ORIGINAL ARTICLE. Corneal and Refractive Error Astigmatism in Singaporean Schoolchildren: a Vector-Based Javal s Rule

Size: px
Start display at page:

Download "ORIGINAL ARTICLE. Corneal and Refractive Error Astigmatism in Singaporean Schoolchildren: a Vector-Based Javal s Rule"

Transcription

1 /01/ /0 VOL. 78, NO. 12, PP OPTOMETRY AND VISION SCIENCE Copyright 2001 American Academy of Optometry ORIGINAL ARTICLE Corneal and Refractive Error Astigmatism in Singaporean Schoolchildren: a Vector-Based Javal s Rule LOUIS TONG, MBBS, FRCS, ANDREW CARKEET, BAppSc(Optom)(Hons), PhD, SEANG-MEI SAW, MBBS, PhD, and DONALD T. H. TAN, MBBS, FRCS, FRCO, FAMS Singapore National Eye Centre (LT, DTHT), Singapore Eye Research Institute (AC, DTHT), Department of Community, Occupational and Family Medicine, National University of Singapore (SMS) ABSTRACT: Background. Traditional approaches to Javal s rule do not use data from subjects with oblique astigmatism and have not been used to make predictions about subjects with oblique astigmatism. Vector approaches to analyzing refractive error can circumvent these problems. Methods. Subjects were 993 Singaporean schoolchildren. We performed linear regression of refractive error astigmatism on corneal astigmatism, using J 0 vectors to describe with-therule and against-the-rule astigmatism and J 45 vectors to describe oblique astigmatism. Results. We obtained the following statistically significant regression relationships: RJ CJ and RJ CJ , where R and C denote refractive error astigmatism and corneal astigmatism, respectively. Conclusion. Our vectorbased Javal s rule gives closer predictions of refractive astigmatism than the original Javal s rule and the simplified Javal s rule and can be applied in cases of corneal oblique astigmatism. (Optom Vis Sci 2001;78: ) Key Words: astigmatism, vectors, Javal s rule It has been known for more than a century that in humans, corneal astigmatism can be used to make clinically useful predictions about refractive error astigmatism. Based on his clinical patients, Javal 1 postulated an approximately linear relationship between refractive error astigmatism and corneal astigmatism: specifically that in the general population, refractive astigmatism could be calculated by multiplying corneal astigmatism by a constant p (which was approximately 1.25) and then adding an extra constant K (0.5 D against-the-rule) astigmatism. This rule has subsequently become known as Javal s rule. Javal s original rule was not based on a rigorous examination of data, but merely on Javal s own clinical impressions, and he noted that the values for coefficients p and K had not been definitively established. Later studies, performing more rigorous analyses, found a shallower gradient to the relationship. For example, from their empirical studies of 1058 eyes, Grosvenor et al. 2 determined the following regression equations: TA 0.76CA 0.40 D for myopic children; TA 0.84CA 0.32 D for patients at a university clinic; and TA 0.87CA 0.43 D for patients in an optometry practice; where TA is the total (or refractive error) astigmatism (the cylindrical component in the refractive error) and CA is the corneal astigmatism. In these relationships, positive values represent with-the-rule (WTR) astigmatism (in which the negative cylinder axis is oriented at 180 ) and negative values represent against-the-rule (ATR) astigmatism (in which the negative cylinder axis is oriented at 90. Thus, these relationships only apply to what we have termed Cartesian astigmatism: forms of astigmatism with their principal axes at 180 and 90. On the basis of these findings, Grosvenor et al. 2 devised what they termed their simplified Javal s Rule: TA CA 0.5 D. Other authors have shown similar linear relationships between corneal astigmatism and refractive error astigmatism in different populations, with slopes varying around 1 and slightly negative y intercepts. 3 9 There are, however, some interpretational problems with all of the previous Javal s rule studies, and they relate to the practicalities of determining Cartesian astigmatism. Patients seldom have corneal or refractive cylinder axes that lie exactly on 180 or 90, and thus definitions for WTR or ATR astigmatism need to encompass a wider range of axes than the horizontal and vertical. To address this issue, researchers often set boundary criteria on axes for WTR and ATR astigmatism, and these boundary criteria can vary for different authors. For example, in their research work, Grosvenor et al. 2 classify all negative cylinder axes between 150 and 30 (inclusive) as WTR and those be-

2 882 Vector-Based Javal s Rule Tong et al. tween 60 and 120 (inclusive) as ATR. All other axes are classified as oblique. This definition is also commonly found in textbooks, 10 although Rosenfield 11 defines WTR and ATR astigmatism more narrowly (negative cylinder axes 160 to 20 as WTR; 70 to 110 as ATR; and 20 to 70 and 110 to 160 as oblique). Other studies of Javal s rule 4, 5, 8 use even narrower boundaries for WTR and ATR, i.e., negative cylinder axes of 165 to 15 (inclusive) for WTR and 75 to 105 (inclusive) as ATR, with all other axes being oblique. In their research work on the etiology of myopia, Gwiazda et al. 12 adopted definitions whereby negative cylinder axes of were designated as ATR, designated as WTR, and all other axes designated as oblique. Setting boundary conditions in this way does present some problems for research into Javal s rule. First, when formulating the rule, subjects with axes classified as oblique (for cornea or refractive error) must be dropped from the analysis, thereby reducing the subject pool. Second, because most subjects do not have axes exactly on 90 or 180, most results included in analysis will be contaminated by some oblique cylinder component. Third, it is unclear how Javal s rule should be applied in practice for predicting refractive cylinder. Should it be applied to oblique astigmatism? If the corneal cylinder axis does not line up exactly with 180 or 90, should the refractive error cylinder be aligned with the Cartesian axes or left at the original cylinder axis? One way around these interpretational problems is to make use of vector methods advocated by Thibos et al. 13, which originated in the methods of Gartner 14 and Deal and Toop 15 and which are closely analogous to the methods used by McKendrick and Brennan 16 for analyzing refractive error and corneal astigmatism. This is an approach in which any refractive error can be expressed as a combination of three orthogonal components or thin lenses M, J 0, and J 45.Incommon clinical terms, M is equal to the spherical equivalent and is relatively unimportant for the purposes of studying astigmatism. The J 0 component can be thought of as a Jackson cross-cylinder (JCC) with its axes at 180 and 90. A positive value for J 0 denotes that the negative cylinder axis of the JCC is at 180, and a negative value denotes that the negative cylinder axis of the JCC is at 90. Thus, J 0 can be used for quantifying Cartesian astigmatism. A patient with a large amount of WTR astigmatism would have a high positive J 0, and, likewise, a large amount of ATR astigmatism would manifest as a highly negative J 0. McKendrick and Brennan 16 made similar observations about their vector i 1 which is equal to 2 J 0. Thus, regression of J 0 for refractive error against J 0 for the cornea could be one way of deriving equations similar to Javal s rule. All subjects in a sample can be included in such an analysis because a J 0 value can be calculated for any refractive error or corneal cylinder. The J 45 component can be thought of as a JCC with its axes at 45 and 135. A positive value for J 45 denotes that the negative cylinder axis of the JCC is at 45, and a negative value denotes that the negative cylinder axis of the JCC is at 135. Thus J 45 might be thought of as quantifying the amount of oblique astigmatism in a refractive error. McKendrick and Brennan 16 used a similar vector i 2 which is equal to 2 J 45. From a clinical perspective, oblique astigmatism is often treated as a single category, but it is possible to split into two categories (in the same way that ATR and WTR are a dichotomy). Negative cylinder axes that are closest to 45 (i.e., positive J 45 ) we term levo-oblique (LO) astigmatism, and those that are close to 135 (i.e., negative J 45 ) we term dextro-oblique DO astigmatism. Although it has never been done before, it is possible to frame rules like Javal s rule for oblique astigmatism (i.e., by regression of refractive error J 45 against corneal cylinder J 45 ). The purpose of this study was to apply this vector approach to Javal s rule in a sample of Singaporean schoolchildren. Because the vector approach allows for the analysis of data from all subjects and also provides information about oblique astigmatism, we expected that it would provide better and more general predictions of refractive error astigmatism than the traditional Javal s rule approaches. METHODS Subjects Some initial cross-sectional results of the Singapore Cohort Study of the Risk Factors of Myopia (SCORM), 17, 18 an ongoing longitudinal observational study that commenced in 1999, are reported here. This study was approved by the ethics committee of the Singapore Eye Research Institute, and all procedures adhered to the Declaration of Helsinki. Informed written consent was obtained from the subjects parents. All schoolchildren in grades I to III in a school in Eastern Singapore and a school in Northern Singapore were recruited for this study. Subjects with established eye pathology or amblyopia detected before the commencement of the study or with known allergy to eyedrops were excluded. The participation rate was 62%. We were able to obtain sufficient data for our analyses from 1004 subjects (505 females and 499 males) aged from 7 to 13 years (mean, ). Data from the right eyes of these subjects are reported in this study. Data Collection The measurements reported in this study were taken under cycloplegia, which was accomplished with three drops of topical 1% cyclopentolate in each eye, each drop instilled at 5-min intervals, after instillation of 0.5% proparacaine. Autorefraction and keratometry measurements were performed 30 min after the last drop instillation. Measurements were taken objectively using one of two Canon RK-5 autorefractor/autokeratometers (Canon, Tochigiken, Japan). For each subject, five refractive error measurements were taken, each converted from their sphero-cylinder notation to vector notation using the following equations 13 : M S C 2 (1) J 0 C cos2 (2) 2 J 45 C sin2 (3) 2 where S is sphere, C is cylinder power, and is cylinder axis. Results reported for individual subjects are the average of five sets of vectors. Corneal astigmatism was calculated based on the autokeratometry reading and assumes a corneal refractive index of We expressed corneal astigmatism as the correcting cylinder that would be combined with the corneal power to give zero astigmatism. Cylinder power was calculated as F min F max where F max and F min are the maximum and minimum corneal powers, respectively. Cyl-

