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1 J Vasc Res 52(2) (2015) print ISSN online e-issn S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney

2 Karger ebook Archive Collection Order before December 31, 2015 and take advantage of our special anniversary discount of 25%. All Karger titles digitized back to 1890 To mark the occasion of Karger Publishers 125th anniversary, all book titles from 1996 back to 1890 have been digitized, making the rich heritage of pioneering Karger publication available to today s medical and scientific community. The complete Karger ebook Archive Collection comprises three individual collections: Series Non-Series German They can be purchased singly or in combination, and encompasses over 2,400 titles, including nearly 700 out of-print titles, as well as numerous books not previously available in electronic format. Complete your existing holdings or make sure your library has access to all Karger medical classics, past and present, with the Karger ebook Archive Collection. For more information, please contact us at: ebooks@karger.com Karger Online Collections Samples of Karger ebook Archive Collection content are available at KI15474

3 Official Journal of the European Society for Microcirculation Founded 1964 as Angiologica by M. Comèl and L. Laszt ( ) continued as Blood Vessels by J.A. Bevan ( ) continued as Journal of Vascular Research by M.J. Mulvany ( ) Incorporating International Journal of Microcirculation, Clinical and Experimental, founded 1980 by the European Society for Microcirculation Editor-in-Chief U. Pohl, Munich Associate Editors J.G.R. de Mey, Maastricht I. Fleming, Frankfurt/Main A. Koller, Budapest/Valhalla, N.Y. (Reviews) G.A. Meininger, Columbia, Mo. E. van Bavel, Amsterdam J.D. Pearson, London M. Ziche, Siena Editorial Assistant E. Aralikatti, Munich Editorial Board J.E. Brayden, Burlington, Vt. G. Breier, Dresden N.J. Brown, Sheffield G. Clough, Southampton M.J. Davis, Columbia, Mo. J.C. Frisbee, Morgantown, W.Va. C.J. Garland, Oxford M. Gassmann, Zürich T. Gloe, Mannheim M. Gollasch, Berlin A.M. Heagerty, Manchester P. Hellstrand, Lund D. Henrion, Angers C. Hill, Canberra M.A. Hill, Columbia, Miss. Y. Huang, Shatin, Hong Kong V.H. Huxley, Columbia, Mo. J.D. Imig, Milwaukee, Wisc. W.F. Jackson, East Lansing, Mich. I. Laher, Vancouver, B.C. T.M. Lincoln, Mobile, Ala. L. Lindbom, Stockholm J. Lopez-Barneo, Sevilla R.M. Lynch, Tucson, Ariz. J.M. Marshall, Birmingham S. Massberg, Boston, Mass. J.C.I. McGrath, Glasgow A.C. Newby, Bristol H. Nilsson, Göteborg M.G.A. oude Egbrink, Maastricht A.R. Pries, Berlin I.H. Sarelius, Rochester, N.Y. E.L. Schiffrin, Montréal, Que. G.W. Schmid-Schönbein, La Jolla, Calif. S.M. Schwartz, Seattle, Wash. S.S. Segal, Columbia, Mo. A.C. Shore, Exeter U. Simonsen, Aarhus L. Sorokin, Muenster D.W. Stepp, Augusta, Ga. A. Tedgui, Paris J.E. Tooke, London V.W. van Hinsbergh, Amsterdam E. Vicaut, Paris U.H. von Andrian, Boston, Mass. B.R. Wamhoff, Charlottesville, Va. C. Webb, Augusta, Ga. C. de Wit, Luebeck Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

