online e-issn print ISSN X J Innate Immun 8(4) (2016)

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1 S. Karger Medical and Scientific Publishers Basel. Freiburg. Paris. London. New York. Chennai. New Delhi. Bangkok. Beijing. Shanghai. Tokyo. Kuala Lumpur. Singapore. Sydney print ISSN X online e-issn J Innate Immun 8(4) (2016)

2 A treasure trove of fascinating and richly illustrated information Chemical Immunology and Allergy Editors: J. Ring, K. Blaser, M. Capron, J.A. Denburg, S.T. Holgate, G. Marone, H. Saito Vol. 100 History of Allergy Editors K.-C. Bergmann J. Ring History of Allergy Editors Karl-Christian Bergmann Johannes Ring History of Allergy Editors: Bergmann, K.-C. (Berlin); Ring, J. (Munich) XX p., 257 fig., 127 in color, 20 tab., 2014 CHF / EUR / USD (hard cover) CHF / EUR / USD (online) Online version for institutional purchase, prices subject to change EUR price for Germany, USD price for USA and Latin America only ISBN (hard cover) e-isbn Chemical Immunology and Allergy, Vol. 100 Series Editors: Ring, J. (Munich); Blaser, K. (Davos); Capron, M. (Lille); Denburg, J.A. (Hamilton, Ont.); Holgate, S.T. (Southampton); Marone, G. (Napoli); Saito, H. (Tokyo) Listed in MEDLINE/PubMed Dear Librarian I have reviewed this publication and would like to recommend it for our library. Recommended by: Department: Date: This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights into allergy from antiquity to the 20th century, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading. Contents Allergy through 20 Centuries History of Allergy in Antiquity: Ring, J. History of Allergy in the Middle Ages and Renaissance: Ring, J. Landmarks in Allergy during the 19th Century: Kay, A.B. Milestones in the 20th Century: Bergmann, K.-C. Terminology of Allergic Phenomena: Ring, J. Most Common Allergic Diseases: Historical Reflections in Understanding Anaphylaxis: Ring, J. et al. Allergic Rhinitis: Mygind, N. Asthma: Bergmann, K.-C. Atopic Dermatitis/Atopic Eczema: Wallach, D.; Taïeb, A. Allergic Contact Dermatitis: Alikhan, A.; Maibach H.I. Urticaria and Angioedema: Maurer, M. Allergy and the Eye: Bonini, S. History of Food Allergy: Wüthrich, B. Drug Hypersensitivity: Bircher, A.J. Aspirin Hypersensitivity: Sánchez-Borges, M. Bradykinin-Mediated Disease: Kaplan, A.P. Mechanisms of Allergy: Important Discoveries The Discovery of Immunoglobulin E and Its Role in Allergy: Johansson, S.G.O. T Cell Subpopulations: Romagnani, S. Mast Cell Research: Saito, H. Basophils: Historical Reflections and Perspectives: Marone, G. et al. Eosinophils: Radonjic-Hösli, S.; Simon, H.-U. The Bradykinin-Forming Cascade: A Historical Perspective: Kaplan, A.P. Histamine Receptors and Antihistamines: From Discovery to Clinical Applications: Cataldi, M. et al. Detection of Environmental Influences and Allergens Pollen and Pollinosis: Smith, M. et al. Mites and Allergy: Fernández-Caldas, E. et al. Mammalian Airborne Allergens: Aalberse, R.C. The Latex Story: Raulf, M. Peanut Allergens: Becker, W.-M.; Jappe, U. Environmental Pollution and Allergy: Historical Aspects: Behrendt, H. et al. Farmers and Their Environment: Protective Influences of the Farming Environment against the Development of Allergies: Gassner, M. Progress in Allergy Management History of Catecholamine Research: Starke, K. Antihistamines: Church, M.K.; Maurer, M. Glucocorticoids: Barnes, P.J. Chromones: Edwards, A.M. Characterization and Standardization of Allergen Extracts: Løwenstein, H. Allergen-Specific Immunotherapy: Nelson, H.S.; Norman, P.S. Pioneers of Allergy: Personal Reflections K. Frank Austen John Bienenstock Kurt Blaser Alain de Weck ( ) Alfred William Frankland Oscar L. Frick Kimishige Ishizaka Lothar Jäger Terumasa Miyamoto Harry Morrow Brown ( ) Albert K. Oehling Heimo Reulecke Václav Špičák Allergy Societies and Collections AAAAI APAAACI CIA EAACI JSA SLAAI WAO AAAAI Archives The Ilya Mechnikov Collection in Riga Online Supplementary Material Movie 1: Anaphylaxie et Allergie Movie 2: World Allergy: The Disease of Civilization List of Illustrations / Figure Credits Subject Index Signature: Orders may be placed with any bookshop, subscription agency, directly with the publisher or through a Karger distributor. KI14231 The easiest way to order: Karger Medical and Scientific Publishers CH 4009 Basel, Switzerland orders@karger.com, f:

3 Contents See the journal website for contents Basel Freiburg Paris London New York New Delhi Bangkok Beijing Tokyo Kuala Lumpur Singapore Sydney

4 Editors-in-Chief H. Herwald, Lund A. Egesten, Lund Editorial Board B. Beutler, Dallas, Tex. V. Brinkmann, Berlin G.D. Brown, Aberdeen B. Dahlbäck, Malmö F.R. DeLeo, Hamilton, Mont. B. Engelmann, Munich J. Harder, Kiel D. Hartl, Tübingen J. Hoffmann, Strasbourg M. Holub, Prague M. Hornef, Hannover T. Kaisho, Yokohama City J.D. Lambeth, Atlanta, Ga. G. McFadden, Gainsville, Fla. E. Medina, Braunschweig A. Mowat, Glasgow P.M. Murphy, Bethesda, Md. V. Nizet, La Jolla, Calif. J.E. Pease, London J. Potempa, Krakow A.S. Prince, New York, N.Y. C.S. Reiss, New York, N.Y. J.A. Russell, Vancouver, B.C. D. Schneider, Stanford, Calif. J.-M. Schröder, Kiel T. Seya, Sapporo O. Soehnlein, Munich C. Speth, Innsbruck U. Theopold, Stockholm J.A.G. van Strijp, Utrecht M.A. Williams, Bethesda, Md. V. Witko Sarsat, Paris M.A. Zasloff, Washington, D.C. Printed in Germany on acid-free and non-aging paper (ISO 9706) by Stückle Druck, Ettenheim