3 Vector-Based Javal s Rule Tong et al. 883 inder axis was set at the corneal meridian along which power was minimum. Corneal astigmatism was then expressed as J 0 and J 45 vectors using the same equations listed above. Data Analysis We performed linear regression of refractive error astigmatism against corneal astigmatism for three different sets of variables. First, we regressed refractive error J 0 against corneal J 0. Second, we performed a similar regression using refractive error J 45 and corneal J 45. Finally, we performed the traditional Javal s rule analysis whereby refractive error cylinder power was regressed against corneal cylinder power, with ATR astigmatism being assigned negative values and WTR astigmatism being assigned positive values and subjects with oblique astigmatism in cornea or refractive error being excluded from the analysis. Our definitions of WTR and ATR astigmatism were, respectively, negative cylinder axes of inclusive and inclusive, with the remaining axes being classified as oblique, thereby matching criteria laid down by other researchers. 4, 5, 8 Occasionally, autokeratometry can provide cylinder power measurements that are both extremely inaccurate and extremely high, so we followed the example of previous researchers 5 and excluded very high corneal cylinder powers from our analyses. Our analyses were therefore performed using corneal cylinder powers of 4 D (i.e., 3 SD from the mean). This resulted in 11 cases being removed from the analyses, leaving a total of 993 subjects (494 male and 499 female) aged 7 to 13 years (mean, ). The cases that were excluded from the analysis had cylinder powers ranging from 4.13 to D (mean, D). RESULTS Our results showed strong linear relationships between refractive error astigmatism vectors and corneal astigmatism vectors, relationships that are very similar to Javal s rule. This is illustrated in Fig. 1, a plot of refractive error J 0 against corneal J 0, and in Fig. 2, a similar plot for J 45 vectors. In Fig. 1, the regression equation for refractive error J 0 (RJ 0 ) against corneal J 0 (CJ 0 ) was: FIGURE 1. Refractive error J 0 plotted against corneal J 0. The regression line shown represents Equation 4. ATR, against-the-rule astigmatism; WTR, with-therule astigmatism. determining coefficients for Javal s rule. In Fig. 3, refractive error cylinder power (TA) is plotted against corneal cylinder power (CA), WTR astigmatism is given a positive sign, and ATR astigmatism is given a negative sign. Oblique axes (more than 15 from the horizontal or vertical) were excluded in this plot. Under this criterion, 327 subjects had oblique astigmatism for refractive error, 110 subjects had oblique astigmatism for corneal cylinder, and 367 subjects had oblique astigmatism under either criterion (70 of RJ CJ D (4) The correlation coefficient was 0.835, which indicated a significant linear relationship (p 0.001). For the gradient in this relationship, 95% confidence limits were and For the y intercept, 95% confidence limits were and D. In Fig. 2, the regression equation for refractive error J 45 (RJ 45 ) against corneal J 45 (CJ 45 ) was RJ CJ D (5) The correlation coefficient was 0.691, which was significantly different from zero (p 0.001). For the gradient in this relationship, 95% confidence limits were and For the y intercept, 95% confidence limits were and D. When combined, Equations 4 and 5 can be used to predict refractive error astigmatism based on corneal astigmatism. We have termed this combination the vector-based Javal s rule. Fig. 3 shows our data analyzed using the traditional approach to FIGURE 2. Refractive error J 45 plotted against corneal J 45. The regression line shown represents Equation 5. DO, dextro-oblique astigmatism; LO, levo-oblique astigmatism.

4 884 Vector-Based Javal s Rule Tong et al. these were oblique for both the corneal and refractive error axes) and were excluded, leaving 626 subjects for this analysis. The regression equation for Fig. 3 is similar but not identical to that for Fig. 1 and is TA 0.985CA D (6) This relationship has a significant correlation coefficient of (p 0.001), with 95% confidence limits for the gradient of and For the y intercept, 95% confidence limits were and D. Thus, the gradient in Equation 4 is slightly flatter than in Equation 6. It should also be noted that the scales differ between Figs. 1 and 3. Fig. 1 is plotted in terms of Jackson cross-cylinders (as is Fig. 2), which have half of the dioptric value of the conventional cylindrical power used for plotting Fig. 3. When expressed in normal cylinder power (i.e., doubled), the confidence limits for the y intercept in Fig. 1 becomes D with 95% confidence limits of and D, overlapping the mean and confidence limits in Fig. 3. DISCUSSION Our vector-based Javal s rule represents an improvement on previous approaches to Javal s rule because in formulating it: (1) we did not exclude subjects whose axes did not lie close to Cartesian axes and (2) we included information about oblique axes and Cartesian axes in its formulation. Likewise, the vector-based Javal s rule can be used to make predictions about refractive astigmatism regardless of orientation of the subject s corneal cylinder axis, predictions that will provide information about oblique and Cartesian components of refractive error astigmatism. The slopes and intercepts in Equations 4 and 6 are not significantly different (after matching scales); thus, for our subjects, our FIGURE 3. Refractive error cylinder magnitude plotted against corneal cylinder magnitude. Negative cylinder axes outside and were excluded from the analysis. With-the-rule astigmatism (WTR) astigmatism was designated positive, and against-the-rule (ATR) astigmatism was designated negative. The regression line shown represents Equation 7. vector-based Javal s rule gives similar results to the traditional approach to Javal s rule. In addition, the slopes and intercepts are also similar to those found by previous studies. We note that McKendrick and Brennan 16 performed a very similar correlation analysis for corneal and total astigmatism using their vectors i 1 and i 2 (scale equivalents of J 0 and J 45, respectively). Their correlation coefficients (r) were slightly lower than ours: 0.69 for the Cartesian meridians and 0.59 for the oblique meridians (right eye only), compared with our values of and for corresponding meridians. This difference can be accounted for by the larger population variance of refractive error astigmatism in our study. Correlation can be expressed in terms of the coefficient of determination, r 2, which is equal to the proportion of variance of one variable that can be explained in a linear model by variance of the second variable. Sample variance in our refractive error J 0 data was D 2, and for McKendrick and Brennan, this was D 2. Thus, based on r 2 values, D 2 of our refractive error J 0 variance can be predicted from variance of corneal J 0, compared with D 2 for McKendrick and Brennan. However, the residual (uncorrelated with cornea) variance in refractive error J 0 of 0.04 D 2 for our study was almost identical with D 2 for McKendrick and Brennan. This residual variance can be thought of as a measure of the variance of the data above and below the regression line, i.e., noise in the refractive error data J 0, that isn t explained by corneal J 0. Similar calculations, using r 2 and the refractive error J 45 sample variance of D 2 for our study and D 2 for McKendrick and Brennan, yield residual variance for refractive error J 45 of D 2 for both studies. Thus, correlation leaves similar amounts of unexplained refractive error astigmatism variance for both our study and that of McKendrick and Brennan. The difference in correlation coefficients for the two studies can therefore be explained in terms of the larger overall variance in refractive error astigmatism in our study. This difference may be due to the different ethnic groups and ages of subjects in each study, our subjects being Asian children and McKendrick and Brennan using young Australian adults from a broad range of socioeconomic backgrounds. 16 To our knowledge, we are the first group to describe the regression relationship between the oblique components of corneal and refractive error astigmatism. The small slope and intercept of Equation 5 imply that the oblique components of refractive astigmatism are usually less in magnitude than the oblique components of corneal astigmatism. This is true, with the average difference between magnitudes of corneal J 45 and refractive error J 45 being D (t , p 0.001) This result seems paradoxical, given that in our traditional Javal s rule analysis we excluded only 110 subjects with oblique corneal cylinders, but 367 subjects with oblique refractive error cylinders. (This trend can be confirmed by reviewing axis orientation; 664 subjects had refractive error axes that were more oblique than corneal cylinder axes, and 315 subjects showed the reverse trend.) So why does a shift to smaller refractive error J 45 lead to a greater tendency to oblique refractive error axes? This interesting effect arises because most cases of corneal astigmatism have negative cylinder axes that lie close to, but not exactly on, 180 and are greater than approximately 0.25 D in magnitude. For such cylinders, obliquely crossing them with the approximately 0.5 D ATR astigmatism implied by the intercepts in Equations 4 and 6 results in a more oblique final axis. Thus, these more oblique refractive error axes are a consequence of an againstthe-rule (i.e., nonoblique) shift and might have been predicted

