Variant List OncoFOCUS v3 Panel
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- Barnaby Gaines
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1 Variant List OncoFOCUS v3 Panel ONCOLOGY c.1405_1406gg>tc p.g469s 458 c.1405g>a p.g469r 457 c.1405_1407gga>agc p.g469s 1113 c.1405_1407gga>agt p.g469s c.1405g>c p.g469r 455 c.1406g>a p.g469e 461 c.1406g>c p.g469a 460 c.1406g>t p.g469v 459 c.1781a>g p.d594g 467 c.1781a>t p.d594v 466 c.1789_1790ct>tc p.l597s 1126 c.1789c>g p.l597v 470 c.1790t>a p.l597q 1125 BRAF c.1790t>g p.l597r 471 c.1798g>t p.v600l c.1798g>a p.v600m 1130 c.1798_1799gt>aa p.v600k 473 c.1798_1799gt>ag p.v600r 474 c.1798g>c p.v600l c.1799_1800tg>aa p.v600e 475 c.1799_1800tg>at p.v600d 477 c.1799t>a p.v600e 476 c.1799t>g p.v600g 6137 c.1801_1803delaaa p.k601del c.1801a>g p.k601e 478 c.1801a>c p.k601q NA c.1803a>c/t p.k601n 1132/6265 c.1803a>g p.k601k c.1793g>t p.g598v c.2155g>t p.g719c 6253 c.2156g>a p.g719d c.2156g>c p.g719a 6239 c.2233_2247del15 p.k745_e749delkelre c.2234_2236delagg/2232_2233ins(18) AAAATTCCCGTCGCTATC p.e746del/i744_k745inskipvai c.2235_2246del(12)ggaattaagaga p.e746_e749del NA NA
2 Variant List OncoFOCUS v3 Panel (PAGE 2 OF 8) c.2235_2246del12/c.2235_2248>aattc/ c.2235_2249del15/c.2235_2251>aattc/c.2235_2251>ag/ c.2235_2252>aat/c.2235_2252del18/c.2235_2255>aat p.e746_e749delelre/p. E746_A750>IP/p.E746_ A750delELREA/p.E746_ T751>IP/p.E746_T751>A/p. E746_T751>I/p.E746_ T751delELREAT/p.E746_S752>I 28517/13550/ 6223/13552/ 13549/13551/ 24869/12385 c.2235_2248>aattc p.e746_a750>ip c.2235_2248>aattc/c.2236_2248>agac/ c.2236_2248>caac/c.2238_2248>gc/ c.2239_2248ttaagagaag>c p.e746_a750>ip/p.e746_ A750>RP/p.E746_A750>QP/p. L747_A750>P/p.L747_A750>P 13550/12413/ 13557/12422/ c.2235_2249del15 p.e746_a750delelrea 6223 c.2235_2251>aattc p.e746_t751>ip c.2235_2251>ag p.e746_t751>a c.2235_2252>aat p.e746_t751>i c.2235_2252del18 p.e746_t751delelreat c.2235_2255>aat p.e746_s752>i c.2236_2248>caac p.e746_a750>qp c.2236_2250del15 p.e746_a750delelrea 6225 c.2236_2251>t p.e746_t751>s c.2236_2252>at p.e746_t751>i c.2236_2253>attcct p.e746_t751>ip c.2236_2253>caa p.e746_t751>q c.2236_2253>cta p.e746_t751>l c.2236_2253del18 p.e746_t751delelreat c.2236_2255>at p.e746_s752>i c.2236_2256>atc p.e746_s752>i c.2236_2256del21 p.e746_s752delelreats c.2236_2257>ctct p.e746_p753>ls c.2236_2257>ctct/c.2237_2257>tct/c.2239_2257>t/ c.2240_2257del18/c.2257c>t p.e746_p753>ls/p.e746_ P753>VS/p.L747_P753>S/p. L747_P753>S/p.P753S 13200/18427/ / 12370/6268 c.2236_2259>atctcg p.e746_p753>is NA c.2236g>a/c.2236_2248>agac/c.2236_2250del15/ c.2236_2252>at/c.2236_2253>attcct/c.2236_2255>at/ c.2236_2256>atc/c.2236_2259>atctcg p.e746k/p.e746_a750>rp/p. E746_A750delELREA/p. E746_T751>I/p.E746_T751>IP/p. E746_S752>I/p.E746_S752>I/p. E746_P753>IS 13184/12413/622 5/26680/51526/ /133190/