5 Journal of Innate Immunity Guidelines for Authors The Journal of Innate Immunity is a bimonthly published journal that aims to cover all aspects within the area of innate immunity, including evolutionary aspects, pathogen-host cell molecular interactions, host response and inflammation, complement and coagulation, microbial corruption of innate immunity, molecular genomics, development of vaccines and immune therapies. The journal features original papers (Research Articles, Clinical Investigations), Reviews/ Mini Reviews, Letters to the Editors, Rapid Communications and Short Communications. Criteria for acceptance are quality, originality, and clarity. The Journal of Innate Immunity will not consider papers that are either preliminary or purely descriptive. Reports on clinical cases are accepted only if they provide novel insight into unresolved problems of innate immunity. Submission Only original papers written in English are considered. Manuscripts should be submitted online using the online submission website at jin (the preferred word-processing package is MS- Word ). Editorial Office: Heiko Herwald, PhD S. Karger AG Editorial Office Journal of Innate Immunity P.O. Box CH 4009 Basel (Switzerland) Tel Fax jin@karger.com Conditions All manuscripts must be accompanied by a covering letter signed on behalf of all authors. Assurance should be given that the manuscript is not under simultaneous consideration by any other publication. Presentation of manuscripts should conform with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see N Engl J Med 1997;336: ). All manuscripts are subject to editorial review. Submission of an article for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of the Journal of Innate Immunity and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the authors responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications. Sections In addition to regular papers, every issue of the journal will have a special section with a thematic focus. Contributions to these special topic sections are very welcome and authors are asked to contact the Editorsin-Chief or the responsible guest editors before submitting a manuscript in order to avoid clashes with other pending papers. For details see the journal content at All articles will undergo an in-depth peer-review process. Original Paper (Research Article/Clinical Investigation): Submitted manuscripts should be fully documented reports of original research. They must describe significant and original observations. Review: The normal maximum length of a Review is limited to 5 7 printed pages, i.e. approximately 20 manuscript pages (font 12, double spacing), including 1 3 figures and/or tables. The number of references should not exceed 50. Potential authors are asked to contact the editors before submitting their papers in order to avoid clashes with other pending reviews. Letter to the Editor: Letters to the Editor concerning articles published in Journal of Innate Immunity may be submitted for publication. They should not be more than one printed page in length. If accepted, the authors of the articles concerned will be given the opportunity to reply. Arrangement Title page: The first page of each paper should indicate the title, the authors names, the institute(s) where the work was conducted, and a short title for use as running head. Full address: The exact postal address of the corresponding author complete with postal code must be given at the bottom of the title page. Please also supply phone and fax numbers, as well as an address. Key words: For indexing purposes, a list of 3 10 key words in English is essential. Abstract: Each paper needs an abstract of up to 200 words describing background, methods, results and conclusions. Footnotes: Footnotes should be avoided. When essential, they are numbered consecutively and typed at the foot of the appropriate page. Tables and illustrations: Tables and illustrations (both numbered in Arabic numerals) should be prepared on separate pages. Tables require a heading and figures a legend, also prepared on a separate page. Due to technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size mm) or provide crop marks. Each illustration must be labelled with its number and the first author s name. Electronically submitted b/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling (final size), line art drawings one of 800 1,200 dpi. Figure files should not be embedded in a document file but submitted separately. References: In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as [unpublished data] and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Preferably, please cite all authors. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals ( Authors using EndNote may choose the format setting for Intervirology for the correct format of references. Examples (a) Papers published in periodicals: Vilhelmsson M, Johansson C, Jacobsson-Ekman G, Crameri R, Zargari A, Scheynius A: The malassezia sympodialis allergen Mala s 11 induces human dendritic cell maturation, in contrast to its human homologue manganese superoxide dismutase. Int Arch Allergy Immunol 2007;143: (b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: / (c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 4, revised. Basel, Karger, (d) Edited books: Park BK, Sanderson JP, Naisbitt DJ: Drugs as haptens, antigens, and immunogens; in Pichler WJ (ed): Drug Hypersensitivity. Basel, Karger, 2007, pp Ethics Published research must comply with the guidelines for human studies and animal welfare regulations. Authors should state that subjects have given their informed consent and that the study protocol has been approved by the institute s committee on human research and thus meets the standards of the Declaration of Helsinki in its revised version of 1975 and its amendments of 1983, 1989, and 1996 [JAMA 1997;277: ]. Information suitable to reveal the subject s identity is to be avoided. Further, they should also state that animal experiments conform to institutional standards. Copies of these guidelines and policy statements must be available for review by the editors if necessary. Conflict of Interest All forms of funding and support, including that from companies, and any potential competing financial interests should be acknowledged in the cover letter to the editor when applicable. The statement has to be listed at the end of the article. Page Charges There are no page charges for 5 or fewer printed pages, which is equal to approx. 14 manuscript pages including references, figures and tables. Each additional complete or partial printed page is charged to the authors at CHF Digital Object Identifier (DOI) S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at karger@karger.com S. Karger AG, Basel The Guidelines for Authors are available at:

6 Supplementary Material Supplementary material is restricted to additional data that are not necessary for the scientific integrity and conclusions of the paper. Please note that all supplementary files will undergo editorial review and should be submitted together with the original manuscript. The Editors reserve the right to limit the scope and length of the supplementary material. Supplementary material must meet production quality standards for Web publication without the need for any modification or editing. In general, supplementary files should not exceed 10 Mb in size. All figures and tables should have titles and legends and all files should be supplied separately and named clearly. Acceptable files and formats are: Word or PDF files, Excel spreadsheets (only if the data cannot be converted properly to a PDF file), and video files (.mov,.avi,.mpeg). Self-Archiving/Green Open Access Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following publication of the final version of their article. For all self-archiving, the posted manuscripts must: Be used for noncommercial purposes only Be linked to the final version on Include the following statement: This is the peer-reviewed but unedited manuscript version of the following article: [insert full citation, e.g. Cytogenet Genome Res 2014;142: (DOI: / )]. The final, published version is available at com/?doi=[insert DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Manuscripts to be archived in PubMed Central due to funding requirements will be submitted by Karger on the author s behalf [see Funding Organizations (NIH etc.)]. For self-archiving Author s Choice TM (Gold Open Access) articles, see Author s Choice TM. Author s Choice TM Karger s Author s Choice TM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at The option is available for a onetime fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at The final, published version of the article may be posted at any time and in any repository or on other websites, in accordance with the relevant Creative Commons license. Reposted Open Access articles must: Follow the terms of the relevant Creative Commons license Be linked to the final version on Include the following statement: The final, published version of this article is available at DOI number]. It is the author s responsibility to fulfill these requirements. For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. Funding Organizations (NIH etc.) The U.S. National Institutes of Health (NIH) Public Access Policy mandates that accepted, peer-reviewed manuscripts are archived in its digital database, PubMed Central (PMC), within 12 months of the official publication date. As a service to authors, Karger submits NIH-funded articles to PMC on behalf of the authors immediately upon publication. The NIH assigns a PMCID within approximately 1 month and the manuscript will appear in PMC after a 12-month embargo. For authors making their paper Open Access through Author s Choice TM, the embargo will be overridden, thereby accelerating the accessibility of the article. Karger also complies with other funders requirements (including Wellcome Trust and RCUK) for submission to PMC. Authors should include information on their grants in the Acknowledgements section of their papers. Color Illustrations Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends. Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF per page. Video Files Video files for the Journal of Innate Immunity enhance the online versions. The printed journal remains the archival version. 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7 Journal of Innate Immunity General Information ISSN Print Edition: X ISSN Online Edition: Journal Homepage: Publication Data: Journal of Innate Immunity is published 6 times a year. Volume 8 with 6 issues appears in Copyright: 2016 S. Karger AG, Basel (Switzerland). All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subscription Rates: Subscriptions run for a full calendar year. Prices are given per year. Personal subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Institutional subscription: Print or Online Print+Online combined CHF CHF EUR EUR USD USD postage and handling (added to print and print+online) CHF Europe, CHF Overseas EUR USD Back Volumes and Single Issues: Information on availability and prices of single print issues and print or electronic back volumes can be obtained from Customer Service at service@karger.com. Bibliographic Indices: This journal is regularly listed in bibliographic services, including Current Contents and PubMed/MEDLINE. Photocopying: This journal has been registered with the Copyright Clearance Center (CCC), as indicated by the code appearing on the first page of each article. For readers in the US, this code signals consent for copying of articles for personal or internal use, or for the personal or internal use of specific clients, provided that the stated fee is paid per copy directly to Copyright Clearance Center Inc. 222 Rosewood Drive Danvers, MA (USA) A copy of the first page of the article must accompany payment. Consent does not extend to copying for general distribution, for promotion, for creating new works, or for resale. In these cases, specific written permission must be obtained from the copyright owner, S. Karger AG, P.O. Box CH 4009 Basel (Switzerland). Subscription Orders: Orders can be placed at agencies, bookstores, directly with the Publisher S. Karger AG Medical and Scientific Publishers Allschwilerstrasse 10 CH 4009 Basel Switzerland t: f: e: karger@karger.com w: (for courier services only: Allschwilerstrasse 10 CH 4055 Basel) or further Karger offices or representatives: Germany S. Karger GmbH Postfach Freiburg Deutschland (Hausadresse: Wilhelmstrasse 20A, Freiburg) t: f: e: information@karger.de w: Japan Karger Japan, Inc. Shiba Daimon Asahi Bldg. 2F Shiba Daimon Minato-ku Tokyo Japan t: f: e: publisher@karger.jp w: USA S. Karger Publishers, Inc. 26 West Avon Road P.O. Box 529 Unionville, CT USA Toll free: t: f: e: kargerusa@karger.com France Enter & Read Albertine Luginbuhl 23, rue du Départ, boite Paris France t: +33 (0) e: albertineluginbuhl@orange.fr South East Asia, China and Taiwan Karger Regional Office (Malaysia) Level A, PJ Exchange No. 16A, Persiaran Barat Petaling Jaya Selangor Darul Ehsan Malaysia t: f: e: service@karger.cn; r.chew@karger.cn Karger China 51F Raffles City Centre 268 Xi Zang Middle Road Huang Pu District Shanghai P.R. China t: f: e: service@karger.cn r.chew@karger.cn w: India, Bangladesh, Sri Lanka Karger India Plot No. 17, Yusuf Sarai Market B.L. Glass Building, 2nd Floor Sri Aurobindo Marg New Delhi India t: f: c: e: r.kumar@kargerindia.com w: Change of Address: Both old and new address should be sent to the subscription source. karger@karger.com S. Karger AG, Basel The Journal Home Page is available at:

8 Annual Meeting German Society for Immunology (DGfI) September 2016 z 20=8,9D Important Deadlines Abstract submission: 23 May L]WdMT]O ]PRT^_]L_TZY% 5`YP! Plenary Sessions z 4XX`YZWZRd ZQ 4YQPN_TZY z,`_ztxx`yt_d z =PR`WL_TZY ZQ _SP 4XX`YP =P^[ZY^P l Scirocco340 l shutterstock.com F th

9 17 th annual October, 2016 Fairmont Rey Juan Carlos Barcelona, Spain Research, development and strategic partnering for the global vaccine industry Co-located with Created by Part of See the full programme at F16301

10 International Meeting on Emerging Diseases and Surveillance For further information contact: Downloaded F16278 by:

11 3rd Meeting of Middle-European Societies for Immunology and Allergology MESIA 2016, Budapest, Hungary December 1 st 3 rd 2016 VENUE Danubius Health Spa Resort Margitsziget PRESIDENT OF THE ORGANIZING COMMITTEE Prof Margit Zeher MAIN TOPICS INCLUDE: Innate immunity Adaptive immunity Clinical immunology Autoimmune diseases Biological therapy Tumour immunology Mucosal and barrier immunology Vaccines & Immunotherapy Laboratory diagnostic Allergology Asthma WEBSITE CONTACT WECO Travel Ltd., Congress Department T: E: mesiaconference@wecotravel.hu F16281

12 Experience and progress a unique and accurate outlook on skin diseases Editor-in-Chief G.B.E. Jemec, Roskilde Official Organ of the Swiss Society for Dermatology and Venereology Schweizerische Gesellschaft für Dermatologie und Venerologie Société Suisse de Dermatologie et Vénéréologie European Society of Tattoo and Pigment Research (ESTP) Published since 1893, Dermatology provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to Dermatology. Dermatology answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation. Dermatology Founded: 1893 Category: Clinical Research Field of Interest: Dermatology Listed in bibliographic services, including Journal Citation Reports, PubMed/MEDLINE, Biological Abstracts, Embase, Amedeo 2016: Volume issues per volume Language: English ISSN e-issn Impact Factor: Selected contributions Dermatitis: Nahm, D.-H.; Kim, M.-E.; Cho, S.-M. (Suwon) Pathogenesis and Classification: Drago, F.; Javor, S.; Ciccarese, G.; Cozzani, E.; Parodi, A. (Genoa) Flushing of Rosacea: Park, K.Y.; Hyun, M.Y.; Jeong, S.Y.; Kim, B.J.; Kim, M.N.; Hong, C.K. (Seoul) van der Geer, S. (Venray/Eindhoven); Kleingeld, P.A.M.; Snijders, C.C.P.; Rinkens, F.J.C.H.; Jansen, G.A.E. (Eindhoven); Neumann, H.A.M. (Rotterdam); Krekels G.A.M. (Venray/Eindhoven) Scanners: Mayer, J.E. (New York, N.Y.); Adams, B.B. (Cincinnati, Ohio) Teraki, Y.; Inoue, Y. Dalimier, E. (Paris); Salomon, D. (Geneva) Augustin, M.; Holland, B.; Dartsch, D.; Langenbruch, A.; Radtke, M.A. KIT Imatinib Therapy Case Report and Review of the Literature: Satzger, I.; Küttler, U.; Völker, B.; Schenck, F.; Kapp, A.; Gutzmer, R. More information at