5 Vector-Based Javal s Rule Tong et al. 885 based on previous versions of Javal s rule. To our knowledge, though, we are the first to observe that one of the consequences of Javal s rule is a tendency for refractive error axes to be more oblique than corneal astigmatism axes. If corneal astigmatism was the sole cause of refractive error astigmatism, the gradients in Equations 4, 5, and 6 would be equal to 1, and the intercepts would be equal to zero. Previous researchers have suggested a number of reasons why this does not occur in practice, including misalignment of the corneal or crystalline lens optic axis with the line of sight, crystalline lens astigmatism, vertex distance effects, and inappropriate refractive index being used for keratometry conversions. 2, 6 Because of the particular ethnic composition of this study population, which consisted primarily of Chinese children (75%) with a smaller proportion of Malay (20%) and Indian (5%) representation, our results may not necessarily be applicable to other populations. It should be noted, though, that Javal s rule seems to apply reasonably well across different ethnic groups, 2, 4 6, 8 although ethnic variability in the prevalence of astigmatism has been reported 16 20, with average levels of astigmatism in the Native American population being higher than other populations in the United States All these epidemiological studies have not, however, compared the vector components of the astigmatism between ethnic groups. Because SCORM is a longitudinal study, we intend to present the change in the astigmatism in these children using similar vector methods. Clinical Utility of Vector-Based Javal s Rule We have developed a vector-based Javal s rule, which allows information about corneal Cartesian and oblique astigmatism to FIGURE 4. Accuracy of predictions based on different versions of Javal s rule. Relative frequency histograms show residual refractive error cylinder power (difference between predictions and obtained values) for different versions of Javal s rule. For reference, refractive error cylinder magnitude is plotted in the top frame. be used to predict refractive error astigmatism. To assess the clinical utility of this vector-based Javal s rule, for each subject we calculated how much residual cylindrical power (C res ) would remain uncorrected if the vector-based Javal s rule was used to calculate astigmatism (i.e., if a cylinder was prescribed using our vector-based Javal s rule, C res would be the cylinder power to be added at the appropriate axis to give the actual refractive error cylinder). Predicted RJ 0 and RJ 45 (PRJ 0 and PRJ 45 ) were found by modifying Equations 4 and 5: PRJ CRJ D (7) PRJ CRJ D (8) The predicted refractive error minus cylinder power (PC) and negative cylinder axis (PA) are given by PC 2 PRJ 0 2 PRJ 45 2 ) (9) PA 1 2 tan 1 PRJ 45 PRJ 0 (10) (using a four-quadrant tan 1 function in Equation 10). C res was calculated as follows: C res 2 PRJ 0 RJ 0 ) 2 PRJ 45 RJ 45 ) 2 ) (11) If the vector-based Javal s rule was used to estimate refractive error cylinder, the results would differ from the measured refractive error by cylinders of 0.25 D in 36% of cases, 0.50 D in 77% of cases, and 0.75 D in 92% of cases (mean, D; median, 0.32 D). We compared these results with predictions based on Javal s original rule 1 and the simplified Javal s rule. 2 Our approach to these rules differs from previous researchers in that we decided to apply them to cases of oblique corneal astigmatism as well as the traditional Cartesian axes. This version of the simplified Javal s rule might be expressed as the following: TA can be calculated by crossing a cylinder of 0.50 D 90 with corneal astigmatism. This is easily accomplished with the following equations: PRJ 0 CRJ D and PRJ 45 CRJ 45, with C res calculated using Equation 11. The original Javal s rule might be expressed as the following: TA can be calculated by multiplying corneal cylinder by 1.25 (axis unchanged) and crossing this with a cylinder of 0.50 D 90. This can be accomplished numerically as PRJ CRJ D and PRJ CRJ 45, again with C res calculated using Equation 11. Residual cylinders for the simplified Javal s rule are slightly and significantly worse (t , p 0.001) than for the vector-based Javal s rule, with only 28% being smaller than 0.25 D, 70% being smaller than 0.50 D, and 89% being smaller than 0.75 D (mean, D, median 0.37 D). The original Javal s rule gives significantly worse residual cylinder powers than the vector-based Javal s rule (t , p 0.001) and the simplified Javal s rule (t , p 0.001), with 15% being smaller than 0.25 D, 44% being smaller than 0.50 D, and 73% being smaller than 0.75 D (mean, D; median, 0.54 D). For visual comparison of the different rules, relative frequency histograms of C res values are plotted in Fig. 4 along with the residual cylinders if no attempt was made to correct astigmatism.

6 886 Vector-Based Javal s Rule Tong et al. Thus, it appears that the vector-based Javal s rule and the simplified Javal s rule have some clinical usefulness because for a large percentage of cases, they can provide a close match for refractive error astigmatism. Although autorefractors are becoming increasingly common in ophthalmic practices, they are far from ubiquitous. Thus, astigmatism estimates based on keratometry can prove useful starting points for subjective refraction. When applying the vector based Javal s rule to left eyes, the y intercept should be set to 0.01 in Equation 8 to take into account midline asymmetry, or the small intercept could be ignored completely for left and right eyes. We recognize that using Equations 4, 5, 7, 8, 9, and 10 to estimate refractive error astigmatism might prove cumbersome in a clinical setting. However, the same operations can be accomplished in seconds using graphical techniques described in the Appendix. CONCLUSION We have developed a vector approach to Javal s rule, in which Cartesian astigmatism is represented by J 0 vectors and oblique astigmatism is represented by J 45 vectors. This approach is closely analogous to the traditional approach to Javal s rule, but the ability to make predictions about oblique astigmatism makes the vector-based rule more general and more accurate. In our sample of 993 Singaporean schoolchildren, we found that our vector-based rule could be used to predict cylinder powers to within 0.32 D in 50% of cases and to with 0.75 D in 92% of cases and thus may provide clinically useful information. APPENDIX Graphical Approaches to Vector-Based Javal s Rule and Simplified Javal s Rule Implementing the vector-based Javal s rule involves using Equations 4, 5, 7, 8, 9, and 10. Even in the case of the simplified Javal s rule Grosvenor et al. 2 felt that the rule should be confined to Cartesian meridians, in part to avoid the mathematics of obliquely FIGURE 5. Graphical method for applying the vector-based Javal s rule. See description in the Appendix (along with a method of applying the simplified Javal s rule to oblique meridians). FIGURE 6. Examples of graphical method for Javal s rule. Example A (hatched circles) shows calculations for the vector-based Javal s rule. Example B (x s) shows calculations for the simplified Javal s rule.