3 Variant List OncoFOCUS v3 Panel (PAGE 3 OF 8) c.2237_2238aa>tt/c.2237_2250>tccct/ c.2237_2251>tgg/c.2237_2251>ttc/c.2237_2252>t/ c.2237_2253>ta/c.2237_2253>tc/c.2237_2253>ttcct/ c.2237_2253>ttgct/c.2237_2255>t/c.2237_2256>tc/ c.2237_2256>tg/c.2237_2256>tt/c.2237_2257>tct/ c.2237_2258>ttca p.e746v/p.e746_a750>vp/p. E746_T751>VA/p.E746_ T751>VP/p.E746_T751>V/p.E746_ T751>V/p.E746_T751>V/p.E746_ T751>VP/p.E746_T751>VA/p. E746_S752>V/p.E746_S752>V/p. E746_S752>V/p.E746_S752>V/p. E746_P753>VS/p.E746_P753>VQ 51497/28623/53 205/18421/1238 6/133192/ /52935/12416/12 384/18426/ /133194/18427 /51524 c.2237_2250>tccct p.e746_a750>vp c.2237_2251>tgg p.e746_t751>va c.2237_2251>ttc p.e746_t751>vp c.2237_2251del15 p.e746_t751>a c.2237_2252>t p.e746_t751>v c.2237_2253>tc p.e746_t751>v c.2237_2253>ttcct/c.2237_2253>ttgct p.e746_t751>vp/p.e746_ T751>VA 52935/12416 c.2237_2254del18 p.e746_s752>a c.2237_2255>t p.e746_s752>v c.2237_2256>tc p.e746_s752>v c.2237_2256>tt/c.2238_2255>gcaaca/ c.2238_2255del18/c.2255c>a p.e746_s752>v/p.l747_ S752>QH/p.E746_S752>D/p. S752Y /12421/ 6220/13186 c.2237_2257>tct p.e746_p753>vs c.2237_2258>ttca p.e746_p753>vq c.2238_2248>gc p.l747_a750>p c.2238_2248>tc p.e746_a750>dp NA c.2238_2251>gc p.l747_t751>p c.2238_2252>gca p.l747_t751>q c.2238_2255>gcaaca p.l747_s752>qh c.2238_2255del18 p.e746_s752>d 6220 c.2238_2256>gcaa p.l747_s752>q c.2239_2240tt>cc/c.2239_2248ttaagagaag>c/ c.2239_2250>cca/c.2239_2251>c/c.2239_2252>ca/ c.2239_2253>caa/c.2239_2253>ccaacg/ c.2239_2256>caa/c.2239_2256>caacat/ c.2239_2256del18/c.2239_2258>ca p.l747p/p.l747_a750>p/p. L747_A750>P/p.L747_T751>P/p. L747_T751>Q/p.L747_T751>Q/p. L747_T751>PT/p.L747_S752>Q/p. L747_S752>QH/p.L747_ S752delLREATS/p.L747_P753>Q 24267/12382/ /12383/12420 /51527/ / 12403/133196/62 55/12387 c.2239_2247del(9)ttaagagaa p.l747_e749del NA c.2239_2247delttaagagaa/c.2239_2253>gct/ c.2239_2262del24/c.2239_2264>gccaa p.l747_e749dellre/p. L747_T751>A/p.L747_ K754delLREATSPK/p.L747_ A755>AN 6218/23572/ 24970/85891 c.2239_2248ttaagagaag>c p.l747_a750>p c.2239_2251>c p.l747_t751>p
4 Variant List OncoFOCUS v3 Panel (PAGE 4 OF 8) c.2239_2252>ca p.l747_t751>q c.2239_2253>gct p.l747_t751>a c.2239_2255>caaca p.l747_s752>qh NA c.2239_2256>caa/c.2239_2256del18 p.l747_s752>q/p.l747_ S752delLREATS 12403/6255 c.2239_2258>ca p.l747_p753>q c.2240_2251del12 p.l747_t751>s 6210 c.2240_2254del15/c.2239_2253del15 p.l747_t751dellreat/p.l747_ T751delLREAT 12369/6254 c.2240_2257del18 p.l747_p753>s c.2240t>c/c.2240_2251del12/c.2240_2254del15/ c.2240_2257del18/c.2240_2261>cgac p.l747s/p.l747_t751>s/p.l747_ T751delLREAT/p.L747_P753>S/p. L747_K754>ST 26704/6210/ 12369/12370/ c.2248g>c p.a750p 6219 c.2251_2277>tcc p.t751_i759>s c.2251_2277>tct/c.2252_2277>at/c.2257_2277del21 p.t751_i759>s/p.t751_i759>n/p. P753_I759delPKANKEI 22945/24270/ c.2252_2275>g/c.2252_2277>gagaagcg p.t751fs*4/p.t751_i759>rea 12410/22956 c.2252_2276>a p.t751_i759>n c.2252_2276>a/c.2276t>a p.t751_i759>n/p.i759n 96856/23633 c.2252_2277>at p.t751_i759>n c.2252_2277>gagaagcg p.t751_i759>rea c.2252c>t p.t751i c.2252c>t/c.2252_2275del24 p.t751i/p.t751_ E758delTSPKANKE 13185/ c.2253_2276del24 p.s752_i759delspkankei c.2254_2277del24 p.s752_i759delspkankei 6256 c.2254t>c p.s752p c.2257_2277del21 p.p753_i759del NA c.2258c>a p.p753q NA c.2281g>a/c.2281g>t p.d761n/p.d761y 13188/21984 c.2298_2299insgccata p.m766_a767insai NA c.2302_2303inscgctggcca/c.2303g>c p.a767_s768instla/p.s768t 12425/ c.2303g>a p.s768n c.2303g>t/c.2303_2305gcg>tct p.s768i/p.s768_v769>il 6241/85750 c.2307_2308instgcgtg p.v769_d770inscv c.2308_2309insccagcgtgg/ c.2309_2312acaa>ctggtgg c.2308_2309insgcagcgtgg/ c.2308_2309insgggtcgtgg/c.2308_2309insgtt p.v769_d770insasv/p.d770_ N771>AGG p.v769_d770insgsv/p.v769_ D770insGVV/p.D770>GY 12426/ /18430/ c.2308_2315gacaaccc>ccagcgtggataaccg p.d770_p772>asvdnr NA 4
5 Variant List OncoFOCUS v3 Panel (PAGE 5 OF 8) c.2308g>a p.d770n c.2309_2310ins(14)atggccagcgtgga p.d770fs*61(3' Detetion Only) c.2309_2310ac>ccagcgtggat p.v769_d770insasv NA c.2309_2312acaa>ctggtgg p.d770_n771>agg c.2310_2311insgcaccgtgg p.d770_n771insapw c.2310_2311insgcaccgtgg/c.2310_2311insggc/ c.2310_2311insggggac/c.2310_2311insgggtta/ c.2310_2311insgggttt/c.2310_2311insggt/ c.2311a>ggtt/c.2311_2312aa>gggtt p.d770_n771insapw/p.d770_ N771insG/p.D770_N771insGD/p. D770_N771insGL/p.D770_ N771insGF/p.D770_N771insG/p. N771>GY/p.N771>GF 20886/13004/85 795/48921/ /12378/53189/ c.2310_2311insgggtta p.d770_n771insgl c.2310_2311insggt p.d770_n771insg c.2311_2312aa>gggtt p.n771>gf c.2311_2312ins(12)tggccaccccca c.2311_2312insaccggc/c.2311_2312inscac/ c.2311_2312insgtc p.d770_ N771insMATP(5'DetetionOnly) p.n771_p772insrh/p. N771>TH/p.N771>SH NA /22946/ c.2311_2312inscac p.n771>th c.2311_2312insgcgtggaca/c.2311_2312insgtc p.d770_n771inssvd/p.n771>sh 13428/24434 c.2311_2312insgtc p.n771>sh c.2311a>ggtt p.n771>gy c.2312_2315accc>gcgtggacaaccg p.n771_p772>svdnr NA c.2313_2314insaac c.2315_2316insggt c.2315_2316insccacgt/c.2319_2320inscac p.n771_p772insn(3' Detetion Only) p.p772_h773insv(3' Detetion Only) p.v774_c775inshv/p.h773_ V774insH /12377 c.2316_2317inscacgtg p.v774_c775inshv c.2317_2317c>aacccct p.h773>npy(3'detetiononly) NA c.2319_2320ins(9)aacccccac p.h773_v774insnph NA c.2319_2320insaacccccac/c.2320g>a p.h773_v774insnph/p.v774m 12381/13006 c.2319_2320inscac p.h773_v774insh NA c.2319_2320inscac/c.2319_2320inscag/ c.2319_2320insccccac p.h773_v774insh/p.h773_ V774insQ/p.H773_V774insPH 12377/131552/ c.2319_2320insccccac p.h773_v774insph NA c.2320g>t p.v774l c.2321_2322insccacgt p.v774_c775inshv NA c.2326c>t p.r776c 6226 c.2327g>a p.r776h c.2369c>t p.t790m 6240 c.2560a>g p.t854a
