International Journal of Gastroenterology

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1 Digestion 95(1) (2017) print online ISSN e-issn ISBN International Journal of Gastroenterology JGA Special Issue 2017 Editor Yasuhisa Shinomura, Ikeda Including Abstracts of IGICS: JGA Keynote Program The 9th International Gastrointestinal Consensus Symposium S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney

2 Three BMA awards for Karger Publishers We are delighted to announce that three Karger titles received Highly Commended awards by the British Medical Association in their prestigious 2016 Medical Book Competition: In the category Internal Medicine In the category Oncology Current Problems in Dermatology : P. Itin, G.B.E. Jemec Vol. 48 Tattooed Skin and Health J. Serup N. Kluger W. Bäumler Developments in Ophthalmology Editor: F. Bandello Vol. 55 Retinal Pharmacotherapeutics Quan Dong Nguyen Eduardo B. Rodrigues Michel Eid Farah William F. Mieler Diana V. Do Progress in Tumor Research (formerly Progress in Experimental Tumor Research) : R.A. Stahel, S. Peters Vol. 42 Immuno-Oncology O. Michielin G. Coukos Tattooed Skin and Health : Serup, J. (Copenhagen); Kluger, N. (Helsinki); Bäumler, W. (Regensburg) X p., 110 fig., 85 in color, 25 tab., hard cover, 2015 ISBN e-isbn Retinal Pharmacotherapeutics : Nguyen, Q.D. (Omaha, Nebr.); Rodrigues, E.B. (São Paulo); Farah, M.E. (São Paulo); Mieler, W.F. (Chicago, Ill.); Do, D.V. (Omaha, Nebr.) XVI p., 83 fig., 71 in color, 33 tab., hard cover, 2016 ISBN e-isbn Immuno-Oncology : Michielin, O.; Coukos, G. (Lausanne) VI p., 8 fig., 5 in color, 11 tab., hard cover, 2015 ISBN e-isbn Karger titles which received awards in previous BMA Medical Book Competitions Olszewski and Baxter s Cytoarchitecture of the Human Brainstem J.A. Büttner-Ennever A.K.E. Horn 3rd, revised and extended edition Progress in Respiratory Research Editor: C.T. Bolliger Vol. 38 Paediatric Bronchoscopy K.N. Priftis M.B. Anthracopoulos E. Eber A.C. Koumbourlis R.E. Wood Developments in Ophthalmology : F. Bandello, W. Behrens-Baumann Vol. 47 Macular Edema A Practical Approach Editor Gabriel Coscas Co- José Cunha-Vaz Anat Loewenstein Gisèle Soubrane KI

3 Official Organ of the Society for Dermopharmacy Journal of Pharmacological and Biophysical Research Founded in 1988 by H. Schaefer as Skin Pharmacology Edited by H.F. Merk Skin Pharmacology and Applied Skin Physiology Incorporating Bioengineering and the Skin Editor J. Lademann, Berlin Honorary Editor H.F. Merk, Aachen Associate P.M. Elias, San Francisco, Calif. J.W. Fluhr, Berlin H.I. Maibach, San Francisco, Calif. H. Mukhtar, Madison, Wis. G.J. Nohynek, Asnières M. Roberts, Brisbane, Qld. C. Surber, Basel P.C.M. van de Kerkhof, Nijmegen Editorial Board N. Ahmad, Madison, Wis. C. Antoniou, Athens J.M. Baron, Aachen E. Benfeldt, Roskilde E. Berardesca, Rome K. De Paepe, Brussels P. Elsner, Jena A. Farkas, Zurich N. Garcia Bartels, Berlin M.W. Greaves, London R.H. Guy, Bath S. Hedtrich, Berlin E.M. Jackson, Bonney Lake, Wash. H. Kandárová, Ashland, Mass. L. Kemeny, Szeged J. Kresken, Viersen J. Krutmann, Düsseldorf B. Lange-Asschenfeldt, Klagenfurt am Wörthersee R. Neubert, Halle T. Ruzicka, Munich M. Schäfer-Korting, Berlin M. Schmuth, Innsbruck S. Seidenari, Modena P.W. Wertz, Iowa City, Iowa J. Wohlrab, Halle L. Zastrow, Monaco Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