7 crossed cylinders. Although modern calculators, computers, and spreadsheets make such mathematics feasible in a clinical setting, graphical techniques can also provide rapid solutions to these problems. Fig. 5 and the examples in Fig. 6 show the framework for such graphical techniques. They can be implemented as follows. Vector-Based Javal s Rule The corneal cylinder and negative cylinder axis is plotted on the double polar plot in the upper part of Fig. 5, and the corneal J 0 and J 45 vectors are then read off the grid plot (interpolation on plotting and reading vectors will improve accuracy). These J 0 and J 45 vectors are then replotted on the double polar plot in the lower part of Fig. 5. (The scale changes and shifting of these vector coordinates have been calculated from Equations 7 and 8, although we have ignored the very small intercept from Equation 8.) The estimate of refractive error cylinder power and negative cylinder axis can be read directly from the double polar plot (again with interpolation). This is shown in example A, plotted in Fig. 6 using the hatched circles. From K readings of D at 15 and D at 105, the corneal cylinder is (specified in terms of the cylinder required to correct corneal astigmatism). This cylinder power and negative cylinder axis is plotted on the upper double polar diagram, and the J 0 and J 45 vectors are read off as approximately 0.37 and 0.62 D, respectively. These J 0 and J 45 vectors are then plotted on the lower diagram, and the estimate of refractive error astigmatism can be read off the double polar plot, giving approximately 0.75 D 20. This is close to the numerically calculated value of Simplified Javal s Rule Again, the corneal cylinder is plotted on the double polar plot in the upper part of Fig. 5. This point is then replotted one grid line to the left on the same diagram (this corresponds to 0.5 D cylinder ATR shift, which is equivalent to a 0.25 D change in the J 0 component of the astigmatism), and the refractive error astigmatism is read from the same double polar diagram. Again, interpolation at each of these stages will improve the accuracy of the final result. Example B, which is plotted as the x s in Fig. 6, shows how to use a simplified Javal s rule with a double polar diagram. For K readings of D at 160 and D at 70, corneal cylinder is This cylinder power and axis is plotted on the upper double polar diagram (rightmost x). This point is then replotted one grid line to the left (it is probably not necessary to read any J 0 or J 45 vectors off the graph, but rather just measure or estimate the distance of one grid line). The estimate of refractive error astigmatism can be read off the double polar plot, giving approximately 0.75 D 145. This is close to the numerically calculated value of The simplified Javal s rule may be quicker to implement graphically than the vector-based Javal s rule but, as shown in the main body of the text, may be slightly less accurate ACKNOWLEDGMENT This study was supported by Singapore Eye Research Grant SERI/MG/97-04/0005. Received May 29, 2001; revision received August 22, REFERENCES Vector-Based Javal s Rule Tong et al Javal E. Memoires d Ophthalmometrie. G. Masson, ed. Paris: Librarie de l Academie de Medecine, 1890: Grosvenor T, Quintero S, Perrigin DM. Predicting refractive astigmatism: a suggested simplification of Javal s rule. Am J Optom Physiol Opt 1988;65: Heard T, Reber N, Levi D, Allen D. The refractive status of Zuni Indian children. Am J Optom Physiol Opt 1976;53: Dobson V, Miller JM, Harvey EM, Tyszko RM. The relation between corneal and refractive astigmatism in a preschool population with a high prevalence of astigmatism. Invest Ophthalmol Vis Sci 1998;39:S Dobson V, Miller JM, Harvey EM. Corneal and refractive astigmatism in a sample of 3- to 5-year-old children with a high prevalence of astigmatism. Optom Vis Sci 1999;76: Auger P. Confirmation of the Simplified Javal s Rule. Am J Optom Physiol Opt 1988;65: Elliott M, Callender MG, Elliott DB. Accuracy of Javal s rule in the determination of spectacle astigmatism. Optom Vis Sci 1994;71: Keller PR, Collins MJ, Carney LG, Davis BA, van Saarloos PP. The relation between corneal and total astigmatism. Optom Vis Sci 1996;73: Grosvenor T, Ratnakaram R. Is the relation between keratometric astigmatism and refractive astigmatism linear? Optom Vis Sci 1990;67: Grosvenor TP. Anomalies of refraction. In: Grosvenor TP, ed. Primary Care Optometry, 2nd ed. New York: Professional Press Books, 1989: Rosenfield M. Refractive status of the eye. In: Benjamin WJ, Borish IM, eds. Borish s Clinical Refraction. Philadelphia: WB Saunders, 1998: Gwiazda J, Grice K, Held R, McLellan J, Thorn F. Astigmatism and the development of myopia in children. Vision Res 2000;40: Thibos LN, Wheeler W, Horner D. Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error. Optom Vis Sci 1997;74: Gartner W. Astigmatism and optometric vectors. Am J Optom Arch Am Acad Optom 1965;42: Deal FC Jr, Toop J. Recommended coordinate systems for thin spherocylindrical lenses. Optom Vis Sci 1993;70: McKendrick AM, Brennan NA. Distribution of astigmatism in the adult population. J Opt Soc Am A 1996;13: Saw SM, Chua WH, Wu HM, Hong CY, Chan WM, Chia KS, Tan D. Design and Initial Results of the Singapore Myopia Cohort Study. In: Thorn N, Troilo S, Gwiazda J, eds. Myopia 2000: Proceedings of the VIII International Conference on Myopia. Boston: New England College of Optometry, Schepens Eye Research Institute, 2000: Saw SM, Wu HM, Hong CY, Chua WH, Chia KS, Tan D. Myopia and night lighting in children in Singapore. Br J Ophthalmol 2001;85: Fuller JR, Baxter LA, Harun S, Levy IS. Astigmatism in Bangladeshi and white school entrants in East London: a prospective comparative study. Eye 1995;9: Katz J, Tielsch JM, Sommer A. Prevalence and risk factors for refractive errors in an adult inner city population. Invest Ophthalmol Vis Sci 1997;38: Goss DA. Meridional analysis of with-the-rule astigmatism in Oklahoma Indians. Optom Vis Sci 1989;66: Wick B, Crane S. A vision profile of American Indian children. Am J Optom Physiol Opt 1976;53: Hamilton JE. Vision anomalies of Indian school children: the Lame Deer study. J Am Optom Assoc 1976;47: Louis Tong Singapore National Eye Center 11 Third Hospital Avenue Singapore Louistong@hotmail.com

Research conducted over the past 15 years has yielded a

Research conducted over the past 15 years has yielded a Visual Psychophysics and Physiological Optics Longitudinal Change and Stability of Refractive, Keratometric, and Internal Astigmatism in Childhood Erin M. Harvey, 1,2 Joseph M. Miller, 1 3 J. Daniel Twelker,

More information

Predicting of Uncorrected Astigmatism from Decimal Visual Acuity in Spherical Equivalent

Predicting of Uncorrected Astigmatism from Decimal Visual Acuity in Spherical Equivalent Journal of the Optical Society of Korea Vol. 17, No. 2, April 2013, pp. 219-223 DOI: http://dx.doi.org/10.3807/josk.2013.17.2.219 Predicting of Uncorrected Astigmatism from Decimal Visual Acuity in Spherical

More information

Astigmatism in Children: Changes in Axis and Amount from Birth to Six Years

Astigmatism in Children: Changes in Axis and Amount from Birth to Six Years Astigmatism in Children: Changes in Axis and Amount from Birth to Six Years Jane Gwiazda, Mitchell Scheiman,* Indra Mohindra, and Richard Held Noncycloplegic refractions of, children aged - years revealed

More information

The Pattern of Astigmatism in a Canadian Pre-School Population. Number of words in text: 5371 Number of words in abstract: 199

The Pattern of Astigmatism in a Canadian Pre-School Population. Number of words in text: 5371 Number of words in abstract: 199 Laura Cowen 1 The Pattern of Astigmatism in a Canadian Pre-School Population Laura Cowen 1 and William R. Bobier 2 1 Department of Statistics and Actuarial Sciences, 2 School of Optometry, University of

More information

Astigmatic axis and amblyopia in childhood

Astigmatic axis and amblyopia in childhood Astigmatic axis and amblyopia in childhood Maths Abrahamsson and Johan Sjo strand ABSTRACT. Purpose: This study is part of a larger project whose aim is to evaluate the relationship between refractive

More information

Astigmatism is a common refractive error 1 and an important. The Changing Profile of Astigmatism in Childhood: The NICER Study

Astigmatism is a common refractive error 1 and an important. The Changing Profile of Astigmatism in Childhood: The NICER Study Clinical and Epidemiologic Research The Changing Profile of Astigmatism in Childhood: The NICER Study Lisa O Donoghue, Karen M. Breslin, and Kathryn J. Saunders School of Biomedical Sciences, University

More information

Handheld Shack Hartmann Wavefront Sensor. Jim Schwiegerling, Ph.D. Department of Ophthalmology and Optical Sciences The University of Arizona

Handheld Shack Hartmann Wavefront Sensor. Jim Schwiegerling, Ph.D. Department of Ophthalmology and Optical Sciences The University of Arizona Handheld Shack Hartmann Wavefront Sensor Jim Schwiegerling, Ph.D. Department of Ophthalmology and Optical Sciences The University of Arizona COLLABORATORS Erin M. Harvey, PhD Velma Dobson, PhD Joseph M.

More information

ORIGINAL ARTICLE. Amblyopia in Astigmatic Infants and Toddlers

ORIGINAL ARTICLE. Amblyopia in Astigmatic Infants and Toddlers 1040-5488/10/8705-0330/0 VOL. 87, NO. 5, PP. 330 336 OPTOMETRY AND VISION SCIENCE Copyright 2010 American Academy of Optometry ORIGINAL ARTICLE Amblyopia in Astigmatic Infants and Toddlers Velma Dobson*,

More information

Cycloplegic Refractions of Infants and Young Children: The Axis of Astigmatism

Cycloplegic Refractions of Infants and Young Children: The Axis of Astigmatism Cycloplegic Refractions of Infants and Young Children: The Axis of Astigmatism Velma Dobson,* Anne B. Fulton, f and S. Lawson Sebris* Review of the cycloplegic refractions of all children who were first

More information

balt5/zov-opx/zov-opx/zov01005/zov a washingd S 12 10/4/05 14:54 Art: OPX Input-nlm ORIGINAL ARTICLE

balt5/zov-opx/zov-opx/zov01005/zov a washingd S 12 10/4/05 14:54 Art: OPX Input-nlm ORIGINAL ARTICLE 1040-5488/05/8210-0001/0 VOL. 82, NO. 10, PP. 1 1 OPTOMETRY AND VISION SCIENCE Copyright 2005 American Academy of Optometry ORIGINAL ARTICLE Progressive Powered Lenses: the Minkwitz Theorem JAMES E. SHEEDY,

More information

NIH Public Access Author Manuscript Optom Vis Sci. Author manuscript; available in PMC 2011 May 1.

NIH Public Access Author Manuscript Optom Vis Sci. Author manuscript; available in PMC 2011 May 1. NIH Public Access Author Manuscript Published in final edited form as: Optom Vis Sci. 2010 May ; 87(5): 330 336. doi:10.1097/opx.0b013e3181d951c8. Amblyopia in Astigmatic Infants and Toddlers Velma Dobson,

More information

Eyes with regular astigmatism have two orthogonal focal. Accommodation in Astigmatic Children During Visual Task Performance

Eyes with regular astigmatism have two orthogonal focal. Accommodation in Astigmatic Children During Visual Task Performance Clinical and Epidemiologic Research Accommodation in Astigmatic Children During Visual Task Performance Erin M. Harvey, 1,2 Joseph M. Miller, 1 3 Howard P. Apple, 1 Pavan Parashar, 4 J. Daniel Twelker,

More information

4/9/2016. Sources of. Single-angle vs. double-angle plots for astigmatism data. Commercial Toric IOL calculators. Unexpected residual astigmatism!