13 Editorial 327 From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis Witko-Sarsat, V. (Paris) Review 330 Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis Meijer, L. (Roscoff); Nelson, D.J.; Riazanski, V.; Gabdoulkhakova, A.G. (Chicago, Ill.); Hery-Arnaud, G.; Le Berre, R. (Brest); Loaëc, N.; Oumata, N. (Roscoff); Galons, H. (Paris); Nowak, E. (Brest); Gueganton, L. (Roscoff); Dorothée, G. (Paris); Prochazkova, M.; Hall, B.; Kulkarni, A.B. (Bethesda, Md.); Gray, R.D.; Rossi, A.G. (Edinburgh); Witko-Sarsat, V. (Paris); Norez, C.; Becq, F. (Poitiers); Ravel, D. (Paris); Mottier, D. (Brest); Rault, G. (Roscoff) Research Articles 374 Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C + Natural Killer Cells Djaoud, Z.; Riou, R.; Gavlovsky, P.-J.; Mehlal, S.; Bressollette, C.; Gérard, N. (Nantes); Gagne, K. (Nantes/Strasbourg); Charreau, B.; Retière, C. (Nantes) 386 Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NFκB-Dependent Mechanism McKenna, S.; Eckman, M.; Parker, A.; Bok, R.; Hurt, K.J.; Wright, C.J. (Aurora, Colo.) 400 Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome Ramos, M.V.; Mejias, M.P.; Sabbione, F.; Fernandez-Brando, R.J. (Buenos Aires); Santiago, A.P. (San Justo); Amaral, M.M. (Buenos Aires); Exeni, R. (San Justo); Trevani, A.S.; Palermo, M.S. (Buenos Aires) 412 The POU/Oct Transcription Factor Pdm1/nub Is Necessary for a Beneficial Gut Microbiota and Normal Lifespan of Drosophila Dantoft, W. (Stockholm); Lundin, D. (Solna/Kalmar); Esfahani, S.S.; Engström, Y. (Stockholm) 350 The Human Glycoprotein Salivary Agglutinin Inhibits the Interaction of DC-SIGN and Langerin with Oral Micro-Organisms Boks, M.A.; Gunput, S.T.G.; Kosten, I.; Gibbs, S.; van Vliet, S.J.; Ligtenberg, A.J.M.; van Kooyk, Y. (Amsterdam) 362 CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense Carevic, M.; Öz, H.; Fuchs, K.; Laval, J.; Schroth, C.; Frey, N.; Hector, A.; Bilich, T.; Haug, M.; Schmidt, A.; Autenrieth, S.E.; Bucher, K.; Beer-Hammer, S. (Tübingen); Gaggar, A. (Birmingham, Ala.); Kneilling, M. (Tübingen); Benarafa, C. (Bern); Gao, J.L.; Murphy, P.M. (Bethesda, Md.); Schwarz, S. (Tübingen); Moepps, B. (Ulm); Hartl, D. (Tübingen) Cover illustration Marthasterias glacialis starfish (Echinoderms), collected in Finistère, Brittany, France. Photo courtesy of Laurent Meijer, Roscoff, France.