4 Guidelines for Authors The Journal of Vascular Research publishes manuscripts of scientific distinction in the vascular, microvascular and lymphatic fields, as regards biology, physiology and pathophysiology, with an emphasis on mechanisms. The scope of the journal covers a broad spectrum of research, including structure, function, hemodynamics, mechanics, pharmacology, cell signalling, intercellular communication, growth and differentiation. Papers employing cellular, biophysical, molecular and intravital microscopic as well as more classical techniques are welcome. Clinical approaches (especially in the field of microcirculation) will be readily considered only if they provide new insights into the origin or rational therapy of diseases. Manuscripts may be in the form of research papers, reviews, short communications, letters to the editor, commentaries and new methods in vascular research. In all cases, the criteria for acceptance are based on completeness, novelty and scientific excellence. Submission Only original papers written in English are considered. Research papers and reviews should not normally be more than 10 printed pages in length including illustrations and references (approximately 6,460 characters, spaces included per printed page). Authors wishing to submit a Review should contact the Editors in advance. Short communications should not exceed 3 printed pages. Manuscripts to the Journal of Vascular Research can now be submitted online! Detailed online submission instructions with a link to the submission website are at Before submitting your manuscript, you are encouraged to review the detailed guidelines at for specific directions as how to get a manuscript ready for submission. Should you have any problems with your submission or feel the need to submit the paper in a non-electronic form, please contact the editorial office: Editorial Office: Eva Aralikatti jvr@karger.com Tel Fax Conditions All manuscripts must be accompanied by a covering letter signed by all authors and are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of the Journal of Vascular Research and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. Sections Research Papers: Submitted manuscripts should be fully documented reports of original research. They must describe significant and original observations which can be critically evaluated and, if necessary, repeated. Review: Reviews concerned with topics of current interest in vascular research will be welcome. Potential authors are asked to contact the editors before submitting their papers in order to avoid clashes with other pending reviews. All reviews will be subjected to normal critical peer refereeing. Methods in Vascular Biology: Primarily methodological papers of interest to the average reader. They should follow the normal arrangement of research papers, including an abstract not exceeding 150 words and should not be more than 3 printed pages in length (including figures, tables and references). Rapid Communication: Manuscripts intended as rapid communications must present new and exciting results of sufficient importance to justify their accelerated acceptance. They should follow the normal arrangement of research papers, including an abstract not exceeding 150 words. Rapid communications should not be more than 3 printed pages in length (including figures, tables and references). Rapid communications can only be accepted as they are or with minor modifications. Rejected manuscripts can only be reconsidered as regular papers. Review will be rapid, and, once accepted, the paper will be included in the next planned issue. Commentary: Comments concerning current topics of interest in vascular science will be considered for publication by the Editors. They should not be more than one printed page in length (approx. 6,460 characters, spaces included). Letter to the Editor: Letters to the Editor concerning articles published in Journal of Vascular Research may be submitted for publication. If accepted, the authors of the articles concerned will be given the opportunity to reply. Arrangement Manuscript organization: Manuscripts should include, in sequence and on separate pages: title and authors, address, running title and acknowledgment of support; abstract and key words; introduction; methods; results; discussion; acknowledgments; references; tables; figures. The normal maximum length is 10 printed pages (including tables, illustrations and references), one printed page containing approximately 6,460 characters, spaces included. Title page: The first page of each paper should indicate the title, the authors names, the institute where the work was conducted, and a short title for use as running head. Full address: The exact postal address of the corresponding author complete with postal code must be given at the bottom of the title page. Please also supply phone and fax numbers, as well as an address. Key words: For indexing purposes, a list of 3 10 key words in English is essential. Consult previous numbers of Journal of Vascular Research for suitable entries. Abstract: Each paper needs an abstract of up to 200 words. Footnotes: Acknowledgment of support is printed as a footnote to the title. Other footnotes should be avoided. Style: All measurements should normally be in SI units. Blood pressure may be given in mm Hg. Use generic names of drugs. Avoid jargon, euphemisms and abbreviations. Tables and illustrations: Tables and illustrations (both numbered in Arabic numerals) should be prepared on separate pages. Tables require a heading and figures a legend, also prepared on a separate page. Due to technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size mm) or provide crop marks. Each illustration must be labelled with its number and the first author s name. b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling (final size), line drawings one of 800 1,200 dpi. Figure files must not be embedded in a document file but submitted separately (see detailed instructions at jvr_guidelines). References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as unpublished data and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals ( Examples (a) Papers published in periodicals: Robinson CM, O Dee D, Hamilton T, Nau GJ: Cytokines involved in interferon-γ production by human macrophages. J Innate Immun 2010;2: (b) Papers published only with DOI numbers: Konstantinou GN, Bousquet PJ, Zuberbier T, Papadopoulos NG: The longest wheal diameter is the optimal measurement for the evaluation of skin prick tests. Int Arch Allergy Immunol DOI: / (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 4, revised. Basel, Karger, (d) Chapters published in edited books: Li L, Boussiotis V: Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences; in Blaser K (ed): T Cell Regulation in Allergy, Asthma and Atopic Skin Diseases. Chem Immunol. Basel, Karger, 2009, vol 94, pp Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists (format setting: Intervirology). Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at Supplementary Material Supplementary material is restricted to additional data that are not necessary for the scientific integrity and conclusions of the paper. Please note that all supplementary files will undergo editorial review and should be submitted together with the original manuscript. The Editors reserve the right to limit the scope and length of the supplementary material. Supplementary material must meet production quality standards for Web publication without the need for any modification or editing. In general, supplementary files should not exceed 10 Mb in size. All figures and tables should have titles and legends and all files should be supplied separately and named clearly. Acceptable files and for S. Karger AG, Basel karger@karger.com The Guidelines for Authors are available at:

5 Guidelines for Authors mats are: Word or PDF files, Excel spreadsheets (only if the data cannot be converted properly to a PDF file), and video files (.mov,.avi,.mpeg). Video Files Video files for the Journal of Vascular Research enhance the online versions. The printed journal remains the archival version. Since it does not contain video files, the latter can only be supplements which improve the reader s understanding of the paper. In the printed version they should be replaced by a typical figure. For further information, please refer to jvr_guidelines. Color Illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF per page. Page Charges Authors are charged CHF per printed page. 1 printed page is equal to approximately 2 manuscript pages (approx. 6,460 characters, spaces included). Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at The option is available for a onetime fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at NIH-Funded Research The U.S. National Institutes of Health (NIH) mandates under the NIH Public Access Policy that final, peer-reviewed manuscripts appear in its digital database within 12 months of the official publication date. As a service to authors, Karger submits the final version of your article on your behalf to PubMed Central. For those selecting our premium Author s Choice TM service, we will send your article immediately upon publishing, accelerating the accessibility of your work without the usual embargo. More details on NIH s Public Access Policy is available at Self-Archiving Karger permits authors to archive their pre-prints (i.e. pre-refereeing) or post-prints (i.e. final draft post-refereeing) on their personal or institution s servers, provided the following conditions are met: Articles may not be used for commercial purposes, must be linked to the publisher s version, and must acknowledge the publisher s copyright. Authors selecting Karger s Author s Choice TM feature, however, are also permitted to archive the final, published version of their article, which includes copyediting and design improvements as well as citation links. Copy Editing All manuscripts accepted for publication by Karger are subject to copy editing. Changes introduced by the copy editor and/or questions will be marked in the manuscript so please be sure to check the galleys against the manuscript. The copy edited manuscript will be returned along with the proofs. Proofs Unless indicated otherwise, proofs are sent to the corresponding author and should be returned with the least possible delay. Alterations made in proofs, other than the correction of printer s errors, are charged to the author. No page proofs are supplied. Reprints Order forms and a price list are sent with the proofs. Orders submitted after the issue is printed are subject to considerably higher prices. No. 74 Published April 2015 Kent R. Anderson New! The Medical Publisher in the Information Age The People behind Our Publications Meet the Editors of Karger s Journals Passion, Persistence, Progress Interviews with Marcel Tanner, Michael Hall, and Susan Gasser Karger Gazette Karger Publishers For over 40 years the Karger Gazette has been distributed to a growing audience worldwide. Published in newspaper format, it highlights advances in biomedicine and clinical practice, introduces personalities, portrays research institutes and chronicles milestones in the history of Karger Publishers in a lively and readable style. The new anniversary issue celebrates Karger s 125 years as a medical publisher. It explores the STM publishing business in the digital age, offers short portraits of Karger s journal and book series editors, and includes interviews with three renowned scientists who talk about their careers and how they define progress. Register for a free print subscription or read it online at S. Karger AG Medical and Scientific Publishers Karger Gazette Allschwilerstrasse 10 CH 4009 Basel Switzerland KI15375