4/9/2016. Sources of. Single-angle vs. double-angle plots for astigmatism data. Commercial Toric IOL calculators. Unexpected residual astigmatism! Sources of Corneal astigmatism measurements Methods of calculation Corneal surgically induced astigmatism (SIA) Toric IOL misalignment Unexpected residual astigmatism! Single-angle vs. double-angle plots

More information

FEATURE ARTICLE ON LINE. Anisometropia Prevalence in a Highly Astigmatic School-Aged Population

FEATURE ARTICLE ON LINE. Anisometropia Prevalence in a Highly Astigmatic School-Aged Population 1040-5488/08/8507-0512/0 VOL. 85, NO. 7, PP. E512 E519 OPTOMETRY AND VISION SCIENCE Copyright 2008 American Academy of Optometry FEATURE ARTICLE ON LINE Anisometropia Prevalence in a Highly Astigmatic

More information

Onset and Progression of With-the-Rule Astigmatism in Children with Infantile Nystagmus Syndrome

Onset and Progression of With-the-Rule Astigmatism in Children with Infantile Nystagmus Syndrome Visual Psychophysics and Physiological Optics Onset and Progression of With-the-Rule Astigmatism in Children with Infantile Nystagmus Syndrome Jingyun Wang, Lauren M. Wyatt, Joost Felius,, David R. Stager,

More information

Ahigh prevalence of astigmatism has been documented

Ahigh prevalence of astigmatism has been documented Clinical and Epidemiologic Research Prevalence of Corneal Astigmatism in Tohono O odham Native American Children 6 Months to 8 Years of Age Erin M. Harvey, 1,2 Velma Dobson, 1,3 Joseph M. Miller, 1,2,4

More information

Total corneal astigmatism in older adults taking into account posterior corneal astigmatism by ray tracing

Total corneal astigmatism in older adults taking into account posterior corneal astigmatism by ray tracing ARTICLE Total corneal astigmatism in older adults taking into account posterior corneal astigmatism by ray tracing Alvaro Rodríguez Ratón, MD 1 ; Javier Orbegozo Gárate, MD 1 ; Iñaki Basterra Barrenetxea,OD

More information

in the Howard County Public School System and Rocketship Education

in the Howard County Public School System and Rocketship Education Technical Appendix May 2016 DREAMBOX LEARNING ACHIEVEMENT GROWTH in the Howard County Public School System and Rocketship Education Abstract In this technical appendix, we present analyses of the relationship

More information

1. Standard Equipment Subjective Eye Tester Name of Parts Details of Auxiliary Lenses Measuring Performance...

1. Standard Equipment Subjective Eye Tester Name of Parts Details of Auxiliary Lenses Measuring Performance... Notification Dear Users, Thank you for your purchase of R 2500 Refractor. Please take time to read our user s manual carefully before use. This guarantees you to make full use of this unit and prolongs

More information

Algebra I Module 2 Lessons 1 19

Algebra I Module 2 Lessons 1 19 Eureka Math 2015 2016 Algebra I Module 2 Lessons 1 19 Eureka Math, Published by the non-profit Great Minds. Copyright 2015 Great Minds. No part of this work may be reproduced, distributed, modified, sold,

More information

The eyes of neonates of all species studied have rather. Severe Astigmatic Blur Does Not Interfere with Spectacle Lens Compensation

The eyes of neonates of all species studied have rather. Severe Astigmatic Blur Does Not Interfere with Spectacle Lens Compensation A R T I C L E S Severe Astigmatic Blur Does Not Interfere with Spectacle Lens Compensation Rhondalyn C. McLean and Josh Wallman PURPOSE. Whether either natural emmetropization or compensation for imposed

More information

Research Article Visual Motor and Perceptual Task Performance in Astigmatic Students

Research Article Visual Motor and Perceptual Task Performance in Astigmatic Students Ophthalmology Volume 2017, Article ID 6460281, 7 pages https://doi.org/10.1155/2017/6460281 Research Article Visual Motor and Perceptual Task Performance in Astigmatic Students Erin M. Harvey, 1,2 J. Daniel

More information

Human Hair Studies: II Scale Counts

Human Hair Studies: II Scale Counts Journal of Criminal Law and Criminology Volume 31 Issue 5 January-February Article 11 Winter 1941 Human Hair Studies: II Scale Counts Lucy H. Gamble Paul L. Kirk Follow this and additional works at: https://scholarlycommons.law.northwestern.edu/jclc

More information

DOWNLOAD ASTIGMATIC TECHNIQUE IN ONE STEP RAINBOW HOLOGRAPHY

DOWNLOAD ASTIGMATIC TECHNIQUE IN ONE STEP RAINBOW HOLOGRAPHY ASTIGMATIC TECHNIQUE IN ONE PDF DOWNLOAD 1 / 5 2 / 5 3 / 5 astigmatic technique in one pdf astigmatic technique in one pdf Signs and symptoms. Although astigmatism may be asymptomatic, higher degrees of

More information

* Villegas EL, Alcón E, Artal P. Minimum amount of astigmatism that should be corrected. J Cataract Refract Surg 2014; 40: n My SIA: Ø Centroid

* Villegas EL, Alcón E, Artal P. Minimum amount of astigmatism that should be corrected. J Cataract Refract Surg 2014; 40: n My SIA: Ø Centroid Astigmatism correction in cataract surgery: A work in progress 9 things you should know Douglas D. Koch, M.D. Cullen Eye Institute Baylor College of Medicine Houston, Texas Financial disclosure: AMO Alc

More information

POST-OPERATIVE ASTIGMATISM AFTER SICS AND PHACOEMULSIFICATION.

POST-OPERATIVE ASTIGMATISM AFTER SICS AND PHACOEMULSIFICATION. 4 POST-OPERATIVE ASTIGMATISM AFTER SICS AND PHACOEMULSIFICATION. Dr.Vijay Damor, Dr.Anupama Mahant, Department of ophthalmology,amc MET Medical college. Ahmedabad pin 380008 Abstract : Background: Astigmatism

More information

Amblyopia in astigmatic children: Patterns of dewcits

Amblyopia in astigmatic children: Patterns of dewcits Vision Research 47 (2007) 315 326 www.elsevier.com/locate/visres Amblyopia in astigmatic children: Patterns of dewcits Erin M. Harvey a,b,, Velma Dobson a,c, Joseph M. Miller a,b,d, Candice E. CliVord-Donaldson

More information

Orthokeratology (Ortho-K), or corneal refractive therapy, is. Toric Double Tear Reservoir Contact Lens in Orthokeratology for Astigmatism ARTICLE

Orthokeratology (Ortho-K), or corneal refractive therapy, is. Toric Double Tear Reservoir Contact Lens in Orthokeratology for Astigmatism ARTICLE ARTICLE Toric Double Tear Reservoir Contact Lens in Orthokeratology for Astigmatism Jaume Pauné, M.Sc., Genís Cardona, Ph.D., and Lluïsa Quevedo, Ph.D. Objectives: This study aimed at assessing the performance

More information

Postoperative Astigmatic Outcomes Based on the Haptic Axis of Intraocular Lenses Inserted in Cataract Surgery

Postoperative Astigmatic Outcomes Based on the Haptic Axis of Intraocular Lenses Inserted in Cataract Surgery pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2011;25(1):22-28 DOI: 10.3341/kjo.2011.25.1.22 Original Article Postoperative Astigmatic Outcomes Based on the Haptic Axis of Intraocular Lenses Inserted

More information

OPTOMETRY INVITED REVIEW. A review of astigmatism and its possible genesis

OPTOMETRY INVITED REVIEW. A review of astigmatism and its possible genesis C L I N I C A L A N D E X P E R I M E N T A L OPTOMETRY INVITED REVIEW A review of astigmatism and its possible genesis Clin Exp Optom 2007; 90: 1: 5 19 Scott A Read PhD Michael J Collins PhD Leo G Carney

More information

Analysis of WFS Measurements from first half of 2004

Analysis of WFS Measurements from first half of 2004 Analysis of WFS Measurements from first half of 24 (Report4) Graham Cox August 19, 24 1 Abstract Described in this report is the results of wavefront sensor measurements taken during the first seven months

More information

AstigmatismamongotherRefractiveErrorsinChildrenofSouthernSriLanka. Astigmatism among other Refractive Errors in Children of Southern Sri Lanka

AstigmatismamongotherRefractiveErrorsinChildrenofSouthernSriLanka. Astigmatism among other Refractive Errors in Children of Southern Sri Lanka : F Diseases Volume 15 Issue 1 Version 1.0 Year 2015 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA) Online ISSN: 2249-4618 & Print ISSN: 0975-5888

More information

DELTA MODULATION AND DPCM CODING OF COLOR SIGNALS

DELTA MODULATION AND DPCM CODING OF COLOR SIGNALS DELTA MODULATION AND DPCM CODING OF COLOR SIGNALS Item Type text; Proceedings Authors Habibi, A. Publisher International Foundation for Telemetering Journal International Telemetering Conference Proceedings

More information

Treatment of astigmatism-related amblyopia in 3- to 5-year-old children

Treatment of astigmatism-related amblyopia in 3- to 5-year-old children Vision Research 44 (2004) 1623 1634 www.elsevier.com/locate/visres Treatment of astigmatism-related amblyopia in 3- to 5-year-old children Erin M. Harvey a, *, Velma Dobson a,b, Joseph M. Miller a,c,d,

More information

AP Statistics Sampling. Sampling Exercise (adapted from a document from the NCSSM Leadership Institute, July 2000).