4 Guidelines for Authors Submission Manuscripts written in English should be submitted using the online submission website: Should you have any problems with your submission, please contact the Editorial Office: Professor Dr. med. J. Lademann Editorial Office Skin Pharmacology and Physiology S. Karger AG PO Box CH 4009 Basel (Switzerland) Tel Fax Conditions All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of Skin Pharmacology and Physiology and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. The journal consists of the following sections: 1. Editorials 2. Reviews 3. Original Papers 4. Short Communications 5. GD Communications Short Communications Authors may apply to have their paper treated as a short communication. Condition for this is a brief definite report of important results. Final decision whether a paper will be published as a short communication will be made by the. A publication time of two months after acceptance is intended. Conflicts of Interest Authors are required to disclose any sponsorship or funding arrangements relating to their research and all authors should disclose any possible conflicts of interest. Conflict of interest statements will be published at the end of the article. Arrangement Title page: The first page of each paper should indicate the title, the authors names, the institute where the work was conducted, and a short title for use as running head. Full address: The exact postal address of the corresponding author complete with postal code must be given at the bottom of the title page. Please also supply phone and fax numbers, as well as address. Key words: Please supply 3 10 key words in English that reflect the content of the paper. Abstract: Each paper needs an abstract in English of not more than 200 words. The abstract is of utmost importance. It should consist of four paragraphs, labeled Background/Aims, Methods, Results and Conclusion, describing briefly the problem addressed by the study, how the study was performed, the salient results, and what the authors conclude from the results. Footnotes: Avoid footnotes. Tables and illustrations: Tables and illustrations (both numbered in Arabic numerals) should be sent in separate files. Tables require a heading and figures a legend, also in a separate file. Due to technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size mm). Black and white half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800 1,200 dpi. Color illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF per page. References: In the text, identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal : Uniform requirements for manuscripts submitted to biomedical journals ( Examples: (a) Papers published in periodicals: Chatel J-M, Bernard H, Orson FM: Isolation and characterization of two complete Ara h 2 isoforms cdna. Int Arch Allergy Immunol 2003;131: (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: / (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, (d) Edited books: DuBois RN: Cyclooxygenase-2 and colorectal cancer; in Dannenberg AJ, Dubois RN (eds): COX-2. Prog Exp Tum Res. Basel, Karger, 2003, vol 37, pp Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists. Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at Supplementary Material Multimedia files and other supplementary files, directly relevant but not essential to the conclusions of a paper, enhance the online version of a publication and increase its visibility on the web. These files will undergo editorial review. The reserve the right to limit the scope and length of the supplementary material. Multimedia and supplementary material should meet production quality standards for publication without the need for any modification or editing. Files should not exceed 10 MB in size. Figures and tables need to have titles and legends, and all files should be supplied separately and labeled clearly. All supplementary material should be referred to in the main text. A DOI number will be assigned to supplementary material and it will be hosted online at under a CC BY license. Authors will be charged a processing fee of CHF for supplementary material. Self-Archiving/Green Open Access Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following publication of the final version of their article. 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Karger AG, Basel karger@karger.com The Guidelines for Authors are available at:

5 : J. Ring, K. Blaser, M. Capron, J.A. Denburg, S.T. Holgate, G. Marone, H. Saito Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at The option is available for a onetime fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at The final, published version of the article may be posted at any time and in any repository or on other websites, in accordance with the relevant Creative Commons license. Reposted Open Access articles must: Follow the terms of the relevant Creative Commons license Be linked to the final version on Include the following statement: The final, published version of this article is available at DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Funding Organizations (NIH etc.) The U.S. National Institutes of Health (NIH) Public Access Policy mandates that accepted, peer-reviewed manuscripts are archived in its digital database, PubMed Central (PMC), within 12 months of the official publication date. As a service to authors, Karger submits NIH-funded articles to PMC on behalf of the authors immediately upon publication. The NIH assigns a PMCID within approximately 1 month and the manuscript will appear in PMC after a 12-month embargo. For authors making their paper Open Access through Author s Choice TM, the embargo will be overridden, thereby accelerating the accessibility of the article. Karger also complies with other funders requirements (including Wellcome Trust and RCUK) for submission to PMC. Authors should include information on their grants in the Acknowledgements section of their papers. Page Charges There are no page charges for papers of 5 or fewer printed pages (including tables, illustrations and references). Each additional complete or partial page is charged to the author at CHF The allotted size of a paper is equivalent to approximately 15 double-spaced manuscript pages (including abstract, tables, illustrations and references). Proofs Unless indicated otherwise, proofs are sent to the corresponding author and should be returned with the least possible delay. Alterations other than the correction of printer s errors are charged to the author. Reprints Order forms and a price list are sent with the proofs. Orders submitted after the issue is printed are subject to considerably higher prices. Read it online: Chemical Immunology and Allergy... There can be few immunologists in a position to ignore the help provided by these timely reviews... essential reading for virtually all immunologists. Immunology Appearing for the first time in 1939, Progress in Allergy was the first and, for many years, the only international review series in the English language devoted to immunology. The present title, Chemical Immunology and Allergy, reflects the rapidly increasing role of concepts and techniques of molecular and cell biology, as well as the greater emphasis now being placed on research into the biologic problems of immunology, hypersensitivity and immunopathology. Highly specialized, single-topic volumes keep both investigators and practicing physicians up to date with the latest developments in areas of immunology and allergy where recent research has been concentrated. Chemical Immunology and Allergy Vol. 101 Food Allergy: Molecular Basis and Clinical Practice M. Ebisawa B.K. Ballmer-Weber S. Vieths R.A. Wood Chemical Immunology and Allergy Founded: 1939 Fields of Interest: Immunology, Allergy Listed in bibliographic services, including: PubMed/MEDLINE, Google Scholar ISSN e-issn Vol. 101: Food Allergy: Molecular Basis and Clinical Practice : Ebisawa, M. (Sagamihara); Ballmer-Weber, B.K. (Zurich); Vieths, S. (Langen); Wood, R.A. (Baltimore, Md.) XVI p., 19 fig., 4 in color, 56 tab., 2015 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 100: History of Allergy : Bergmann, K.-C. (Berlin); Ring, J. (Munich) X p., 257 fig., 127 in color, 20 tab., 2014 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn Vol. 99: Angiogenesis, Lymphangiogenesis and Clinical Implications : Marone, G.; Granata, F. (Naples) XII p., 26 fig., 14 in color, 8 tab., 2014 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn *online prices for personal customer **online prices for institutional purchase Prices subject to change, VAT not included. EUR price for eurozone countries, USD price for USA and Latin America only Vol. 98: Allergy and the Nervous System Editor: Bienenstock, J. (Hamilton, Ont.) XII p., 51 fig., 4 tab., 2012 CHF / EUR / USD (hardcover or online*) CHF / EUR / USD (online**) ISBN e-isbn this book is quite unique in this field, by providing a comprehensive and up-dated review of all major research and clinical issues for both experts in this area and those who wish to discover the fascinating world of body-mind interactions in allergy and asthma. Sergio Bonini, Website of the EAACI KI S. Karger AG, Basel karger@karger.com The Guidelines for Authors are available at:

6 General Information ISSN Print Edition: ISSN Online Edition: Journal Homepage: Publication Data: Skin Pharmacology and Physiology is published 6 times a year. Volume 29 with 6 issues appears in Copyright: 2016 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Please enquire about reduced rates for members of related societies. Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Photocopying: This journal has been registered with the Copyright Clearance Center (CCC), as indicated by the code appearing on the first page of each article. For readers in the US, this code signals consent for copying of articles for personal or internal use, or for the personal or internal use of specific clients, provided that the stated fee is paid per copy directly to Copyright Clearance Center Inc. 222 Rosewood Drive Danvers, MA (USA) A copy of the first page of the article must accompany payment. Consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale. In these cases, specific written permission must be obtained from the copyright owner, S. Karger AG, P.O. Box CH 4009 Basel (Switzerland). Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: kargerusa@karger.com France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source S. Karger AG, Basel karger@karger.com The Journal Home Page is available at:

7 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

8 ESTABLISHED AND CONTINUOUSLY PUBLISHED SINCE Focussing on clinical research reports ESTABLISHED 1895 AN D I G E S TION UBLISHED I O N SINCE International Journal of Gastroenterology -in-chief V. Ellenrieder, Göttingen K. Higuchi, Osaka Established and continuously published since 1895 Official Organ of The Japanese Gastroenterological Association (JGA) Digestion concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/ Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology. Digestion Founded: 1895 Category: Clinical Research Field of Interest: Gastroenterology Listed in bibliographic services, including: PubMed/MEDLINE, Web of Science, Google Scholar, Scopus, Embase 2017: Volumes 95, 96 4 issues per volume Language: English ISSN e-issn Impact Factor: Selected contributions NSAID-Induced Small Intestinal Damage Roles of Various Pathogenic Factors: Takeuchi, K. (Misasagi/Kyoto); Satoh, H. (Kyoto/Kyotanabe) Established and Potential Predictive Biomarkers in Gastrointestinal Cancer c-kit, Her2, Ras and Beyond: Koch, C.; Trojan, J. (Frankfurt am Main) Evaluation of the Expanded Criteria of Endoscopic Submucosal Dissection for Early Gastric Cancers: A Meta-Analysis: Dai, J.; Huang, X.; Lu, B.; Jin, H.; Meng, L. (Hangzhou) Combination Therapy with Infliximab and Thiopurine Compared to Infliximab Monotherapy in Maintaining Remission of Postoperative Crohn s Disease: Sakuraba, A. (Tokyo/Chicago, Ill.); Okamoto, S.; Matsuoka, K.; Sato, T.; Naganuma, M.; Hisamatsu, T.; Iwao, Y.; Ogata, H.; Kanai, T.; Hibi, T. (Tokyo) Decreased Risk of Colorectal Cancer after Colonoscopy in Patients Years Old in the United States: Wang, Y.R. (Camden, N.J.); Cangemi, J.R. (Jacksonville, Fla.); Loftus, E.V., Jr. (Rochester, Minn.); Picco, M.F. (Jacksonville, Fla.) Unnecessary Procedures and Surgery in Autoimmune Pancreatitis: Manser, C.N.; Gubler, C.; Müllhaupt, B.; Bauerfeind, P. (Zurich) New Advances in the Treatment of Metastatic Pancreatic Cancer: Schober, M. (Halle); Javed, M.A. (Liverpool); Beyer, G. (Greifswald); Le, N. (Budapest); Vinci, A. (Pavia); Sund, M. (Umea); Neesse, A. (Göttingen); Krug, S. (Halle) Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis: Zhang, F.-M.; Chen, L.-H.; Chen, H.-T.; Shan, G.-D.; Hu, F.-L.; Yang, M.; Chen, W.-G.; Xu, G.-Q. (Hangzhou) More information at KF17032

9 JGA Special Issue 2017 Editor Yasuhisa Shinomura, Ikeda Including Abstracts of IGICS: JGA Keynote Program The 9th International Gastrointestinal Consensus Symposium

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