Compacting and uhlmann Company 1, Rue du Centre 93160 Noisy Le Grand France Phone +33 155 812121 Fax +33 155 812120 ecopac@ecopac.fr www.fette-compacting.com