AP Statistics Sampling. Sampling Exercise (adapted from a document from the NCSSM Leadership Institute, July 2000). AP Statistics Sampling Name Sampling Exercise (adapted from a document from the NCSSM Leadership Institute, July 2000). Problem: A farmer has just cleared a field for corn that can be divided into 100

More information

A novel method for human Astigmatism formulation and measurement

A novel method for human Astigmatism formulation and measurement Available online at http://www.ijabbr.com International journal of Advanced Biological and Biomedical Research Volume 1, Issue 8, 2013: 874-884 A novel method for human Astigmatism formulation and measurement

More information

Draft 100G SR4 TxVEC - TDP Update. John Petrilla: Avago Technologies February 2014

Draft 100G SR4 TxVEC - TDP Update. John Petrilla: Avago Technologies February 2014 Draft 100G SR4 TxVEC - TDP Update John Petrilla: Avago Technologies February 2014 Supporters David Cunningham Jonathan King Patrick Decker Avago Technologies Finisar Oracle MMF ad hoc February 2014 Avago

More information

Chapter 27. Inferences for Regression. Remembering Regression. An Example: Body Fat and Waist Size. Remembering Regression (cont.)

Chapter 27. Inferences for Regression. Remembering Regression. An Example: Body Fat and Waist Size. Remembering Regression (cont.) Chapter 27 Inferences for Regression Copyright 2007 Pearson Education, Inc. Publishing as Pearson Addison-Wesley Slide 27-1 Copyright 2007 Pearson Education, Inc. Publishing as Pearson Addison-Wesley An

More information

Estimation of inter-rater reliability

Estimation of inter-rater reliability Estimation of inter-rater reliability January 2013 Note: This report is best printed in colour so that the graphs are clear. Vikas Dhawan & Tom Bramley ARD Research Division Cambridge Assessment Ofqual/13/5260

More information

Do the near computerised and non-computerised crowded Kay picture tests produce the same measure of visual acuity?

Do the near computerised and non-computerised crowded Kay picture tests produce the same measure of visual acuity? : 22 28 Do the near computerised and non-computerised crowded Kay picture tests produce the same measure of visual acuity? AARON J. DAWKINS MMedSci BMedSci (Hons) AND ANNE BJERRE MSc BSc (Hons) Department

More information

The Measurement Tools and What They Do

The Measurement Tools and What They Do 2 The Measurement Tools The Measurement Tools and What They Do JITTERWIZARD The JitterWizard is a unique capability of the JitterPro package that performs the requisite scope setup chores while simplifying

More information

UNIVERSAL SPATIAL UP-SCALER WITH NONLINEAR EDGE ENHANCEMENT

UNIVERSAL SPATIAL UP-SCALER WITH NONLINEAR EDGE ENHANCEMENT UNIVERSAL SPATIAL UP-SCALER WITH NONLINEAR EDGE ENHANCEMENT Stefan Schiemenz, Christian Hentschel Brandenburg University of Technology, Cottbus, Germany ABSTRACT Spatial image resizing is an important

More information

NAA ENHANCING THE QUALITY OF MARKING PROJECT: THE EFFECT OF SAMPLE SIZE ON INCREASED PRECISION IN DETECTING ERRANT MARKING

NAA ENHANCING THE QUALITY OF MARKING PROJECT: THE EFFECT OF SAMPLE SIZE ON INCREASED PRECISION IN DETECTING ERRANT MARKING NAA ENHANCING THE QUALITY OF MARKING PROJECT: THE EFFECT OF SAMPLE SIZE ON INCREASED PRECISION IN DETECTING ERRANT MARKING Mudhaffar Al-Bayatti and Ben Jones February 00 This report was commissioned by

More information

Astigmatism in infant monkeys reared with cylindrical lenses

Astigmatism in infant monkeys reared with cylindrical lenses Vision Research 43 (2003) 2721 2739 www.elsevier.com/locate/visres Astigmatism in infant monkeys reared with cylindrical lenses Chea-su Kee, Li-Fang Hung, Ying Qiao, Earl L. Smith III * College of Optometry,

More information

The Research of Controlling Loudness in the Timbre Subjective Perception Experiment of Sheng

The Research of Controlling Loudness in the Timbre Subjective Perception Experiment of Sheng The Research of Controlling Loudness in the Timbre Subjective Perception Experiment of Sheng S. Zhu, P. Ji, W. Kuang and J. Yang Institute of Acoustics, CAS, O.21, Bei-Si-huan-Xi Road, 100190 Beijing,

More information

N12/5/MATSD/SP2/ENG/TZ0/XX. mathematical STUDIES. Wednesday 7 November 2012 (morning) 1 hour 30 minutes. instructions to candidates

N12/5/MATSD/SP2/ENG/TZ0/XX. mathematical STUDIES. Wednesday 7 November 2012 (morning) 1 hour 30 minutes. instructions to candidates 88127402 mathematical STUDIES STANDARD level Paper 2 Wednesday 7 November 2012 (morning) 1 hour 30 minutes instructions to candidates Do not open this examination paper until instructed to do so. A graphic

More information

Linear mixed models and when implied assumptions not appropriate

Linear mixed models and when implied assumptions not appropriate Mixed Models Lecture Notes By Dr. Hanford page 94 Generalized Linear Mixed Models (GLMM) GLMMs are based on GLM, extended to include random effects, random coefficients and covariance patterns. GLMMs are

More information

OPTOMETRY. An analysis of the astigmatic changes induced by accelerated o rt ho ke ratolog y I ORIGINALPAPER 1

OPTOMETRY. An analysis of the astigmatic changes induced by accelerated o rt ho ke ratolog y I ORIGINALPAPER 1 OPTOMETRY I ORIGINALPAPER 1 An analysis of the astigmatic changes induced by accelerated o rt ho ke ratolog y Clin Exp Optom ; 85: 5: 84-93 John Mountford* DipAppSc FAAO FVCO FCLS Konrad Pesudovst PhD

More information

STAT 113: Statistics and Society Ellen Gundlach, Purdue University. (Chapters refer to Moore and Notz, Statistics: Concepts and Controversies, 8e)

STAT 113: Statistics and Society Ellen Gundlach, Purdue University. (Chapters refer to Moore and Notz, Statistics: Concepts and Controversies, 8e) STAT 113: Statistics and Society Ellen Gundlach, Purdue University (Chapters refer to Moore and Notz, Statistics: Concepts and Controversies, 8e) Learning Objectives for Exam 1: Unit 1, Part 1: Population

More information

Bootstrap Methods in Regression Questions Have you had a chance to try any of this? Any of the review questions?

Bootstrap Methods in Regression Questions Have you had a chance to try any of this? Any of the review questions? ICPSR Blalock Lectures, 2003 Bootstrap Resampling Robert Stine Lecture 3 Bootstrap Methods in Regression Questions Have you had a chance to try any of this? Any of the review questions? Getting class notes

More information

Measurement of overtone frequencies of a toy piano and perception of its pitch

Measurement of overtone frequencies of a toy piano and perception of its pitch Measurement of overtone frequencies of a toy piano and perception of its pitch PACS: 43.75.Mn ABSTRACT Akira Nishimura Department of Media and Cultural Studies, Tokyo University of Information Sciences,

More information

SEVENTH GRADE. Revised June Billings Public Schools Correlation and Pacing Guide Math - McDougal Littell Middle School Math 2004

SEVENTH GRADE. Revised June Billings Public Schools Correlation and Pacing Guide Math - McDougal Littell Middle School Math 2004 SEVENTH GRADE June 2010 Billings Public Schools Correlation and Guide Math - McDougal Littell Middle School Math 2004 (Chapter Order: 1, 6, 2, 4, 5, 13, 3, 7, 8, 9, 10, 11, 12 Chapter 1 Number Sense, Patterns,

More information

Analysis of local and global timing and pitch change in ordinary

Analysis of local and global timing and pitch change in ordinary Alma Mater Studiorum University of Bologna, August -6 6 Analysis of local and global timing and pitch change in ordinary melodies Roger Watt Dept. of Psychology, University of Stirling, Scotland r.j.watt@stirling.ac.uk