6 General Information ISSN Print Edition: ISSN Online Edition: Journal Homepage: Publication Data: Journal of Vascular Research is published 6 times a year. Volume 52 with 6 issues appears in Copyright: 2015 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Photocopying: This journal has been registered with the Copyright Clearance Center (CCC), as indicated by the code appearing on the first page of each article. For readers in the US, this code signals consent for copying of articles for personal or internal use, or for the personal or internal use of specific clients, provided that the stated fee is paid per copy directly to Copyright Clearance Center Inc. 222 Rosewood Drive Danvers, MA (USA) A copy of the first page of the article must accompany payment. Consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale. In these cases, specific written permission must be obtained from the copyright owner, S. Karger AG, P.O. Box CH 4009 Basel (Switzerland). Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: karger@snet.net France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source. karger@karger.com

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

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10 Karger Publishers 125 Years of Experience in Medical and Scientific Publishing Festschrift Karger Connecting the World of Biomedical Science This richly illustrated Festschrift chronicles the company s development and contributions in the service of medicine and science since It tells the history of Karger Publishers until the present day. Medical and Scientific Publishers Please send an to 125years@karger.com to receive your free copy or discover it online. Publishing Highlights Take a guided tour through 125 years of medical and scientific publishing! Follow us on a leisurely walk through interesting times, fascinating topics and beautiful illustrations. Karger Gazette The Karger Gazette anniversary issue explores the STM publishing business in the digital age, offers short portraits of Karger s journal and book series editors as well as interviews with three renowned scientists. KI15184

11 Research Papers 71 Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through mir-22-mediated ICAM-1 Inhibition Gidlöf, O.; Sathanoori, R. (Lund); Magistri, M.; Faghihi, M.A.; Wahlestedt, C. (Miami, Fla.); Olde, B.; Erlinge, D. (Lund) 81 Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm Charolidi, N.; Pirianov, G.; Torsney, E.; Pearce, S.; Laing, K.; Nohturfft, A.; Cockerill, G.W. (London) 94 Vasopeptidase Inhibition Corrects the Structure and Function of the Small Arteries in Experimental Renal Insufficiency Haltia, O.; Törmänen, S.; Eräranta, A.; Jokihaara, J. (Tampere); Nordhausen, K. (Tampere/Turku); Rysä, J. (Kuopio/Oulu); Ruskoaho, H. (Oulu/Helsinki); Tikkanen, I. (Helsinki); Mustonen, J.; Pörsti, I. (Tampere) 103 Cerebral Artery Remodeling in Rodent Models of Subarachnoid Hemorrhage Guvenc Tuna, B.; Lachkar, N.; de Vos, J.; Bakker, E.N.T.P.; VanBavel, E. (Amsterdam) 116 In vivo Tube Assay: An Optimised Protocol of the Directed in vivo Angiogenesis Assay by Implementing Immunohistochemistry Unseld, M.; Breuss, J.M.; Pausz, C.; Pablik, E.; Schabbauer, G.; Zielinski, C.C.; Uhrin, P.; Prager, G.W. (Vienna) 127 Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall Tanaka, H. (Hamamatsu); Zaima, N. (Hamamatsu/Higashiosaka); Sasaki, T.; Yamamoto, N.; Inuzuka, K.; Sano, M.; Saito, T. (Hamamatsu); Hayasaka, T. (Hamamatsu/Sapporo); Goto-Inoue, N. (Hamamatsu/Tokyo); Sato, K. (Hamamatsu); Kugo, H.; Moriyama, T. (Higashiosaka); Konno, H. (Hamamatsu); Setou, M. (Hamamatsu/Hong Kong); Unno, N. (Hamamatsu) Review 136 Integration and Modulation of Intercellular Signaling Underlying Blood Flow Control Segal, S.S. (Columbia, Mo.) Announcement 158 JVR/ESM Prize 2015 Awarded to Prof. Martin Bennett Pohl, U. (Munich) 115 Erratum 160 Conference Calendar after 160 Membership of the ESM