6 Variant List OncoFOCUS v3 Panel (PAGE 6 OF 8) KIT KRAS c.2572c>a/c.2572_2573ct>aa/c.2572_2573ct>ag c.2573t>g/c.2573_2574tg>ga/c.2573_2574tg>gt p.l858m/p.l858k/p.l858r p.l858r/p.l858r/p.l858r 12366/24268/ /133630/ c.2582t>a/c.2582t>g p.l861q/p.l861r 6213/12374 c.323g>a p.r108k c.787a>c p.t263p c.866c>t/c.866c>a p.a289v/p.a289d 21687/21685 c.1669t>c p.w557r 1219 c.1669t>g p.w557g 1221 c.1676t>a p.v559d 1252 c.1676t>c p.v559a 1255 c.1676t>g p.v559g 1253 c.1727t>c p.l576p 1290 c.1924a>c p.k642q c.1924a>g p.k642e 1304 c.2446g>c p.d816h 1311 c.2446g>t p.d816y 1310 c.175g>a p.a59t 546 c.176c>a p.a59e 547 c.176c>g p.a59g c.181c>a p.q61k 580 c.181c>g p.q61e 550 c.182a>c p.q61p 582 c.182a>g p.q61r 584 c.182a>t p.q61l 583 c.183a>c p.q61h 554 c.183a>t p.q61h 585 c.34_35gg>aa p.g12n c.34_35gg>at p.g12i c.34_35gg>ct p.g12l 514 c.34_35gg>ta p.g12y c.34_35gg>tt p.g12f 512 c.34_36ggt>tgc p.g12c 513 c.34_36ggt>tgg p.g12w c.34-35gg>ac p.g12t NA c.34-35gg>cc p.g12p NA c.34-36ggt>aga p.g12r NA c.349a>g p.k117e
7 Variant List OncoFOCUS v3 Panel (PAGE 7 OF 8) c.34g>a p.g12s 517 c.34g>c p.g12r 518 c.34g>t p.g12c 516 c.35_36gt>aa/c.36t>a p.g12e/p.g12g 519/524 c.35_36gt>ac/c.35_36gt>tc/c.36t>c p.g12d/p.g12v/p.g12g 14209/515/523 KRAS NRAS c.35_36gt>ag/c.36t>g/c.36_37insgcg/c.39_40insggc p.g12e/p.g12g/p.g12_ G13insA/p.G13_V14insG / / / c.350a>g p.k117r c.351a>c/351a>t p.k117n/k117n 19940/28519 c.35g>a p.g12d 521 c.35g>c p.g12a 522 c.35g>t p.g12v 520 c.36_37tg>at/c.37g>t p.g13c/p.g13c 87281/527 c.37_38gg>aa/c.38g>a p.g13n/p.g13d 24668/532 c.37_38gg>at/c.38g>t p.g13i/p.g13v 525/574 c.37g>a p.g13s 528 c.37g>c p.g13r 569 c.38g>c p.g13a 533 c.436g>c/c.436g>a p.a146p/p.a146t 19905/19404 c.437c>t/437c>g p.a146v/a146g 19900/ c.175g>a p.a59t 578 c.180_181ac>ta/c.181c>a p.q61k/p.q61k 12730/580 c.181_183caa>aag/c.183a>g p.q61k/p.q61q 53223/587 c.181c>g p.q61e 581 c.182_183aa>gg p.q61r c.182_183aa>tg p.q61l c.182a>c p.q61p 582 c.182a>g p.q61r 584 c.182a>t p.q61l 583 c.183a>c p.q61h 586 c.183a>t p.q61h 585 c.34_35gg>aa p.g12n c.34_35gg>cc p.g12p 559 c.349a>g p.k117e NA c.34g>t/c.34-35gg>ta p.g12c/y 562/560 c.35_36gt>ag p.g12e c.350a>g p.k117r NA c.351g>t/c p.k117n NA c.35g>c p.g12a 565 7
8 Variant List OncoFOCUS v3 Panel (PAGE 8 OF 8) c.35g>t p.g12v 566 c.37_38gg>aa p.g13n c.37_38gg>ta p.g13y 568 c.37g>c p.g13r 569 NRAS c.38g>a p.g13d 573 c.38g>c p.g13a 575 c.38g>t/c.38_39gt>tc p.g13v/p.g13v 574/572 c.436g>a p.a146t c.436g>c p.a146p NA c.436g>t p.a146s NA 8 Agena Bioscience, Inc Eastgate Mall San Diego, CA Phone: Order Desk: Order Desk Fax: orderdesk@agenabio.com Web: agenabio.com US GENOME EU AP CN ONC MassARRAY, iplex and Agena Bioscience are registered trademarks of Agena Bioscience, Inc. UltraSEEK is a trademark of Agena Bioscience, Inc Agena Bioscience, Inc. All rights reserved.
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