More information

Blueline, Linefree, Accuracy Ratio, & Moving Absolute Mean Ratio Charts

Blueline, Linefree, Accuracy Ratio, & Moving Absolute Mean Ratio Charts INTRODUCTION This instruction manual describes for users of the Excel Standard Celeration Template(s) the features of each page or worksheet in the template, allowing the user to set up and generate charts

More information

Salt on Baxter on Cutting

Salt on Baxter on Cutting Salt on Baxter on Cutting There is a simpler way of looking at the results given by Cutting, DeLong and Nothelfer (CDN) in Attention and the Evolution of Hollywood Film. It leads to almost the same conclusion

More information

Richard N. McNeely 1,2, Salissou Moutari 3, Eric Pazo 1,2 and Jonathan E. Moore 1,2*

Richard N. McNeely 1,2, Salissou Moutari 3, Eric Pazo 1,2 and Jonathan E. Moore 1,2* McNeely et al. Eye and Vision (2018) 5:7 https://doi.org/10.1186/s40662-018-0103-4 RESEARCH Investigating the impact of preoperative corneal astigmatism orientation on the postoperative spherical equivalent

More information

Relationships Between Quantitative Variables

Relationships Between Quantitative Variables Chapter 5 Relationships Between Quantitative Variables Three Tools we will use Scatterplot, a two-dimensional graph of data values Correlation, a statistic that measures the strength and direction of a

More information

More About Regression

More About Regression Regression Line for the Sample Chapter 14 More About Regression is spoken as y-hat, and it is also referred to either as predicted y or estimated y. b 0 is the intercept of the straight line. The intercept

More information

Astigmatism is a very common refractive error in which the

Astigmatism is a very common refractive error in which the A R T I C L E S Astigmatism Associated with Experimentally Induced Myopia or Hyperopia in Chickens Chea-su Kee 1,2 and Li Deng 1 PURPOSE. Astigmatism is a very common refractive error in humans, but its

More information

Moving on from MSTAT. March The University of Reading Statistical Services Centre Biometrics Advisory and Support Service to DFID

Moving on from MSTAT. March The University of Reading Statistical Services Centre Biometrics Advisory and Support Service to DFID Moving on from MSTAT March 2000 The University of Reading Statistical Services Centre Biometrics Advisory and Support Service to DFID Contents 1. Introduction 3 2. Moving from MSTAT to Genstat 4 2.1 Analysis

More information

Chapter 5. Describing Distributions Numerically. Finding the Center: The Median. Spread: Home on the Range. Finding the Center: The Median (cont.

Chapter 5. Describing Distributions Numerically. Finding the Center: The Median. Spread: Home on the Range. Finding the Center: The Median (cont. Chapter 5 Describing Distributions Numerically Copyright 2007 Pearson Education, Inc. Publishing as Pearson Addison-Wesley Copyright 2007 Pearson Education, Inc. Publishing as Pearson Addison-Wesley Slide

More information

Modeling memory for melodies

Modeling memory for melodies Modeling memory for melodies Daniel Müllensiefen 1 and Christian Hennig 2 1 Musikwissenschaftliches Institut, Universität Hamburg, 20354 Hamburg, Germany 2 Department of Statistical Science, University

More information

ANALYSING DIFFERENCES BETWEEN THE INPUT IMPEDANCES OF FIVE CLARINETS OF DIFFERENT MAKES

ANALYSING DIFFERENCES BETWEEN THE INPUT IMPEDANCES OF FIVE CLARINETS OF DIFFERENT MAKES ANALYSING DIFFERENCES BETWEEN THE INPUT IMPEDANCES OF FIVE CLARINETS OF DIFFERENT MAKES P Kowal Acoustics Research Group, Open University D Sharp Acoustics Research Group, Open University S Taherzadeh

More information

Subtitle Safe Crop Area SCA

Subtitle Safe Crop Area SCA Subtitle Safe Crop Area SCA BBC, 9 th June 2016 Introduction This document describes a proposal for a Safe Crop Area parameter attribute for inclusion within TTML documents to provide additional information

More information

Laboratory Assignment 3. Digital Music Synthesis: Beethoven s Fifth Symphony Using MATLAB

Laboratory Assignment 3. Digital Music Synthesis: Beethoven s Fifth Symphony Using MATLAB Laboratory Assignment 3 Digital Music Synthesis: Beethoven s Fifth Symphony Using MATLAB PURPOSE In this laboratory assignment, you will use MATLAB to synthesize the audio tones that make up a well-known

More information

Relationships. Between Quantitative Variables. Chapter 5. Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc.

Relationships. Between Quantitative Variables. Chapter 5. Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc. Relationships Chapter 5 Between Quantitative Variables Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc. Three Tools we will use Scatterplot, a two-dimensional graph of data values Correlation,

More information

abc Mark Scheme Statistics 3311 General Certificate of Secondary Education Higher Tier 2007 examination - June series

abc Mark Scheme Statistics 3311 General Certificate of Secondary Education Higher Tier 2007 examination - June series abc General Certificate of Secondary Education Statistics 3311 Higher Tier Mark Scheme 2007 examination - June series Mark schemes are prepared by the Principal Examiner and considered, together with the

More information

Astigmatism: analysis and synthesis of the astigmatic ametropia

Astigmatism: analysis and synthesis of the astigmatic ametropia http://eoftalmo.org.br OPINION OF SPECIALISTS Astigmatism: analysis and synthesis of the astigmatic ametropia Astigmatismo: análise e síntese da ametropia astigmática Analysis and synthesis of the astigmatic

More information

JOURNAL OF PHARMACEUTICAL RESEARCH AND EDUCATION AUTHOR GUIDELINES

JOURNAL OF PHARMACEUTICAL RESEARCH AND EDUCATION AUTHOR GUIDELINES SURESH GYAN VIHAR UNIVERSITY JOURNAL OF PHARMACEUTICAL RESEARCH AND EDUCATION Instructions to Authors: AUTHOR GUIDELINES The JPRE is an international multidisciplinary Monthly Journal, which publishes

More information

Irregular Corneal Astigmatism & Cataract

Irregular Corneal Astigmatism & Cataract Costas Karabatsas MD, PhD, MRCOphth, FEBOphth, FRCS Ophth Irregular Corneal Astigmatism & Cataract (assessing ocular surface, IOL selection) In both LRS and Cataract Surgery aim = Emmetropia Refractive

More information

UC San Diego UC San Diego Previously Published Works

UC San Diego UC San Diego Previously Published Works UC San Diego UC San Diego Previously Published Works Title Classification of MPEG-2 Transport Stream Packet Loss Visibility Permalink https://escholarship.org/uc/item/9wk791h Authors Shin, J Cosman, P

More information

FEATURE ARTICLE - PUBLIC ACCESS. Reading Fluency in School-Aged Children with Bilateral Astigmatism

FEATURE ARTICLE - PUBLIC ACCESS. Reading Fluency in School-Aged Children with Bilateral Astigmatism 1040-5488/16/9302-0118/0 VOL. 93, NO. 2, PP. 118Y125 OPTOMETRY AND VISION SCIENCE Copyright * 2016 American Academy of Optometry FEATURE ARTICLE - PUBLIC ACCESS Reading Fluency in School-Aged Children

More information

Analysis of data from the pilot exercise to develop bibliometric indicators for the REF

Analysis of data from the pilot exercise to develop bibliometric indicators for the REF February 2011/03 Issues paper This report is for information This analysis aimed to evaluate what the effect would be of using citation scores in the Research Excellence Framework (REF) for staff with

More information

Douglas Katsev MD Sansum Clinic Chairman Ophthalmology Santa Barbara CA

Douglas Katsev MD Sansum Clinic Chairman Ophthalmology Santa Barbara CA Early Outcomes (9 months) with a Toric Accommodating IOL How do They Fit in My refractive Practice Douglas Katsev MD Sansum Clinic i Chairman Ophthalmology Santa Barbara CA 1 Disclosure Consulting Fee:

More information

hprints , version 1-1 Oct 2008

hprints , version 1-1 Oct 2008 Author manuscript, published in "Scientometrics 74, 3 (2008) 439-451" 1 On the ratio of citable versus non-citable items in economics journals Tove Faber Frandsen 1 tff@db.dk Royal School of Library and

More information

A R Sebai Sarhan, Harminder S Dua, Michelle Beach

A R Sebai Sarhan, Harminder S Dua, Michelle Beach Br J Ophthalmol 2000;84:837 841 837 Division of Ophthalmology and Visual Sciences, University of Nottingham, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH A R S Sarhan H S Dua M Beach

More information

CHAPTER 4 OSCILLOSCOPES

CHAPTER 4 OSCILLOSCOPES CHAPTER 4 OSCILLOSCOPES 4.1 Introduction The cathode ray oscilloscope generally referred to as the oscilloscope, is probably the most versatile electrical measuring instrument available. Some of electrical

More information

AskDrCallahan Calculus 1 Teacher s Guide

AskDrCallahan Calculus 1 Teacher s Guide AskDrCallahan Calculus 1 Teacher s Guide 3rd Edition rev 080108 Dale Callahan, Ph.D., P.E. Lea Callahan, MSEE, P.E. Copyright 2008, AskDrCallahan, LLC v3-r080108 www.askdrcallahan.com 2 Welcome to AskDrCallahan

More information

Resampling Statistics. Conventional Statistics. Resampling Statistics

Resampling Statistics. Conventional Statistics. Resampling Statistics Resampling Statistics Introduction to Resampling Probability Modeling Resample add-in Bootstrapping values, vectors, matrices R boot package Conclusions Conventional Statistics Assumptions of conventional

More information

Mixed Models Lecture Notes By Dr. Hanford page 151 More Statistics& SAS Tutorial at Type 3 Tests of Fixed Effects

Mixed Models Lecture Notes By Dr. Hanford page 151 More Statistics& SAS Tutorial at  Type 3 Tests of Fixed Effects Assessing fixed effects Mixed Models Lecture Notes By Dr. Hanford page 151 In our example so far, we have been concentrating on determining the covariance pattern. Now we ll look at the treatment effects

More information

Refractive, anterior corneal and internal astigmatism in the pseudophakic eye

Refractive, anterior corneal and internal astigmatism in the pseudophakic eye Refractive, anterior corneal and internal astigmatism in the pseudophakic eye Jesper F. Bregnhøj, 1,2 Pourang Mataji 1,2 and Kristian Næser 1,2 1 Department of Ophthalmology, Aarhus University Hospital,

More information

Reconstruction of Ca 2+ dynamics from low frame rate Ca 2+ imaging data CS229 final project. Submitted by: Limor Bursztyn

Reconstruction of Ca 2+ dynamics from low frame rate Ca 2+ imaging data CS229 final project. Submitted by: Limor Bursztyn Reconstruction of Ca 2+ dynamics from low frame rate Ca 2+ imaging data CS229 final project. Submitted by: Limor Bursztyn Introduction Active neurons communicate by action potential firing (spikes), accompanied

More information

Estimating. Proportions with Confidence. Chapter 10. Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc.

Estimating. Proportions with Confidence. Chapter 10. Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc. Estimating Chapter 10 Proportions with Confidence Copyright 2006 Brooks/Cole, a division of Thomson Learning, Inc. Principal Idea: Survey 150 randomly selected students and 41% think marijuana should be

More information

Technical Appendices to: Is Having More Channels Really Better? A Model of Competition Among Commercial Television Broadcasters

Technical Appendices to: Is Having More Channels Really Better? A Model of Competition Among Commercial Television Broadcasters Technical Appendices to: Is Having More Channels Really Better? A Model of Competition Among Commercial Television Broadcasters 1 Advertising Rates for Syndicated Programs In this appendix we provide results

More information

Overview. Teacher s Manual and reproductions of student worksheets to support the following lesson objective:

Overview. Teacher s Manual and reproductions of student worksheets to support the following lesson objective: Overview Lesson Plan #1 Title: Ace it! Lesson Nine Attached Supporting Documents for Plan #1: Teacher s Manual and reproductions of student worksheets to support the following lesson objective: Find products

More information

1996 Yampi Shelf, Browse Basin Airborne Laser Fluorosensor Survey Interpretation Report [WGC Browse Survey Number ]

1996 Yampi Shelf, Browse Basin Airborne Laser Fluorosensor Survey Interpretation Report [WGC Browse Survey Number ] 1996 Yampi Shelf, Browse Basin Airborne Laser Fluorosensor Survey Interpretation Report [WGC Browse Survey Number 1248.1] Prepared For Australian Geological Survey Organisation April 2000 AGSO Record No.

More information

Detecting Medicaid Data Anomalies Using Data Mining Techniques Shenjun Zhu, Qiling Shi, Aran Canes, AdvanceMed Corporation, Nashville, TN

Detecting Medicaid Data Anomalies Using Data Mining Techniques Shenjun Zhu, Qiling Shi, Aran Canes, AdvanceMed Corporation, Nashville, TN Paper SDA-04 Detecting Medicaid Data Anomalies Using Data Mining Techniques Shenjun Zhu, Qiling Shi, Aran Canes, AdvanceMed Corporation, Nashville, TN ABSTRACT The purpose of this study is to use statistical

More information

Open Access Determinants and the Effect on Article Performance

Open Access Determinants and the Effect on Article Performance International Journal of Business and Economics Research 2017; 6(6): 145-152 http://www.sciencepublishinggroup.com/j/ijber doi: 10.11648/j.ijber.20170606.11 ISSN: 2328-7543 (Print); ISSN: 2328-756X (Online)

More information

Brief Report. Development of a Measure of Humour Appreciation. Maria P. Y. Chik 1 Department of Education Studies Hong Kong Baptist University

Brief Report. Development of a Measure of Humour Appreciation. Maria P. Y. Chik 1 Department of Education Studies Hong Kong Baptist University DEVELOPMENT OF A MEASURE OF HUMOUR APPRECIATION CHIK ET AL 26 Australian Journal of Educational & Developmental Psychology Vol. 5, 2005, pp 26-31 Brief Report Development of a Measure of Humour Appreciation

More information

Example the number 21 has the following pairs of squares and numbers that produce this sum.

Example the number 21 has the following pairs of squares and numbers that produce this sum. by Philip G Jackson info@simplicityinstinct.com P O Box 10240, Dominion Road, Mt Eden 1446, Auckland, New Zealand Abstract Four simple attributes of Prime Numbers are shown, including one that although

More information

For the SIA. Applications of Propagation Delay & Skew tool. Introduction. Theory of Operation. Propagation Delay & Skew Tool

For the SIA. Applications of Propagation Delay & Skew tool. Introduction. Theory of Operation. Propagation Delay & Skew Tool For the SIA Applications of Propagation Delay & Skew tool Determine signal propagation delay time Detect skewing between channels on rising or falling edges Create histograms of different edge relationships

More information

Visual Encoding Design

Visual Encoding Design CSE 442 - Data Visualization Visual Encoding Design Jeffrey Heer University of Washington A Design Space of Visual Encodings Mapping Data to Visual Variables Assign data fields (e.g., with N, O, Q types)

More information

White Paper. Astigmatism Management With Toric IOLs The Importance of Rotational Stability After IOL Implantation. Xiaolin Gu, M.D., PhD.

White Paper. Astigmatism Management With Toric IOLs The Importance of Rotational Stability After IOL Implantation. Xiaolin Gu, M.D., PhD. White Paper Astigmatism Management With Toric IOLs The Importance of Rotational Stability After IOL Implantation Xiaolin Gu, M.D., PhD. Introduction Cataracts, or clouding of the crystalline lens, are

More information

COMP Test on Psychology 320 Check on Mastery of Prerequisites

COMP Test on Psychology 320 Check on Mastery of Prerequisites COMP Test on Psychology 320 Check on Mastery of Prerequisites This test is designed to provide you and your instructor with information on your mastery of the basic content of Psychology 320. The results

More information

Handout Course Title : Astigmatisme Management with toric IOL

Handout Course Title : Astigmatisme Management with toric IOL Handout Course Title : Astigmatisme Management with toric IOL ESCRS Milano 2012 Level :Basic Course leader : Jerome jean Bovet Course duration : 2 hours Faculty : Jerome Bovet, Warren Hill Keiki Mehta

More information

Does the number of users rating the movie accurately predict the average user rating?

Does the number of users rating the movie accurately predict the average user rating? STAT 503 Assignment 1: Movie Ratings SOLUTION NOTES These are my suggestions on how to analyze this data and organize the results. I ve given more questions below than I can address in my analysis, so

More information

Subjective evaluation of common singing skills using the rank ordering method

Subjective evaluation of common singing skills using the rank ordering method lma Mater Studiorum University of ologna, ugust 22-26 2006 Subjective evaluation of common singing skills using the rank ordering method Tomoyasu Nakano Graduate School of Library, Information and Media

More information

New method of quantifying corneal topographic astigmatism that corresponds with manifest refractive cylinder

New method of quantifying corneal topographic astigmatism that corresponds with manifest refractive cylinder ARTICLE New method of quantifying corneal topographic astigmatism that corresponds with manifest refractive cylinder Noel Alpins, FRANZCO, FRCOphth, FACS, James K.Y. Ong, BOptom, Dr.rer.nat, George Stamatelatos,

More information

Restoration of Hyperspectral Push-Broom Scanner Data

Restoration of Hyperspectral Push-Broom Scanner Data Restoration of Hyperspectral Push-Broom Scanner Data Rasmus Larsen, Allan Aasbjerg Nielsen & Knut Conradsen Department of Mathematical Modelling, Technical University of Denmark ABSTRACT: Several effects

More information

Machine Learning Term Project Write-up Creating Models of Performers of Chopin Mazurkas

Machine Learning Term Project Write-up Creating Models of Performers of Chopin Mazurkas Machine Learning Term Project Write-up Creating Models of Performers of Chopin Mazurkas Marcello Herreshoff In collaboration with Craig Sapp (craig@ccrma.stanford.edu) 1 Motivation We want to generative

More information